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J Nucl Med Technol ; 51(3): 215-219, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37163648

RESUMO

The protein expression of the prostate-specific membrane antigen correlates with unfavorable or aggressive histologic features of prostate cancer, resulting in use as a diagnostic PET imaging radiotracer and therapeutic target. Here, we discuss the methods to develop 225Ac-DOTA-J591, an α-labeled compound targeting an extracellular epitope of prostate-specific membrane antigen, which is currently being studied in early clinical trials. In addition, we review quality control, radiation safety measures, and clinical considerations before administration of this radioimmunotherapeutic agent.


Assuntos
Próstata , Neoplasias da Próstata , Masculino , Humanos , Estados Unidos , Neoplasias da Próstata/patologia , Tomografia por Emissão de Pósitrons , Universidades , Compostos Radiofarmacêuticos
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