Visible-light-induced cascade reaction: a sustainable approach towards molecular complexity.

Photoredox catalysis has demonstrated rapid evolution in the field of synthetic organic chemistry. On the other hand, the splendour of cascade reactions in providing complex molecular architectures renders them a cutting-edge research area. Therefore, the merging of photocatalysis with cascade synthesis brings out a synthetic paradigm with immense potential. The development of photocascade catalysis for a target molecule with a particular molecular skeleton and stereochemical framework presents certain challenges but provides a robust and environmentally benign synthetic alternative. This comprehensive review assembles all the accomplishments and highlights of visible-light-induced cascade reactions with literature coverage up to October 2022.

Ortho C-H Functionalizations of 2-Aryl-2H-Indazoles.

C-H Functionalization is ubiquitously considered as a powerful, efficient and handy tool for installing various functional groups in complex organic heterocycles in an easier and step-economic way. Similarly, indazole is endowed as a potent heterocycle and is eminent for its profound impact in biological, medicinal and industrial chemistry. In this scenario, C-H functionalization at the selective ortho position of 2-arylindazole in assistance of a metal catalyst is also becoming an appealing approach in synthetic organic chemistry. This review addressed the recent findings and developments on ortho C-H functionalization of 2-aryl-2H-indazazoles with literature coverage extending from 2018 to May 2022.

Asymmetric C(sp3)-H borylation: an update.

Chiral organoboronates have emerged as a key intermediate in the development of pharmaceuticals and materials science. Therefore, several attempts have been made to design various synthetic methods to easily furnish these compounds during the past few decades. Inter alia, asymmetric catalysis has been increasing rapidly as a viable, practical and beneficial strategy for their preparation. In this respect, recent years have witnessed significant progress in aliphatic C-H borylation as the generated carbon-boron bonds are largely utilized to produce other carbon-carbon, carbon-nitrogen and carbon-oxygen bonds. This review presents a detailed overview and analysis of transition metal-catalyzed asymmetric C(sp3)-H borylation strategies. Overall, it assembles all the recent developments in this particular synthetic avenue up to March 2022.

Visible light-induced functionalization of indazole and pyrazole: a recent update.

Indazole and pyrazole are renowned as a prodigious class of heterocycles having versatile uses in medicinal as well as industrial chemistry. Considering sustainable approaches, recently, photocatalysis has become an indispensable tool in organic chemistry due to its application for the activation of small molecules and the use of a clean energy source. In this review, we have highlighted the use of metal-based photocatalysts, organic photoredox catalysts, energy transfer photocatalysts and electron-donor-acceptor complexes in the functionalization of indazole and pyrazole. This perspective is arranged based on the types of functionalization reactions on indazole and pyrazole. A detailed discussion regarding the reaction mechanism of each reaction is given to provide a comprehensive guide to the reader. Finally, a summary of existing challenges and the future outlook towards the development of efficient photocatalytic methods for functionalization of these heterocycles is also presented.

Synthesis of Unsymmetrical Biheteroarenes via Dehydrogenative and Decarboxylative Coupling: a Decade Update.

The design and development of robust and efficient methods for installing one heterocycle with another is endowed as a ubiquitous and powerful synthetic strategy to access complex organic biheterocycles in recent days due to their pervasive applications in medicinal as well as material chemistry. This perspective presents an overview on the recent findings and developments for the synthesis of unsymmetrical biheteroarenes via dehydrogenative and decarboxylative couplings with literature coverage mainly extending from 2011 to 2021. For simplification of the readers, the article has been subcategorized based on the catalysts used in the reactions.