Adverse Events of Mind-Body Interventions in Children: A Systematic Review.

Mind-body interventions (MBIs) are one of the top ten complementary approaches utilized in pediatrics, but there is limited knowledge on associated adverse events (AE). The objective of this review was to systematically review AEs reported in association with MBIs in children. In this systematic review the electronic databases MEDLINE, Embase, CINAHL, CDSR, and CCRCT were searched from inception to August 2018. We included primary studies on participants ≤ 21 years of age that used an MBI. Experimental studies were assessed for whether AEs were reported on or not, and all other study designs were included only if they reported an AE. A total of 441 were included as primary pediatric MBI studies. Of these, 377 (85.5%) did not explicitly report the presence/absence of AEs or a safety assessment. There were 64 included studies: 43 experimental studies reported that no AE occurred, and 21 studies reported AEs. There were 37 AEs found, of which the most serious were grade 3. Most of the studies reporting AEs did not report on severity (81.0%) or duration of AEs (52.4%). MBIs are popularly used in children; however associated harms are often not reported and lack important information for meaningful assessment.

Forty-eight years of research on psychosocial interventions in the treatment of opioid use disorder: A scoping review.

BACKGROUND: Mapped the sources and types of evidence available on psychosocial interventions in the treatment of opioid use disorder (OUD), with and without pharmacotherapies. METHODS: Six electronic databases were searched for research published until July 1, 2019. Included studies were coded on publication characteristics, evidence sources, treatment settings and modalities, study populations and patient characteristics, intervention(s) offered to patients, research questions addressed in experimental studies, and outcomes investigated. RESULTS: We identified 305 empirical studies of 54,607 patients. Most studies (64 %; n = 194) compared psychosocial interventions to alternative treatment(s) (183 RCTs and 11 quasi-experiments) while 28 % (n = 86) used observational designs, and 8% (n = 25) used qualitative methods. Trials infrequently investigated effects of stand-alone psychosocial interventions without pharmacotherapies (20% of all RCTs). Regardless of research question or study design, program retention and illicit drug use were the most common outcomes investigated (> 81% of all studies and RCTs), typically among longstanding male heroin users attending specialty outpatient addiction services. Studies rarely examined (a) OUD treatment in general health care or prescription OUD (each < 6 % of all studies and RCTs), (b) effects of social assistance (employment, education, social support) and harm reduction (each < 6 % of studies; < 7 % of RCTs), and (c) health-related quality of life and satisfaction with care (each < 10 % and < 15 % of all studies and RCTs, respectively). CONCLUSIONS: Scant evidence is available on the putative rehabilitative effects of psychosocial interventions, either as stand-alone treatments or in an adjunct role to pharmacotherapies.

Fruit, vegetables, and the prevention of cancer: research challenges.

OBJECTIVE: A great deal of epidemiologic evidence has indicated that fruits and vegetables are protective against numerous forms of cancer. However, there are many gaps in our knowledge. METHODS: In this pilot study we reviewed more than 200 cohort and case-control studies to determine the shape of the dose-response relationship (i.e., how the risk reduction per extra serving of fruits and vegetables changes with the actual intake of these foods). We found major barriers to investigating this. As part of this pilot study we also investigated whether specific fruits and vegetables are responsible for the anticancer action of these foods or whether a wide variety is required for optimal protection. If the former is correct, then fruits and vegetables may contain one or a small number of "magic bullets"; if the latter is correct, then a "teamwork" concept may be valid. RESULTS: Different findings suggested that the teamwork concept is much more likely. Many studies, especially older ones, have ignored potential confounding variables such as energy intake, alcohol consumption, physical activity, body mass index, smoking, and socioeconomic status (although many recent studies have adjusted for education). Other potential confounders that have generally been ignored are consumption of whole grain cereals and the use of vitamin and mineral supplements. CONCLUSIONS: The inverse association between intake of fruits and vegetables and the risk of cancer of the colon, breast, and stomach has generally been much stronger in case-control than in cohort studies. We have no clear explanation for this.