1.
Eur Neuropsychopharmacol
; 4(4): 487-90, 1994 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7894259
RESUMO
Inositol is a key metabolite in the phosphatidylinositol cycle, which is a second messenger system for serotonin-2 receptors that have been implicated in the pathophysiology of schizophrenia. Cerebrospinal fluid inositol levels were measured in 20 schizophrenic patients and 19 age- and sex-matched controls and no difference was found. However, the patients were all neuroleptic-treated. A controlled double-blind crossover trial of 12 g daily of inositol for a month in 12 anergic schizophrenic patients, twice the dose given before in schizophrenia, did not show any beneficial effects. However, the number of patients studied was small and the length of time of inositol administration may not have been sufficient.
Assuntos
Inositol/líquido cefalorraquidiano , Inositol/uso terapêutico , Esquizofrenia/líquido cefalorraquidiano , Esquizofrenia/tratamento farmacológico , Adulto , Feminino , Humanos , Inositol/administração & dosagem , Masculino , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica
2.
Harefuah
; 121(7-8): 240-4, 1991 Oct.
Artigo
em Hebraico
| MEDLINE
| ID: mdl-1783314