[Spontaneous coronavirus infection in monkeys]. / Spontannaia koronavirusnaia infektsiia obez'ian.

A high level of the spread of coronavirus (CV) infection among hamadryas baboons and macaques of different species (about 50%), both resident in the animal house and imported, has been established. The tropism of CV to the gastrointestinal and respiratory tracts has been demonstrated. The course of spontaneous CV infection is accompanied by enterocolitis and/or pneumonia with periodic exacerbations, or takes the inapparent form. Cases of virus persistence have also been noted. Infected macaques exhibited an increase in the titers of antibodies to their own CV strain isolated from these animals, as well as to antigenically related human CV strain 0043. Spontaneous CV infection in monkeys may be used for solving some obscure problems of the pathogenesis and epidemiology of CV infection in humans.

[The experimental coronavirus infection of monkeys]. / Eksperimental'naia koronavirusnaia infektsiia obez'ian.

The coronavirus (CV) infection has been reproduced on monkeys (Macaca mulatta) for the first time. The strain CVRM 281, obtained from rhesus monkey who died of the spontaneous CV injection, has been used for the infection. The experimental CV infection has a chronic current with periodical relapses and virus persistence. Gastrointestinal tract (enterocolitis) and respiratory tract (pneumonia) are damaged exhibiting characteristic histological lesions. The monkey model of the CV injection can be used to solve obscure questions of human one.

[The properties of simian coronavirus]. / Izuchenie svoistv koronavirusa obez'ian.

Properties of 20 coronavirus (CV) isolates obtained from spontaneously infected Papio hamadryas and rhesus monkeys were investigated. Two of them were selected as simian CV prototype strains-CVRM 281 (rhesus monkey) and CVP 250 (Papio hamadryas), and can be offered as candidates to the Coronaviridae family. They are closely related to each other, but differ in some biological properties and polypeptides. These strains belong to the 2nd antigen group of mammalian CV with the prototype strain HCV OC 43 but differ from the latter. The strain CVRM 281 induces experimental CV infection which can be used as a model for investigations of some obscure aspects of human infection. The properties of these viruses suggest their usefulness for diagnostic purposes.

[Role of soil air in the development of acute pesticide poisoning in agricultural workers]. / O roli pochvennogo vozdukha v vozniknovenii ostrykh otravlenii sel'skokhoziaistvennykh rabochikh pestitsidami.

The mechanism of the high concentrations of pesticides in overground air is described. Equivocation and computer program for the pesticides concentration to calculations are worked out.

[A hygienic basis for dosing the injection of coal flotation wastes into the soil as a fertilizer]. / Gigienicheskoe obosnovanie dozy vneseniia otkhodov flotatsii uglia v pochvu v kachestve udobreniia.

Hygienic regulations for the use of coal flotation wastes (CFW) as fertilizers were substantiated by studying the laws of migration of harmful ingredients of CFW from the fertilized soil to the contacting media. The safe doze of CFW to be used as a fertilizer was determined to be 3 g per 1 kg of soil (10 t/ha).

[Use of the mother-fetus-newborn infant system for the study of combined effects of pesticides and other chemicals]. / Ispol'zovanie sistemy mat'-plod-novorozhdenny'i dlia izucheniia kombinirovannogo deistviia pestitsidov i drugikh khimicheskikh veshchestv.

It is possible to state on the basis of the studies carried out that the system mother-fetus-new-born may be used as the most sensitive biological model to study separate, complex and combined exposure of mammals to chemicals. It was found out that the above mentioned system is highly sensitive and makes it possible to detect a damaging effect to chemicals even on the level of standardized values, while such doses do not produce any negative influence on the adult organism. The proposed system makes it possible to assess material and functional cumulation of chemical substances in the organism of mammals.

[Hygienic significance of soil concerning the health status of the population]. / Gigienicheskoe znachenie pochvy v formirovanii zdorov'ia naseleniia.

On the basis of epidemiological studies and literature data analysis it is possible to state that excessive contamination of soil by exogenous chemicals administered purposefully (pesticides and mineral fertilizers) and as a result, technologic pollution (lead, mercury, arsenic, molybdenum, etc.) causes high content of those contacting with soil: ambient air, water of water sources, cultivated plants. Human intake of significant amounts of exogenous chemicals, contaminating soil, may lead to changes in health status of the population, appearance of acute and chronic poisoning by exogenous chemicals.