RESUMO
BACKGROUND: Cytomegalovirus (CMV) is one of the most common opportunistic infections in AIDS patients. The aim of this study was to assess the influence of CMV infection in the first year of life and its the impact on survival and progression of the disease. MATERIAL/METHODS: This prospective cohort study included all children with a diagnosis of HIV infection in the first year of life followed at the University Hospital 12 de Octubre, Madrid. Urine culture was performed at birth or as soon as the diagnosis of HIV was given. RESULTS: Among the 81 patients studied, 16 presented a positive culture for CMV in urine during the first year of life. At 2 and 5 years of age, 23.6% and 39.6% of the children, respectively, died among those children without CMV infection, whereas 20% and 40% of children with acquired CMV died at this time point. Neither a greater progression of the disease nor any differences in the degree of immunosupression were observed among the children infected with CMV compared with those not infected. CONCLUSIONS: In this study no relationships between CMV infection during the first year of life and faster progression of HIV infection or lower survival or a greater degree of immunosuppression in HIV-infected children was observed.
Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , Síndrome da Imunodeficiência Adquirida/fisiopatologia , Infecções por Citomegalovirus/complicações , Tolerância Imunológica/imunologia , Síndrome da Imunodeficiência Adquirida/tratamento farmacológico , Síndrome da Imunodeficiência Adquirida/imunologia , Síndrome da Imunodeficiência Adquirida/mortalidade , Terapia Antirretroviral de Alta Atividade , Linfócitos T CD4-Positivos/imunologia , Pré-Escolar , Estudos de Coortes , Infecções por Citomegalovirus/urina , Progressão da Doença , Citometria de Fluxo , Humanos , Estudos Prospectivos , EspanhaRESUMO
UNLABELLED: We report the outpatient management of acalculous colecistitis in an 18-y-old male with X-linked chronic granulomatous disease. The patient complained of abdominal pain and the initial ultrasound showed a gallbladder with a thickened wall. CONCLUSION: In chronic granulomatous disease, pain from a thickened gallbladder disappears after oral treatment with glucocorticoids and antibiotics.