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Polycyclic heterocycles are the most common and critical structural motifs found in a variety of natural products, medicines, fertilizers, and advanced materials. Because of their widespread use in biologically active compounds and material chemistry, functionalised dibenzo heterocyclic compounds, especially dibenzofuran, dibenzothiophene, and carbazole derivatives, garnered much attention over time. Scientists are especially interested in elucidating more efficient techniques for developing these industrially essential compounds. Dibenzo-fused heterocycles can rapidly be synthesised using highly efficient transition metal-catalysed strategies as well as by economic metal-free reaction conditions. This review includes a detailed overview of the most recent significant synthetic techniques, both metal-catalysed and metal-free, to produce these industrially significant and medicinally important dibenzo-fused heterocycles.
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Temperature-dependent kinetics of OH radical and Cl atom-initiated reaction of an important halogenated alkene, 2,3-Dichloropropene (23DCP), were investigated using absolute and relative methods over 278-363 K. Pulsed laser photolysis - laser induced fluorescence technique and relative rate method using gas chromatography with flame ionization detector were employed for studying the kinetics of 23DCP with OH radical and Cl atom, respectively. The obtained Arrhenius expressions were kOH(expt)=(4.08 ± 1.63) × 10-13exp{(1043 ± 124)/T} cm3 molecule-1 s-1 and kCl(expt)=(1.54 ± 0.24) × 10-11exp{(705 ± 48)/T} cm3 molecule-1 s-1. Computational calculations were conducted to validate our experimental kinetic results and provide new insights into the importance of a particular pathway among all based on thermodynamic parameters. The addition of OH/Cl to the terminal carbon of the double bond present in 23DCP proved to be the predominant pathway across the selected temperature range for the present study (200-400 K). The degradation mechanism of these reactions was proposed by analyzing the products with the aid of gas chromatography with mass spectrometry. Calculating various atmospheric implication parameters can help to understand how the release of 23DCP may affect the troposphere.
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Compostos Alílicos , Hidrocarbonetos Clorados , Radical Hidroxila , Radical Hidroxila/química , Cinética , Hidrocarbonetos Clorados/química , Compostos Alílicos/química , Atmosfera/química , Termodinâmica , Cloro/química , Temperatura , Poluentes Atmosféricos/química , Fotólise , Propano/análogos & derivadosRESUMO
Background Type 2 diabetes mellitus (T2DM) is one of the most common non-communicable diseases, causing a high mortality rate globally. Vitamin D deficiency has been reported as a rising pandemic. Vitamin D levels have been found to be associated with obesity and insulin resistance. However, there is not much research done to study the various factors associated with the association between vitamin D levels and diabetes mellitus in the Indian population. Objective The objective of this study is to estimate the prevalence of vitamin D deficiency in T2DM patients and find the factors associated with vitamin D levels among type 2 diabetes mellitus patients. Materials and methods A cross-sectional analytical study was planned and done in the Urban Health Training Centre of Dr. D.Y. Patil Medical College. The sample size was calculated using published data on prevalence. Data from 116 T2DM patients were collected using a questionnaire about their socio-economic status, dietary patterns, outdoor activities, exercise, drug and supplement intake, occupation, and symptoms, which was filled out by the participants after written informed consent. Levels of serum vitamin D were estimated from the blood samples taken from the participants. Statistical analysis was done using MedCalc software. Results Vitamin D deficiency was found in 86 (74.14%) out of 116 diabetic patients. There were 63 males, and 71.43% of them had lower-than-normal vitamin D levels. The number of female participants was 53, and 77.36% were found to suffer from vitamin D deficiency. There were 88 obese participants, and only 22.73% were found to have sufficient levels of vitamin D. Conclusion The results depict a high prevalence of vitamin D deficiency in type 2 diabetes mellitus patients. Regular supplementation of vitamin D for diabetic patients can prevent them from developing any further complications. Increasing awareness about a healthy lifestyle, a proper diet, adequate sunlight, and exercise can help keep most non-communicable diseases at bay. Additional studies should be done to understand the pathophysiology better, which can aid in preventing diseases in the beginning stages of development.
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Nuclear factor erythroid-2-related factor 2 (Nrf2), an inducible transcription factor in phase II metabolic reactions, as well as xenobiotic response pathway, is referred to as 'master regulator' in anti-oxidant, anti-inflammatory, and xenobiotic detoxification processes. The activity of Nrf2 is tightly regulated by KEAP1, which promotes ubiquitination, followed by degradation under homeostatic conditions and also allows Nrf2 to escape ubiquitination, accumulate within the cell, and translocate in the nucleus upon exposure to the stresses. The Nrf2 pathway has shown an intrinsic mechanism of defense against oxidative stress (OS). It emerged as a promising therapeutic target as both inducers and as there is an increasing number of evidence for the protective role of the Nrf2-ARE pathway towards exacerbations of ROS generation as well as OS, mitochondrial dysfunction as well as prolonged neuroinflammation is a prevalent pathophysiological process rooted in brain-related disorders. Elevated concentrations of ROS generation and OS have been linked to the pathophysiology of a diverse array of brain related disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, Friedrich's ataxia, multiple sclerosis, and epilepsy. Further, it not only modulates the articulation of anti-oxidant genes but has often been associated with implicating anti-inflammatory consequences as well as regulating mitochondrial functionalities and biogenesis. Therefore, Nrf2 can be considered a potential therapeutic target for the regimen of various brain-related disorders.
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Antioxidantes , Fator 2 Relacionado a NF-E2 , Fator 2 Relacionado a NF-E2/genética , Fator 2 Relacionado a NF-E2/metabolismo , Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo , Antioxidantes/metabolismo , Xenobióticos , Zíper de Leucina , Espécies Reativas de Oxigênio/metabolismo , Transdução de Sinais , Estresse Oxidativo , Encéfalo/metabolismoRESUMO
Liver abscess is one of the conditions having multiple etiological agents. It can be parasitic or can be due to bacterial among other causes. Entamoeba histolytica is one of the common protozoan parasites causing amoebic liver abscess. So, accurate diagnosis is important for proper management and treatment. We have tried to detect the various bacterial etiological agents along with Entamoeba histolytica using culture of bacteria and polymerase chain reaction for E. histolytica in suspected liver abscess cases. Liver aspirates/pus collected from 63 patients were subjected to bacterial gram staining and culture along with wet mount and PCR for E. histolytica. Patients' clinical details and outcomes were also noted and co-related.It was seen that 22 (34.9%) out of 63 samples showed the presence of bacteria by gram staining whereas aerobic bacterial growth was seen in 28.6% and only 1.6% in anaerobic culture. Amoebic liver abscess showed E. histolytica in 36 patients out of 63 study participants (57.1%) by PCR. The study showed that 44.4% of patients had a habit of alcohol consumption and 19.1% were chronic smokers. Abdominal pain (90.3%) was the most common presenting feature followed by fever (64.5%). The most common co-morbidities in the enrolled patients was diabetes mellitus (19.3%) and least with chronic liver disease (3.2%). Liver abscess, a multi-etiological condition needs a robust diagnostic method. Just a single method or a single sample type is not sufficient to diagnose, as it may miss out other causes. Treating its associated co-morbidities may help to lessen it.
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Nicotianamine (NA) is one of the metal-chelating molecules found in higher plants in abundance. Synthesized by the enzyme nicotianamine synthase, NA has a major role in the transport of iron in plant tissues. This research paper deals with the coordination chemistry of the possible complexes of NA, [FeII (NA)]-, and [FeIII (NA)] in detail, from a theoretical standpoint. The chemical computations on the [FeII (NA)]- and [FeIII (NA)] complexes show that NA can bind with both Fe (+ 2) and Fe (+ 3) ions. The calculations confirm that the [FeIII (NA)] is thermodynamically more stable in comparison with [FeII (NA)]-, while [FeII (NA)]- is kinetically more stable than [FeIII (NA)]. Under the physiological conditions prevailing in plant tissues, [FeIII (NA)] can undergo reduction, but the auto-oxidation of [FeII (NA)]- to [FeIII (NA)] is prevented. In summary, NA can translocate Fe ions within plant tissues, wherever required, both as Fe (+ 2) and Fe (+ 3) complexes.
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Ácido Azetidinocarboxílico , Ferro , Ácido Azetidinocarboxílico/análogos & derivados , Ácido Azetidinocarboxílico/química , Ácido Azetidinocarboxílico/metabolismo , Ferro/metabolismo , Modelos Teóricos , PlantasRESUMO
Vegetable oil processing has been identified as one of the potential nonaqueous applications of membrane technology. Membrane-based processing has been largely attempted on individual steps of the conventional refining process with reasonable success. With the advent of organic-solvent-nanofiltration, membrane desolventizing of hexane oil miscella has received greater attention, revitalizing the prospects of integrated membrane processing. A practical evaluation of membrane augmented desolventizing revealed that approximately 65% energy savings towards solvent evaporation could be achieved in an industrial environment. Further, a pragmatic appraisal advocated that an integrated membrane process with a focus on pretreatment and desolventizing along with physical refining would be a desirable approach for fortifying the benefits. The present review intends to channelize the efforts to overcome the current limitations and highlights the importance of developing better membranes, process evaluation under appropriate practical conditions, and developing suitable cleaning protocols for stable performance. In the case of alternate solvents to hexane, membrane solvent recovery would be a favorable approach to overcome the limitation of associated higher thermal energy requirements. Nevertheless, solvent selection should be based on a composite evaluation of extraction and membrane desolventizing, specific to the type of oil. Finally, a comprehensive process scheme has been proposed to realize the benefits in extraction-refining plants. In this direction, a few pilot demonstration plants need to be established and operated for 1-2 years to understand and overcome the practical difficulties and limitations of the technology, leading to its industrial adoption.