RESUMO
Non-tuberculous mycobacteria (NTM) infections predominantly present as pulmonary disease. Although relatively rare, 20-30 % originate from extrapulmonary sites resulting in a wide range of clinical syndromes. Immunocompromised individuals are particularly susceptible. Clinical manifestations include skin and soft-tissue infections, lymphadenitis, musculoskeletal infections and disseminated disease. Diagnosing extrapulmonary NTM is challenging, and management is complex, often involving multiple radiological and microbiological investigations, long courses of combination antibiotic regimens and may require adjuvant surgical interventions. We highlight both the importance of involving NTM experts at an early stage and the role of a multidisciplinary approach in the diagnosis and management of these infections.
Assuntos
Clínicos Gerais , Humanos , Adjuvantes Imunológicos , Antibacterianos/uso terapêutico , Hospedeiro Imunocomprometido , Micobactérias não TuberculosasAssuntos
Injúria Renal Aguda/induzido quimicamente , Injúria Renal Aguda/epidemiologia , Antibacterianos/efeitos adversos , Infecções por Clostridium/tratamento farmacológico , Gentamicinas/efeitos adversos , Terapia de Substituição Renal , Injúria Renal Aguda/terapia , Antibacterianos/administração & dosagem , Gentamicinas/administração & dosagem , Humanos , Incidência , Modelos Estatísticos , Guias de Prática Clínica como Assunto , Estudos Retrospectivos , Reino UnidoRESUMO
The Hospital Pharmacy Initiative was a Department of Health funded programme in England between 2003 and 2006. It has produced a number of benefits that are organizational, educational, professional, clinical and economic. The opportunity to share experiences, identify what works well and collaborate across national boundaries to address a problem that is taxing all governments and NHS acute trusts and causes considerable concern to patients and their families should be a common goal for the UK.