Myoid Gonadal Stromal Tumor: A New Case Report with a Review of the Literature.

The myoid gonadal stromal tumor is a very rare testicular spindle cell tumor. Few cases have been reported in the literature from 1977 to 2022. It was an emerging entity in the fourth edition of the WHO Classification of Tumors of the Urinary System and Male Genital Organs and has been instated as a full benign entity in the new edition of 2022. We report herein an additional case of a myoid gonadal stromal tumor. It was a 27-year-old man who presented with an asymptomatic mass in his left testicle for 2 months. The mass was confirmed by ultrasound as a 3 cm solid well-circumscribed lesion for which orchiectomy has been performed. The histological analysis of the specimen and the immunohistochemistry staining was consistent with a myoid gonadal stromal tumor. The characteristics of this tumor are summarized in well-circumscribed, nonencapsulated masses of uniform spindle cells, and immunohistochemically, tumor cells coexpress SMA and S-100 protein. The benign behavior of this tumor is demonstrated by our results and those presented in the previous cases reported in the literature.

Pilomatrixoma mimicking a breast neoplasm: imaging finding in an uncommon case report.

Pilomatrixoma is a rare benign skin tumor originating from piliferous follicles, corresponding to a firm subcutaneous nodule requiring histology for diagnosis. Breast localization is considered to be very rare . Only few breast pilomatricomas have been reported, with imaging showing well defined nodules with microcalcifications, presenting as ACR BI-RADS 4 and 5, suspicious for a breast neoplasm . We report a case of pilomatrixoma of the left breast of a 33 year old woman, appearing as a firm, deep nodule in the lower outer quadrant.The lesion had mammographic and sonographic finding mimiking a breast cancer. Percutaneous biopsy was performed to confirm the histological diagnosis.

[Dysplasia in gastrointestinal mucosa: Interobserver variability and value of histological examination in the diagnosis of these lesions]. / Dysplasie en muqueuse digestive : étude de la variabilité interobservateurs et valeur de l'examen histologique dans le diagnostic de ces lésions.

Dysplasia is a preneoplastic lesion. Histological diagnosis is based on the presence of architectural and cytological modifications, and dedifferentiation, which the intensity is variable. Dysplasia is commonly graded as low and high grade. We achieved a retrospective study of 90 cases of gastrointestinal dysplasia collected in the Department of Pathology of Hassan II university hospital of Fez, during a period of 3 years. The cases were reviewed independently and blindly without clinical information by two pathologists. Their diagnoses were compared to the initial diagnosis. Interobserver concordance in the diagnosis of the degree of dysplasia was evaluated. The average age of our patients was 56 years oldwithout predominance of sex. The interobserver concordance in the diagnosis of digestive dysplasia between the three pathologists was moderate (with a Kappa estimated at 0.42). Concordant diagnosis for digestive low grade dysplasia was observed in 50 cases of the 55 cases (90%) and only 18 cases of high-grade dysplasia of 35 cases studied (50%). The agreement for the low-grade dysplasia is more significant. However, there is significant variation in the analysis of high-grade dysplasia. This work reveals a moderate reproducibility in the diagnosis of gastrointestinal dysplasia lesions and mostly well marked for high-grade dysplasia.