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1.
IEEE Trans Biomed Circuits Syst ; 18(1): 3-15, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37535484

RESUMO

We present the design, development, and experimental characterization of an active electrode (AE) IC for wearable ambulatory EEG recording. The proposed architecture features in-AE double common-mode (CM) rejection, making the recording's CMRR independent of typically-significant AE-to-AE gain variations. Thanks to being DC coupled and needless of chopper stabilization for flicker noise suppression, the architecture yields a super-T Ω input impedance. Such a large input impedance makes the AE's CMRR practically immune to electrode-skin interface impedance variations across different recording channels, a critical feature for dry-electrode ambulatory systems. Signal quantization and serialization are also performed in-AE, which enables a distributed system in which all AEs use a single data bus for data/command communication to the backend module, thus significantly improving the system's scalability. Additionally, the presented AE hosts auxiliary modules for (i) detection of an unstable electrode-skin connection through continuous interface impedance monitoring, (ii) dynamic measurement and adjustment of input DC level, and (iii) a CM feedback loop for further CMRR enhancement. The article also presents the development of printed (extrusion) tattoo electrodes and their experimental characterization results with the proposed AE architecture. Besides bio-compatibility, low-cost, pattern flexibility, and quick fabrication process, the printed electrodes offer a very stable electrode-skin connection, conform to scalp shape, and exhibit consistent performance under various bending curvatures. Analog circuit blocks of the presented AE architecture are designed and fabricated using a standard 180 nm CMOS technology, and the [Formula: see text] IC is integrated with off-chip low-power digital modules on a PCB to form the AE. Our measurement results show a CMRR of 82.2 dB (at 60 Hz), amplification voltage gain of 52.8 dB, a bandwidth of 0.2-400 Hz, ±500 mV input DC offset tolerance, An input impedance [Formula: see text], and 0.67 µV RMS integrated input referred noise (0.5-100 Hz), while consuming 17.5 µW per channel. All auxiliary modules are tested experimentally, and the entire system is validated in-vivo, for both ECG and EEG recording.


Assuntos
Amplificadores Eletrônicos , Processamento de Sinais Assistido por Computador , Desenho de Equipamento , Eletroencefalografia , Eletrodos
2.
J Chem Phys ; 159(2)2023 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-37449579

RESUMO

Inkjet-printed micro-patterns on hydrophobic surfaces have promising applications in the fabrication of microscale devices such as organic thin-film transistors. The low wettability of the surface prevents the inkjet-printed droplets from spreading, connecting to each other, and forming a pattern. Consequently, it is challenging to form micro-patterns on surfaces with low wettability. Here, we propose a sequential printing and drying method to form micro-patterns and control their shape. The first set of droplets is inkjet-printed at a certain spacing and dried. The second set of droplets is printed between these dry anchors on the surface with low wettability. As a result, a stable bridge on the surface with low wettability forms. This printing method is extended to more complicated shapes such as triangles. By implementing an energy minimization technique, a simple model was devised to predict the shape of the inkjet-printed micro-patterns while confirming that their equilibrium shape is mainly governed by surface tension forces. The gradient descent method was utilized with parametric boundaries to emulate droplet pinning and wettability of the anchors and to prevent convergence issues from occurring in the simulations. Finally, the energy minimization based simulations were used to predict the required ink to produce dry lines and triangles with smooth edges.


Assuntos
Molhabilidade , Tensão Superficial
3.
IEEE Trans Biomed Circuits Syst ; 14(6): 1274-1286, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32976106

RESUMO

This paper presents an energy-efficient mm-scale self-contained bidirectional optogenetic neuro-stimulator, which employs a novel highly-linear µLED driving circuit architecture as well as inkjet-printed custom-designed optical µlenses for light directivity enhancement. The proposed current-mode µLED driver performs linear control of optical stimulation for the entire target range ( 10 mA) while requiring the smallest reported headroom, yielding a significant boost in the energy conversion efficiency. A 30.46× improvement in the power delivery efficiency to the target tissue is achieved by employing a pair of printed optical µlenses. The fabricated SoC also integrates two recording channels for LFP recording and digitization, as well as power management blocks. A micro-coil is also embedded on the chip to receive inductive power and our experimental results show a PTE of 2.24 % for the wireless link. The self-contained system including the µLEDs, µlenses and the capacitors required by the power management blocks is sized 6 mm 3 and weighs 12.5 mg. Full experimental measurement results for electrical and optical circuitry as well as in vitro measurement results are reported.


Assuntos
Neuroestimuladores Implantáveis , Optogenética/instrumentação , Tecnologia sem Fio/instrumentação , Humanos , Modelos Biológicos
4.
Microsyst Nanoeng ; 2: 16032, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-31057829

RESUMO

We combined lightweight and mechanically flexible printed transistors and actuators with a paper unmanned aerial vehicle (UAV) glider prototype to demonstrate electrically controlled glide path modification in a lightweight, disposable UAV system. The integration of lightweight and mechanically flexible electronics that is offered by printed electronics is uniquely attractive in this regard because it enables flight control in an inexpensive, disposable, and easily integrated system. Here, we demonstrate electroactive polymer (EAP) actuators that are directly printed into paper that act as steering elements for low cost, lightweight paper UAVs. We drive these actuators by using ion gel-gated organic thin film transistors (OTFTs) that are ideally suited as drive transistors for these actuators in terms of drive current and frequency requirements. By using a printing-based fabrication process on a paper glider, we are able to deliver an attractive path to the realization of inexpensive UAVs for ubiquitous sensing and monitoring flight applications.

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