RESUMO
The experiments on white outbred awaken male rats have shown that derivatives of adamant-2-ylamides of alkylamidocarbonic acids exhibit prominent antiarrhythmic (antifibrillatory) effect on the model of calcium chloride arrhythmia. The most pronounced effect was demonstrated by N-[2(adamant-2-yl)aminocarbonylmethyl]-N'-[3-(diethylamino)propyl]-4-nitrobenzamide. This compound was also active on the model of aconitine arrhythmia, which is characteristic of class-I antiarrhythmic agents. It is established that N-[2-(adamant-2-yl)aminocarbonylmethyl]-N'-[3-(diethylamino)propyl]-4-nitrobenzamide has prominent antiarrhythmic activity and is more safe than other antiarrhythmic drugs of class I (lidocaine, ethmosine, novocainamide), class IV (verapamil), and class III (cardiocyclide).
Assuntos
Adamantano/análogos & derivados , Adamantano/farmacologia , Antiarrítmicos/farmacologia , Arritmias Cardíacas/tratamento farmacológico , Benzamidas/farmacologia , Aconitina/efeitos adversos , Aconitina/farmacologia , Adamantano/química , Animais , Arritmias Cardíacas/induzido quimicamente , Arritmias Cardíacas/fisiopatologia , Benzamidas/química , Masculino , Ratos , Agonistas do Canal de Sódio Disparado por Voltagem/efeitos adversos , Agonistas do Canal de Sódio Disparado por Voltagem/farmacologiaRESUMO
Afobazole pharmacokinetics upon oral administration of tablets prepared according to various technologies was studied in rabbits. The main pharmacokinetic parameters were determined.