[The historical aspects of development of concept of endometriosis: publications review].

The endometriosis is a chronic gynecological disease, etiology and pathogenesis of which are not fully clear to science. Its consequences are hardest burden for health care, society and every female patient and her family. The presented review tries to answer in historical aspect the question of interest to all scientists - why endometriosis, known to science for more than 300 years, still remains "disease of riddles and assumptions"? The search of publications was implemented in such databases as Web of Science, eLibrary, Scopus, PubMed/MEDLINE. The search was based on keywords "history", "endometriosis", "review", "myths", "authorship", "infertility", "reproductive dysfunction". The study covered full-text sources and publications reviews related to subject under study. The articles having no direct relation to the topic of endometriosis were excluded from the review. The review demonstrated that as before pathogenesis of endometriosis remains enigmatic and complex. The more and more evidences appear that endometriosis is part of syndrome of uterus reproductive dysfunction. Hence necessity in further research and experimental designs in this area. Perhaps in nearest future scientists nevertheless will find the clue to single etiopathogenetic mechanism of development of endometriosis which at a later date will be successfully applied by physicians in diagnostic and treatment of this disease.

[The prediction of the membrane-damaging action of chemical substances in experiments on bacteria]. / Prognozirovanie membranopovrezhdaiushchego deistviia khimicheskikh veshchestv v opytakh na bakteriiakh.

Comparative study of the cytoplasmic membrane sensitivity in procaryotic cells (E. coli) and eucaryotic cells (rat red blood cells) to bis-quaternary ammonea compounds and diatomic aliphatic alcohols was carried out. Comparative study of the membrane permeability demonstrated, that E. coli is more sensitive for these xenobiotics. Cells of E. coli recommended as a biotest-object for the membrane tropic toxic reactions to study.

[Adaptation of pathogens of purulent infections to surface-active antiseptics]. / Adapatsionnye vozmozhnosti vozbuditelei gnoinoi infektsii k poverkhnostno-aktivnym antisepticheskim sredstvam.

A comparative study was carried out of adaptative capacities of microorganisms to antiseptic agents from the group of cationic surface-active substances (SAS) and antibiotics. It was established that antiseptic agents from SAS group may induce the appearance of resistant to them populations of microorganisms. The resistance acquired to one of the surface-active antiseptics spreads to other agents of this group. At the same time, cationic SAS reduce the frequency and rate of appearance of antibiotico-resistant populations of bacteria during combined use with antibiotics.

[Effect of corticotropin on the dehydrogenase activity of cells and tissues]. / Vliianie kortikotropina na degidrogenaznuiu aktivnost' kletok i tkanei.

The authors studied the effect of native ACTH on dehydrogenase activity of isolated strips of rat diaphragm and suspension of E. coli cells, serotype O III:B4, grown on beef extract agar in a medium with different dehydrogenation substrates. ACTH activated dehydrogenase of rat diaphragm in a medium containing pyruvate, alpha-ketoglutarate, malate, beta-hydroxybutyrate, D-aspartic acid and did not alter it in a medium containing succinate. In contradistinction to rat diaphragm, ACTH activated dehydrogenase of E. coli cells whatever the substrates used (oxaloacetate, isocitrate, alpha-ketoglutarate, succinate, fumarate, malate, pyruvate, lactate, beta-hydroxybutyrate, glucose, D-aspartic acid. Synacthen (ACTH1-24) exerted a similar effect. It is suggested that the effects of ACTH are mediated via its influence on adenylate cyclase in the absence of receptors.

[The effect of corticotropin and hydrocortisone on the dehydration of Krebs cycle substrates in E. coli cells]. / Vliianie kortikotropina i gidrokortizona na degidrirovanie substratov tsikla Krebsa trikarbonovykh kislot v kletkakh E. coli.

Corticotropin and hydrocortisone were studied for their effect on dehydrogenase activity of microbial E. coli cells in the medium with the tricarboxylic acid cycle substrates, glucose and beta-oxybutyric acid. Corticotropin, as distinct from hydrocortisone, is shown to increase the dehydrogenase activity of microbial cells when pyruvate, isocitrate, oxaloacetate, alpha-ketoglutarate, succinate, furmarate, glucose and beta-oxybutyrate are used as substrates. Hydrocortisone induced a rise of the dehydrogenase activity of microbial cells only in the medium with isocitrate, alpha-ketoglutarate and fumarate, however to a less extent than corticotropin; it lowered this activity in the medium with pyruvate and glucose and did not change it with oxaloacetate, succinate and beta-oxybutyrate. The corticotropin effect is supposed to be extra-adrenal because microbial cells are also subjected to its action.

[Joint action of ethonium and antibiotics on gram-positive and gram-negative microorganisms]. / Sovmestnoe deistvie étoniia i antibiotikov na grampolozhitel'nye i gramotritsatel'nye mikroorganizmy.

The inhibitory effect of antibiotics and their combinations with ethonium was studied in vitro with 10 strains of Staph. aureus and 10 strains of E. coli, Sh. sonnei and Pr. morganii. Ethonium is an antimicrobial drug of the group of cationic surface-active substances. The study was performed with the method of serial dilutions in a liquid nutrient medium. It was found that under the effect of the subbacteriostatic concentrations of ethonium, sensitivity of the microorganisms to benzylpenicillin, streptomycin, levomycetin and tetracycline increased 4-16, 2-8, 2-32 and 64-256 times, respectively. Along with the increasing of the antibiotic activity, ethonium promoted a decrease in the rate of the Staph. aureus adaptation to the above antibiotics.