Harnessing the cobalt complex for bidirectional O2/H2O transformation in neutral water via electrocatalysis/photocatalysis.

Bidirectional oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalysts are crucial for renewable energy transduction via electrolyzers and fuel cell. Here, we present a protocol for harnessing the cobalt complex for bidirectional O2/H2O transformation in neutral water via electrocatalysis/photocatalysis. We describe steps for monitoring ORR and OER in neutral aqueous solution, measuring O2 concentration, and identifying the probable catalytic mechanism for ORR and OER. We then detail procedures for examining catalyst behavior under photocatalytic conditions in neutral aqueous surroundings. For complete details on the use and execution of this protocol, please refer to Saini et al.1.

A homogeneous cobalt complex mediated electro and photocatalytic O2/H2O interconversion in neutral water.

The O2/H2O redox couple is vital in various renewable energy conversion strategies. This work delves into the Co(L-histidine)2 complex, a functional mimic of oxygen-carrying metalloproteins, and its electrochemical behavior driving the bidirectional oxygen reduction (ORR) and oxygen evolution (OER) activity in neutral water. This complex electrocatalyzes O2 via two distinct pathways: a two-electron O2/H2O2 reduction (catalytic rate = 250 s-1) and a four-electron O2 to H2O production (catalytic rate = 66 s-1). The formation of the key trans-µ-1,2-Co(III)-peroxo intermediate expedites this process. Additionally, this complex effectively oxidizes water to O2 (catalytic rate = 15606 s-1) at anodic potentials via a Co(IV)-oxo species. Additionally, this complex executes the ORR and OER under photocatalytic conditions in neutral water in the presence of appropriate photosensitizer (Eosin-Y) and redox mediators (triethanolamine/ORR and Na2S2O8/OER) at an appreciable rate. These results highlight one of the early examples of both electro- and photoactive bidirectional ORR/OER catalysts operational in neutral water.

Oroesophageal Pemphigus vulgaris Secondary to Lisinopril Use: A New Side Effect.

Pemphigoid diseases are a group of blistering autoimmune pathologies including pemphigus vulgaris (PV) and pemphigus foliaceous, which affect mucocutaneous tissues. Non-steroidal anti-inflammatory drugs, penicillamine, and angiotensin-converting enzyme inhibitors such as captopril and enalapril are associated with drug-induced pemphigoid. We present a case of lisinopril-associated PV which has not been previously reported.

A Preliminary Report of COVID-19 in Children in India.

We describe the profile of COVID-19 in children from India in this multicentre observational study from tertiary care hospitals in West Bengal. Data of children up to 12 years presenting with positive results on SARS-CoV-2 RT-PCR test were included. The median (IQR) age of the 41 patients included was 1 (0.42-5.0) year. Eleven (26.8%) patients, including 6 neonates, never showed any symptoms. Fever was seen in only 9 patients (21%), and co-morbities were found in 61% of patients. There was one death.

Senile Systemic Amyloidosis Presenting as Hematuria: A Rare Presentation and Review of Literature.

INTRODUCTION: Senile systemic amyloidosis is a multisystem disease where wild-type insoluble transthyretin (ATTRwt) protein gets deposited in the tissues leading to organ dysfunction. METHODOLOGY: We present the case of a patient who presented with hematuria and bladder involvement by ATTRwt amyloidosis who ultimately died of multiorgan failure. RESULTS: The patient was an 82-year-old white male with a history of ischemic cardiomyopathy (ejection fraction (EF): 20-25%), chronic atrial fibrillation, chronic kidney disease (CKD), and carpal tunnel syndrome who presented with acute hematuria, urinary retention, and progressive fatigue. He underwent cystoscopy and bladder biopsy which was positive on congo-red stain diagnostic for amyloidosis. Echocardiogram demonstrated worsening of EF to 10-15% and concentric left ventricle hypertrophy. MRI was not performed due to underlying CKD. His condition deteriorated during the hospital stay, and he developed cardiogenic shock and progressive liver dysfunction. Infectious workup was negative. Meanwhile, the biochemical investigations (serum protein electrophoresis, immunofixation, and urine kappa/lambda chains) ruled out plasma cell dyscrasias. Mass spectrometry analysis of the bladder biopsy specimen confirmed wild-type transthyretin (ATTRwt) amyloidosis consistent with senile systemic amyloidosis. Due to patients' extremely poor prognosis, his family wished to focus on patient's comfort-oriented measures only, and patient passed away shortly thereafter. CONCLUSION: Senile systemic amyloidosis can rarely present in an atypical fashion such as hematuria. The treatment options are limited in this disease process. Novel therapies are in the early phases of development. Concern also exists that in patients with multiple comorbidities, this entity is under recognized until the more advanced stages.

Joint scores in hemophilic arthropathy in children: Developing country perspectives.

OBJECTIVE: Hemophilia is a common X-linked recessive coagulopathy causing recurrent bleeding into the synovial joints and results in articular and periarticular abnormalities. To our knowledge, this is the first comprehensive study aimed at studying the clinico-radiological joint score evaluation in hemophilic arthropathy in children from a developing country and its possible impact on the quality of life. METHODS: In this hospital-based, prospective, descriptive study, all children presenting to the pediatric rheumatology clinic were studied. The joint physical examination was scored using the Hemophilia Joint Health Score 2.1 (HJHS 2.1). The patients were then subjected to imaging of the most affected joint using ultrasonography (USG) and magnetic resonance imaging (MRI). Detailed USG and MRI radiological evaluation was recorded in the predesigned proforma using the Hemophilia Early Arthropathy Detection with Ultra Sound (HEAD-US) score and MRI DENVER score. The physical quality of life as per Functional Independence Score in Hemophilia (FISH) was noted. The clinical, radiological, and functional scores were analyzed with an appropriate statistical measure. RESULTS: The mean age at presentation was 7.4 years (interquartile range 4.9-10), with the knee being the most common joint involved. All of the USG score, MRI score, and FISH score have a significant correlation (p<0.05), with the HJHS 2.1 score with correlation coefficients of 0.7086, -0.8916, and 0.8607, respectively. USG and MRI had a correlation coefficient of -0.7145 and -0.8326 with FISH, respectively. CONCLUSION: The degree of association between HJHS 2.1 score was found to be maximum with HEAD-US score, whereas a negative correlation was seen evaluating FISH score with both HEAD-US and MRI DENVER scores. Use of these scores, specifically HEAD-US score, will result in consistent assessment of hemophilic joints, optimizing the management of the destructive changes.

Evolution of clinical method for new-born infant maturity assessment.

In the routine practice of neonatology, differentiating preterm premature new-born from small-for-date (SFD) new-born infant is an essential aspect to anticipate different clinical scenarios and monitor accordingly. Clinical assessment of new-born maturity is an invincible tool in resource poor areas for the purpose, without any prior investment. Over the past decades, clinical method for new-born infant maturity assessment has evolved intricately. From defining prematures with a mere statement of birth weight to clinical assessment of new-born as per gestational age with a comprehensive scheme based on neural and physical maturity characteristics of a new-born, clinical method for new-born maturity assessment has evolved substantially to the present where we stand. A complete review on the evolutionary history of clinical method for new-born infant maturity assessment will enable researchers in this field to get acquainted with the trend of past research work in accordance to the recent advancement all over the world. In the process, the lacunae still present in this area of study can be spotted which will invite new research proposals. Looking into the recent context, clinical method for assessing new-born infant maturity is making further forward shift with an attempt to quantify neuromuscular maturity criteria with further precision and incorporation of additional criteria."What is known - What is New" (Authors' summary)What is knownNeuro-muscular and external physical characteristic assessment together has greater significance for evaluating new-born infant's maturity as per gestational age over using individual one of them.Evaluation of brain maturity through passive muscle tone assessment of new-born infants with different maneuvers has the imperative role in determining new-born infant maturity.What is newClinical method for determining new-born infant maturity as per gestational age is being made explicit with the incorporation of criteria like feeding behavior of the new-born and objective assessment of anthropometric parameters, beside neuro-muscular and external physical characteristics evaluation.Neuro-muscular maturity can be quantified further with absolute values or closer range of values of different maneuvers and signs used in the clinical method for evaluating new-born infant maturity as per gestational age with more precision.

Complete Endoscopic and Histopathological Remission of Mantle Cell Lymphoma of the Gastrointestinal Tract.

Mantle cell lymphoma (MCL) is a rare and incurable subtype of non-Hodgkin's lymphoma (NHL). Primary gastrointestinal (GI) MCLs are even rarer, accounting for only 1%-4% of GI lymphomas. We describe a case of a 77-year-old female who presented with complaints of indigestion and abdominal bloating. An upper endoscopy was performed which revealed a duodenal bulb polyp, biopsies of which were consistent with MCL. She was initially observed without any chemotherapy; however, a repeat endoscopy two years later revealed that she now also had MCL of the ileocecal valve. The patient was initiated on treatment with rituximab, cyclophosphamide, vincristine, and prednisone (R-CVP). She underwent regular surveillance with her oncologist after completion of her chemotherapy and repeat surveillance scans remained negative for any recurrence. A repeat upper endoscopy with endoscopic ultrasound and colonoscopy were performed which showed complete endoscopic and histopathological remission of her lymphoma. Patients with MCL typically have a poor prognosis; however, our patient remains symptom free and in complete remission six years from her initial diagnosis.

Abandoned Babies at Tertiary Care Rural Medical College Hospital: The Indian Scenarios.

OBJECTIVES: In India, girls are sex-selectively abandoned. The abandoned babies are brought to the nearest hospital under the jurisdiction of the administration. The authors aimed to study the demographic data and disease profile of those babies. METHODS: In this hospital-based, retrospective, descriptive study, authors studied all the abandoned babies who were admitted to the Department of Pediatrics as "unknown" and cared for over the last 3 y. Their case records were analyzed with an appropriate statistical measure. RESULTS: Out of 11 babies, girl-boy ratio was 2.6:1, 73% being abandoned in the neonatal period with a survival rate of 91%. Six babies (54.5%) required emergency intervention at admission. Hospital stay was higher in girls with mean discharge time being 106 d, although the mean fit for discharge time was 6.5 d. CONCLUSIONS: This study is the first of its kind on abandoned babies demographic data and disease profile, highlighting the burden of abandoned babies in the hospital.