1.
J Chromatogr Sci
; 39(1): 21-8, 2001 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11206910
RESUMO
This study describes how scale-up in countercurrent chromatography (CCC) can be simply predicted on a process scale CCC device by running a preliminary analytical-sized sample and having knowledge of the stationary-phase retention at scale-up conditions. Results have shown that simple experimentation can lead within a day to a process with the capability of several kilograms per day (tons per year) compound yield, and that this is feasible with benchtop CCC units.