Assuntos
Comportamento Animal/efeitos dos fármacos , Clorpromazina/uso terapêutico , Cocaína/toxicidade , Diazepam/uso terapêutico , Propranolol/uso terapêutico , Animais , Cocaína/antagonistas & inibidores , Hemodinâmica/efeitos dos fármacos , Infusões Parenterais , Macaca fascicularis , Masculino , Convulsões/induzido quimicamenteAssuntos
Pressão Sanguínea/efeitos dos fármacos , Vasopressinas/farmacologia , Animais , Cães , Retroalimentação , Hematócrito , Hemorragia/etiologia , Nefrectomia , Norepinefrina/farmacologia , Concentração Osmolar , Potássio/sangue , Reflexo Anormal/fisiopatologia , Sódio/sangue , Medula Espinal/fisiopatologia , Vasopressinas/sangueAssuntos
Metadona/análogos & derivados , Acetato de Metadil/toxicidade , Animais , Antipirina/metabolismo , Temperatura Corporal/efeitos dos fármacos , Meia-Vida , Haplorrinos , Frequência Cardíaca/efeitos dos fármacos , Macaca mulatta , Masculino , Respiração/efeitos dos fármacos , Fatores de TempoRESUMO
LAAM was administered intravenously to conscious dogs at doses of either 0.1, 0.3 or 1.0 mg/kg. Cardiopulmonary responses were measured prior to drug administration, 0.5 hr post-drug and hourly thereafter. All doses produced a sleep-like state which was dose-related in duration (3-14 hr). Cardiac output, heart rate, respiratory rate and minute volume were decreased below mean pre-drug control values after drug administration in the two higher dosage groups; cardiac output in both groups failed to return to pre-drug control levels. Additionally, total peripheral resistance was elevated in these dosage groups although mean arterial pressure remained stable. Arterial pCO2 increased and arterial pH decreased as respiratory rate and minute volume decreased. Depression of rectal temperature occurred only in response to the highest dose.