RESUMO
Introduction Acute appendicitis is a common reason for acute abdominal pain. It has a high perforation rate of 20%. Diagnosis of acute appendicitis is usually through well-known clinical signs and symptoms. Radiologic imaging is by and large carried out in peculiar cases with indistinct signs and symptoms. Although various scoring methods are available for screening and diagnosis, those have inadequate validity to accurately predict the severity of acute appendicitis. From the differential counts, the neutrophil-to-lymphocyte ratio (NLR) is an economical and straightforward measure of subclinical inflammation. NLR may be a useful marker for predicting the onset and severity of appendicitis because of the insight it gives into immunological and inflammatory pathways. In this study, we aimed to determine the association between NLR and acute appendicitis among adult patients to differentiate between perforated and non-perforated appendicitis in a tertiary care hospital in Tamil Nadu, India. Methods This was a cross-sectional study conducted in the Department of General Surgery of a deemed university in Chennai, Tamil Nadu. The study was conducted from March 2022 to December 2022. Patients aged 18 years and above undergoing appendicectomy surgery were included in the study. Patients with hematology disorders, chronic kidney disease, chronic liver disease, chronic obstructive pulmonary disease, asthma, cancer, or auto-immune diseases, and any viral, bacterial, or parasitic infections were excluded. Pregnant women were also excluded from the study. After obtaining informed consent from the patients, blood samples were collected as and when they were diagnosed as acute appendicitis. Laboratory analysis for complete hemogram including white blood cell (WBC) count, neutrophil, and lymphocyte count was carried out using an automated hematology analyzer. Prevalence of perforated appendicitis was reported as a percentage. The receiver-operating characteristic (ROC) curve was developed for NLR in differentiating perforated and non-perforated appendicitis. Data were entered in Microsoft Excel 2023. These analyses were carried out in STATA 12.0 (StataCorp, College Station, Texas, USA). Results A total of 212 patients aged 18 years and above were included in the study. Among them 93 (43.9%) were male and 119 (56.1%) were female. Prevalence of perforated appendicitis observed intra-operatively was 29.7% and non-perforated appendicitis was 70.3%. The mean (SD) of NLR among patients with perforated appendicitis was 8.8 (5.1) and non-perforated appendicitis was 3.2 (2.4) with a statistically significant difference (p-value < 0.0001). ROC curve with a cut-off value of 3.78 NLR, had sensitivity of 65.9% and specificity of 93.1% in differentiating perforated and non-perforated appendicitis. The positive predictive value (PPV) and negative predictive values (NPV) were reported as 85.7% and 81.2%, respectively. Conclusion NLR has a reasonable validity in differentiating perforated and non-perforated appendicitis. NLR may be useful in low-resource settings where routine confirmatory radiological procedures like computed tomography scans are not available.
RESUMO
Background Inguinal hernia is one of the most common conditions in India, and history has many repair techniques recorded in it. Postoperative pain still remains a problem despite tension-free hernioplasty being accepted as the gold standard. Increased duration of surgery not only exposes the patient to unwanted increased chances of mesh infection but also reduces the surgeon's productivity if continued persistently. In this study, the main aim was to compare the fixation techniques of polypropylene mesh vs. self-gripping mesh in inguinal hernia surgery in terms of duration of surgery, postoperative pain, seroma, recurrence, foreign body sensation, and wound infections. Methods It is a prospective, comparative, and quantitative study conducted at Sri Ramachandra Institute of Higher Education and Research in the Department of General Surgery. Patients presenting with inguinal hernia to the OPD were included in the study. The sampling technique used in this study is simple, convenient sampling. As a result, the calculation of the margin of error and confidence levels may be difficult. Nevertheless, the sample accurately represents the population. Patients were divided into two groups: the study group (25), patients undergoing hernioplasty with self-gripping mesh, and the control group (25), patients undergoing hernioplasty with polypropylene mesh using conventional suturing. The duration of surgery, postoperative pain, seroma, recurrence, foreign body sensation, and wound infections were compared and analyzed between the two groups. Results In this study, the duration of surgery was less than one hour for three patients (12%) in the control group (polypropylene), compared to 13 (52%) patients in the study group (self-gripping), which is statistically significant. The early postoperative pain on POD 0 was greater than 4 (visual analogue score) in 8 (32%) patients in the control group and two (8%) patients in the study group. There were no significant differences in chronic pain, recurrence rate, seroma rate, or wound infection between the two groups. Conclusions In our study, we conclude that self-gripping mesh is superior to polypropylene mesh in surgery of inguinal hernia in terms of shorter duration of surgery. There is also reduced pain in the immediate postoperative period though not statistically significant. There is no significant difference in both the groups in terms of seroma formation, wound infection, foreign body sensation, and recurrence.