Two waves of massive stars running away from the young cluster R136.

Massive stars are predominantly born in stellar associations or clusters1. Their radiation fields, stellar winds and supernovae strongly impact their local environment. In the first few million years of a cluster's life, massive stars are dynamically ejected and run away from the cluster at high speed2. However, the production rate of dynamically ejected runaways is poorly constrained. Here we report on a sample of 55 massive runaway stars ejected from the young cluster R136 in the Large Magellanic Cloud. An astrometric analysis of Gaia data3-5 reveals two channels of dynamically ejected runaways. The first channel ejects massive stars in all directions and is consistent with dynamical interactions during and after the birth of R136. The second channel launches stars in a preferred direction and may be related to a cluster interaction. We found that 23-33% of the most luminous stars initially born in R136 are runaways. Model predictions2,6,7 have significantly underestimated the dynamical escape fraction of massive stars. Consequently, their role in shaping and heating the interstellar and galactic media and their role in driving galactic outflows are far more important than previously thought8,9.

Inhibition of mitochondrial function by approved drugs overcomes nasopharyngeal carcinoma chemoresistance.

The development of chemo-resistance in nasopharyngeal carcinoma (NPC) presents a significant therapeutic challenge, and its underlying mechanisms remain poorly understood. In our previous studies, we highlighted the association between isoprenylcysteine carboxylmethyltransferase (ICMT) and chemoresistance in NPC. In this current research, we revealed that both 5-FU and cisplatin-resistant NPC cells exhibited elevated mitochondrial function and increased expression of mitochondrial genes, independent of ICMT. Our investigations further showed that classic mitochondrial inhibitors, such as oligomycin, antimycin, and rotenone, were notably more effective in reducing viability in chemo-resistant NPC cells compared to parental cells. Moreover, we identified two antimicrobial drugs, tigecycline and atovaquone, recognized as mitochondrial inhibitors, as potent agents for decreasing chemo-resistant NPC cells by targeting mitochondrial respiration. Remarkably, tigecycline and atovaquone, administered at tolerable doses, inhibited chemo-resistant NPC growth in mouse models and extended overall survival rates. This work unveils the efficacy of mitochondrial inhibition as a promising strategy to overcome chemo-resistance in NPC. Additionally, our findings highlight the potential repurposing of clinically available drugs like tigecycline and atovaquone for treating NPC patients who develop chemoresistance.

Monodispersed Transition Metals Induced Ordinary-Pressure Phase Transformation from Graphite to Diamond: A First-Principles Calculation.

High pressure and high temperature are normally required for the transformation of graphite to diamond; thus, finding a method that allows the transformation to occur under ordinary pressure will be extremely promising for diamond synthesis. Here, it is found that graphite spontaneously transforms into diamond without any pressure by adding monodispersed transition metals, and the universal rules that will help predict the role of certain elements in the phase transition were studied. The results show that the favorable transition metals possess an atomic radius of 0.136-0.160 nm and an unfilled d-orbital of d2s2-d7s2, which allow more charge transfer and accumulation at the proper position between the metal and dangling C atoms, leading to stronger metal-C bonds and a lower energy barrier for the transition. This provides a universal method to prepare diamond from graphite under ordinary pressure and also provides a way for the synthesis from sp2 to sp3 bonded materials.

Diamond formation mechanism in chemical vapor deposition.

It is a key challenge to prepare large-area diamonds by using the methods of high-pressure high-temperature and normal chemical vapor deposition (CVD). The formation mechanism of thermodynamically metastable diamond compared to graphite in low-pressure CVD possibly implies a distinctive way to synthesize large-area diamonds, while it is an intriguing problem due to the limitation of in situ characterization in this complex growth environment. Here, we design a series of short-term growth on the margins of cauliflower-like nanocrystalline diamond particles, allowing us to clearly observe the diamond formation process. The results show that vertical graphene sheets and nanocrystalline diamonds alternatively appear, in which vertical graphene sheets evolve into long ribbons and graphite needles, and they finally transform into diamonds. A transition process from graphite (200) to diamond (110) verifies the transformation, and Ta atoms from hot filaments are found to atomically disperse in the films. First principle calculations confirm that Ta-added H- or O-terminated bilayer graphene spontaneously transforms into diamond. This reveals that in the H, O, and Ta complex atmosphere of the CVD environment, diamond is formed by phase transformation from graphite. This subverts the general knowledge that graphite is etched by hydrogen and sp3 carbon species pile up to form diamond and supplies a way to prepare large-area diamonds based on large-sized graphite under normal pressure. This also provides an angle to understand the growth mechanism of materials with sp2 and sp3 electronic configurations.