RESUMO
Recently, magnetic field (MF) has been described as a potential way to improve the properties of electrode materials, which significantly enhances the ion diffusion behavior and material wettability. We first synthezised for the first time a comparable carbon-based electrode material (GCA) including active carbon, reduced graphene and carbon nanotubes through a facile stirring method for further research under MF. Herein, 0.15 T of MF induced by two NdFeB magnets was applied on the supercapacitor devices to enhance the energy density, which increased by about 62% for the symmetric supercapacitor (SSC: from 11.2 to 18.1 W h kg-1). An asymmetric supercapacitor composed of the prepared GCA as the anode and NiCoFe/NiCoFe-OH as the cathode was also assembled for research. And it was found that the whole electrochemical performance significantly improved (for example, energy density increased by about 22% for the asymmetric supercapacitor, i.e., from 50.6 to 61.4 W h kg-1).
RESUMO
OBJECTIVES: To determine the correlation between fms-like tyrosine kinase 3 gene (FLT3) expression and FLT3-internal tandem duplication (ITD) mutations in acute myeloid leukemia patients,and the association between expression of FLT3 gene and clinical and laboratory features of patients. METHODS: The expression of FLT3 mRNA in bone marrow (BM) leukemic cells of 128 acute myeloid leukemia (AML) patients was measured by real-time PCR.The patients were divided into two groups using the 35% FLT3 expression as a cut-off point.The associations between the expression level of FLT3 and clinical and laboratory features of patients were analyzed. RESULTS: The patients had a FLT3 gene expression level of 0.01-180.68 (mean 14.65) at the initial diagnosis,with AML-M1 the most expressed and AML-M6 the least expressed,but without statistical significance.The patients with a high level of FLT3 gene expression had higher peripheral blood white blood cell count (WBC) (P<0.01) and were more likely to become anemic and febrile (P<0.05).WBC [regression coefficient (B)=1.508,odds ratio (OR)=4.518,95% confidence interval(CI):1.465-13.390,P=0.009] and anemia (B=2.142,OR=8.513,95%CI:3.201-22.644,P<0.001)were predictors of higher expression of FLT3.The patients with high levels of FLT3 gene expression had lower complete remission rate (32/83),compared with those (36/44) with low levels of FLT3 gene expression (P<0.05).The Cox regression analysis showed that the patients with higher levels of FLT3 gene expression had a higher risk of death (B=1.338, relative risk=3.810, 95%CI:1.820-7.947,P<0.001).The Kaplan-Meier analysis showed that the patients with higher levels of FLT3 gene expression had lower survival time (56.63%) than those with lower levels of FLT3 expression (70.45%,P<0.05). CONCLUSIONS: FLT3 gene has adverse impacts on complete remission of AML.High expression of FLT3 gene is associated with poor prognosis of patients with AML.