Progressive Relationship Between Sustainable Development of Elderly Care Institutions and Spatial Environmental Factors: A Study Based on the Influence of Supermarkets, Medical Accessibility, and Parks in Urban Areas.

Purpose: To study the relationship between three variables, namely, the number of supermarkets around, the average distance to medical institutions designated to be covered by basic medical insurance, and the presence of parks around, and the sustainable development of elderly care institutions. Patients and Methods: This paper is based on the census database of elderly care institutions in Beijing. We ran a self-developed Python program to mine the database after adding three variables, namely, the number of supermarkets around, the average distance to medical institutions designated to be covered by basic medical insurance (hereinafter referred to as "designated medical institutions"), and the presence of parks around, and then used the least squares method in regression analysis. Results: The number of years of depreciation for fixed assets had some degree of influence on the occupancy rate of an elderly care institution under sustained operation. The occupancy rate of above 80% was efficient for an elderly care institution. There was a progressive relationship between the external spatial factors and the internal resources of an elderly care institution in terms of influencing the occupancy rate of the institution. Optimizing the spatial distribution of elderly care institutions should first optimize the choice of location. Conclusion: The occupancy rate of an elderly care institution was closely related to the convenience of living conditions and that site selection was crucial for such a facility. We arrived at two recommendations for the future development of elderly care institutions, 1. Reducing the number of the institutions in areas with unfavorable geographic positions and serving senior care needs within an appropriate close distance, so as to better optimize the spatial distribution of senior care facilities, improve the efficiency of resource allocation. 2. Strike a balance between the economic benefits of operating entities and the social benefits associated with older people.

Surface imprinted core-shell nanorod for selective extraction of glycoprotein.

In this paper, combining phenylboronic affinity, surface imprinting, and magnetic Fe3O4, a novel surface imprinted core-shell nanorod (Fe3O4@SiO2/MIPs) was developed for glycoprotein extraction. The Fe3O4@SiO2/MIPs was prepared in water solution using dopamine as functional monomer. The Fe3O4@SiO2/MIPs showed high binding capacity (175.2 mg/g) and fast mass transfer rate (40 min) toward the template protein (ovalbumin, OVA). In addition, the successful extraction of OVA from egg white confirmed the outstanding selectivity of the obtained material. All these results demonstrated that the Fe3O4@SiO2/MIPs had broad application prospects in glycoprotein recognition, biomedical research and clinical diagnosis.

Molecularly imprinted colloidal array with multi-boronic acid sites for glycoprotein detection under neutral pH.

Glycoproteins play vital roles in living organisms and often serve as biomarkers for some disease. However, due to the low content of glycoprotein in biological fluids, selective detection of glycoproteins is still a challenging issue that needs to be addressed. In this study, molecularly imprinted colloidal array with multi-boronic acid sites for glycoprotein detection under physiological pH was proposed. Monodispersed glycoprotein imprinted particles (SiO2@PEI/MIPs) was first prepared based on surface imprinting strategy using horseradish peroxidase (HRP) as template, and polyethyleneimine (PEI) was used to increase the number of boronic acid groups. The binding experiment indicated that the SiO2@PEI/MIPs hold satisfactory adsorption capacity (1.41 µmol/g), rapid adsorption rate (40 min) and preferable selectivity toward HRP. Then the SiO2@PEI/MIPs was assembled into close-packed colloidal array to construct a label free optical sensor (denoted as GICA). Benefiting from the high ordered photonic crystal structure, binding of HRP onto the GICA could be directly readout from the changes in structure color and diffracted wavelength. The structure color of the GICA changed from bright blue to yellow with the diffraction wavelength red shifted 59 nm when the HRP concentration increased from 2.5 to 15 µmol/L. Importantly, the GICA was capable of detecting HRP from human serum samples. All those results indicated the potential of the GICA for naked-eye detection of glycoprotein.

Biomass activated carbon-derived imprinted polymer with multi-boronic acid sites for selective capture of glycoprotein.

Glycoproteins play crucial roles in many biological events such as protein folding, information transmission, nerve conduction, and molecular recognition. Some glycoproteins serve as disease biomarkers in clinical settings. However, selective detection of glycoprotein often faces great challenges, owing to its low abundance in complex biological samples. In this case, develop a highly sensitive and selective approach for glycoprotein detection is urgently needed. Molecularly imprinted polymers (MIPs) have proved to be an ideal absorbent material in detection and separation science. Herein, a novel biomass activated carbon-derived imprinted polymer (BAC@PEI/PBA/MIPs) was fabricated for selective recognition of glycoprotein. The as-prepared BAC@PEI/PBA/MIPs was synthesized using waste tea derived carbon as matrix, albumin chicken egg (OVA) as template, and dopamine as functional monomer. Branched polyethyleneimine (PEI) was covalently bonded on the BAC surface to increase the number of boronic acid moieties. Benefiting from the self-polymerization of dopamine and multi-boronic acid sites, a great number of recognition sites were presented under mild conditions. The static adsorption experiment showed that the BAC@PEI/PBA/MIPs exhibited a high binding capacity of 196.2 mg/g, rapid adsorption dynamics of 40 min, excellent selectivity and satisfactory reusability for OVA. Furthermore, the practicability of BAC@PEI/PBA/MIPs was verified by isolation of OVA from egg white. The good binding performance and facile preparation process make BAC@PEI/PBA/MIPs attractive for glycoprotein recognition, indicating its potential applications in biomedical research and clinical diagnostics.

Walnut intake may increase circulating adiponectin and leptin levels but does not improve glycemic biomarkers: A systematic review and meta-analysis of randomized clinical trials.

BACKGROUND & OBJECTIVE: Walnut intake is considered a healthy dietary approach worldwide, particularly as a nutritional tool for the management of obesity and cardiometabolic disorders. Among these lines, leptin and adiponectin, as well as glycemic biomarkers, deserve further attention. We aimed to examine the impact of walnut intake on circulation levels of leptin and adiponectin through a systematic review and meta-analysis of randomized clinical trials (RCTs); secondarily, assessing the glycemic profile as well. METHODS: The literature search was implemented in four following databases: Web of Science, Scopus, PubMed/Medline, and Google Scholar, thus, determining studies that measured the effects of walnut consumption on adiponectin, leptin, and glycemic biomarkers levels from 2004 up to December 2019. RESULTS: Fourteen trials were include in the meta-analysis, with an intervention period ranging from 5 weeks to 12 months.Walnut intake increased leptin (weighted mean difference (WMD): 2.502 ng/mL; 95 % CI: 2.147-2.856, p < 0.001) and adiponectin (WMD: 0.440 ng/mL; 95 % CI: 0.323 to 0.557, p < 0.001) levels. Pertaining to glycemic biomarkers, neither overall analyses nor sub-analyses corroborated with changes in fasting blood glucose (WMD: 0.500 mg/dL, 95 % CI: -0.596, 1.596, p = 0.371), insulin (WMD: -0.21 mg/dL, 95 % CI: -0.67, 0.24, p = 0.367), and glycated hemoglobin (WMD: 0.004 mg/dL, 95 % CI: -0.041, 0.049, p = 0.870) concentrations. CONCLUSION: Walnut intake may increase leptin and adiponectin levels but does not improve glycemic biomarkers.

The environmental friendliness of fuzzy-ball drilling fluids during their entire life-cycles for fragile ecosystems in coalbed methane well plants.

To protect the vulnerable ecosystems in coalbed methane(CBM) well plants from the pollution of drilling fluids, the environmental friendliness of fuzzy-ball drilling fluids was evaluated. Further, the combination of solidification and in-situ landfill were proposed to optimize their waste disposal. Firstly, the samples for tests were collected from the well plants. Then, their environment-related properties were evaluated with the indicator vector from wastewater perspective to monitor their environmental friendliness. Lastly, comparative analysis of two wells in Linfen, China was conducted concerning engineering and economic parameters. Results showed that these indicators of the new fuzzy-ball drilling fluids and their raw materials were within the ceiling limits of related national standard, whereas those of waste fuzzy-ball drilling fluids exceeded the limits. The mechanical strengths of the waste drilling fluids solidified directly could meet the practical transport demand, and their leachates met the standardized requirements due to the strong biodegradability of fuzzy-ball fluids. Field studies demonstrated the economic effectiveness of fuzzy-ball drilling fluids, reconciling the conflict between environment-protecting and cost-reducing. In conclusion, fuzzy-ball drilling fluids are feasible for fragile ecosystem protection in CBM well plants. The environmental friendliness relies on their material, structural and functional basis.