Amelioration of adsorptive efficacy by synergistic assemblage of functionalized graphene oxide with esterified cellulose nanofibers for mitigation of pharmaceutical waste.

An effort has been undertaken for valorization of surplus biomass to synthesize sustainable and commercially competitive nanoadsorbents utilizing green synthetic strategies. This study encompasses a pioneering research on the comparative adsorption analysis of different modified forms of graphene oxide (GO) combined with functionalized cellulose nanofibers (CNF) derived from surplus biomass for elimination of noxious drug species from aqueous environment with a comprehensive study for evaluating the effect of loading percentage of functionalized GO. Characteristic assessments of the prepared nanocomposites were performed using FT-IR studies, powder XRD studies, FESEM analysis, EDS analysis and BET studies. The prepared nanohybrids were evaluated for their adsorptive performance for elimination of ciprofloxacin and ofloxacin and their performance was optimized in terms of adsorbent loading, pH and initial drug concentration. Further, investigation of adsorbent properties and the adsorption process was undertaken by studying different kinetic and isotherm models of adsorption. The adsorption potential of functionalized CNF was substantially ameliorated through its facile assemblage with functionalized GO. The experimental outcomes revealed that 20 wt% loading of carboxylated graphene oxide within the perforated surface of esterified cellulose nanofibres exhibited best adsorption performance with maximum removal capacity of 45.04 mg g-1 and 85.30 mg g-1 for ciprofloxacin and ofloxacin, respectively. The outstanding regenerability and reusability of nanocomposites present tremendous potential for development of inexpensive and sustainable sorbent materials for managing pharmaceutical pollution. Literature presents scarce data and insufficient number of reports which thoroughly compares the role of differently functionalized GO to potentiate the adsorptive performance of biomass based nanocellulose and its broad application prospects in wastewater remediation. This marks the novelty of the present investigation.

Prosthetic rehabilitation of a young patient with Hypophosphatasia - A review and case report.

Hypophosphatasia is a congenital disease characterized by deficiency of serum and tissue non-specific alkaline phosphatase activity. The disease occurs due to mutations in the liver/bone/kidney alkaline phosphatase gene. Six clinical forms of hypophosphatasia are recognized. Systemic symptoms of the disease are respiratory complications, premature craniosynostosis, widespread demineralization and rachitic changes in the metaphases, stress fractures, chondrocalcinosis and osteoarthropathy. Characteristic dental symptoms include premature loss of deciduous teeth, premature exfoliation of fully rooted permanent teeth, severe dental caries and alveolar bone loss. This clinical report describes the prosthetic rehabilitation of a sixteen year old female patient with hypophosphatasia with partial anodontia and no occlusion. Patient was managed clinically by saving her remaining teeth, fabricating a maxillary overdenture and mandibular cast partial denture. This not only helped her functionally in biting and chewing food and achieving a good occlusion, but also restored her confidence and self image by improving the aesthetics.