Correlation of hot spot to breast separation in patients treated with postlumpectomy tangent 3D-CRT using field-in-field technique and mixed photon energies.

Radiotherapy to an intact breast was previously determined to have a positive correlation between breast separation measurement and hot spot dose. As breast separation measurement increased, hot spot dose increased. The purpose of this retrospective study was to determine if this correlation persisted despite current techniques including field-in-field (FiF) blocking and mixed photon energies. Radiation treatment plans on unilateral intact breasts from 90 female, early stage breast cancer patients treated with lumpectomy were analyzed. Plans were created using 3-dimensional conformal radiation therapy (3D-CRT) nondivergent opposing tangent beams, FiF technique, and 6 MV with or without higher energy photons. Data collected included breast separation measurement, hot spot point dose and location, number of beams, photon energy, clinical target volume (CTV) coverage and breast volume coverage. Correlations between breast separation measurement and each of these values were determined. The positive correlation between breast separation measurement and hot spot dose persisted despite incorporating FiF and mixed photon energies. Correlations were also found between breast separation and the number of beams as well as breast separation and photon energy. Larger breast separations tended to be treated with additional beams of higher photon energy. There were no correlations found between breast separation and CTV or breast volume coverage. The data in this study suggested the medical dosimetrist should expect hot spots above prescription dose of 106%, 107%, and 108% for small, medium and large breast separation sizes respectively. Additionally, adding a high energy photon bean may be indicated with medium and large breast separations.

Retrospective survey of owners' experiences with palliative radiation therapy for pets.

OBJECTIVE To describe animal owners' experiences with palliative radiation therapy (PRT) of pets and identify factors influencing satisfaction with their pets' treatment. DESIGN Retrospective, cross-sectional study. SAMPLE 118 owners of dogs, cats, or rabbits. PROCEDURES Medical records were searched to identify animals that underwent PRT between 2004 and 2013. Signalment, tumor-related data, and outcome information were recorded. Owners completed an electronic survey assessing satisfaction with treatment (ie, satisfaction with the decision for their pet to undergo PRT and indication that they would choose PRT for their pet again), expectations regarding PRT, and perceptions of their pets' quality of life (QOL) and signs of discomfort from acute adverse radiation effects. Additional data regarding practical aspects of treatment, pet death, communications with veterinarians, and owner demographics were collected. Variables were tested for association with measures of owner satisfaction. RESULTS 92 of 116 (79%) owners were satisfied with the decision to have their pets undergo PRT. Most (92/118 [78%]) owners reported their pet's QOL improved after PRT; these owners were significantly more likely to be satisfied than those who did not report improved QOL. Owners who perceived their pets had discomfort from adverse radiation effects (38/116 [33%]) were significantly less likely to be satisfied than owners who did not report this observation. Measures of satisfaction were not associated with patient survival time. Twenty-one of 118 (18%) owners indicated they expected PRT would cure their pet's tumor. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that short life expectancy should not deter recommendation of PRT for pets. Protocols that minimize risk of acute adverse effects may be advantageous. Veterinarians should attempt to ensure that owners understand the goals of PRT.