1.
Bioorg Med Chem Lett
; 77: 129005, 2022 12 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36174834
RESUMO
Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candidate molecules.
Assuntos
Receptores Adrenérgicos alfa 2
2.
Bioorg Med Chem Lett
; 69: 128783, 2022 08 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35569686
RESUMO
In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.