Blind Source Separation of Intermittent Frequency Hopping Sources over LOS and NLOS Channels.

This paper studies blind source separation (BSS) for frequency hopping (FH) sources. These radio frequency (RF) signals are observed by a uniform linear array (ULA) over (i) line-of-sight (LOS), (ii) single-cluster, and (iii) multiple-cluster Spatial Channel Model (SCM) settings. The sources are stationary, spatially sparse, and their activity is intermittent and assumed to follow a hidden Markov model (HMM). BSS is achieved by leveraging direction of arrival (DOA) information through an FH estimation stage, a DOA estimation stage, and a pairing stage with the latter associating FH patterns with physical sources via their estimated DOAs. Current methods in the literature do not perform the association of multiple frequency hops to the sources they are transmitted from. We bridge this gap by pairing the FH estimates with DOA estimates and labeling signals to their sources, irrespective of their hopped frequencies. A state filtering technique, referred to as hidden state filtering (HSF), is developed to refine DOA estimates for sources that follow a HMM. Numerical results demonstrate that the proposed approach is capable of separating multiple intermittent FH sources.

Plasma Glucosylsphingosine in GBA1 Mutation Carriers with and without Parkinson's Disease.

BACKGROUND: Biallelic mutations in the GBA1 gene encoding glucocerebrosidase cause Gaucher's disease, whereas heterozygous carriers are at risk for Parkinson's disease (PD). Glucosylsphingosine is a clinically meaningful biomarker of Gaucher's disease but could not be assayed previously in heterozygous GBA1 carriers. OBJECTIVE: The aim of this study was to assess plasma glucosylsphingosine levels in GBA1 N370S carriers with and without PD. METHODS: Glucosylsphingosine, glucosylceramide, and four other lipids were quantified in plasma from N370S heterozygotes with (n = 20) or without (n = 20) PD, healthy controls (n = 20), idiopathic PD (n = 20), and four N370S homozygotes (positive controls; Gaucher's/PD) using quantitative ultra-performance liquid chromatography tandem mass spectrometry. RESULTS: Plasma glucosylsphingosine was significantly higher in N370S heterozygotes compared with noncarriers, independent of disease status. As expected, Gaucher's/PD cases showed increases in both glucocerebrosidase substrates, glucosylsphingosine and glucosylceramide. CONCLUSIONS: Plasma glucosylsphingosine accumulation in N370S heterozygotes shown in this study opens up its future assessment as a clinically meaningful biomarker of GBA1-PD. © 2021 International Parkinson and Movement Disorder Society.