Disentangling nature from nurture in examining the interplay between parent-child relationships, ADHD, and early academic attainment.

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is highly heritable and is associated with lower educational attainment. ADHD is linked to family adversity, including hostile parenting. Questions remain regarding the role of genetic and environmental factors underlying processes through which ADHD symptoms develop and influence academic attainment. METHOD: This study employed a parent-offspring adoption design (N = 345) to examine the interplay between genetic susceptibility to child attention problems (birth mother ADHD symptoms) and adoptive parent (mother and father) hostility on child lower academic outcomes, via child ADHD symptoms. Questionnaires assessed birth mother ADHD symptoms, adoptive parent (mother and father) hostility to child, early child impulsivity/activation, and child ADHD symptoms. The Woodcock-Johnson test was used to examine child reading and math aptitude. RESULTS: Building on a previous study (Harold et al., 2013, Journal of Child Psychology and Psychiatry, 54(10), 1038-1046), heritable influences were found: birth mother ADHD symptoms predicted child impulsivity/activation. In turn, child impulsivity/activation (4.5 years) evoked maternal and paternal hostility, which was associated with children's ADHD continuity (6 years). Both maternal and paternal hostility (4.5 years) contributed to impairments in math but not reading (7 years), via impacts on ADHD symptoms (6 years). CONCLUSION: Findings highlight the importance of early child behavior dysregulation evoking parent hostility in both mothers and fathers, with maternal and paternal hostility contributing to the continuation of ADHD symptoms and lower levels of later math ability. Early interventions may be important for the promotion of child math skills in those with ADHD symptoms, especially where children have high levels of early behavior dysregulation.

Utilising Genetically-Informed Research Designs to Better Understand Family Processes and Child Development: Implications for Adoption and Foster Care Focused Interventions.

Understanding the interplay between genetic factors and family environmental processes (e.g., inter-parental relationship quality, positive versus negative parenting practices) and children's mental health (e.g., anxiety, depression, conduct problems, ADHD) in the contexts of adoption and foster-care research and practice is critical for effective prevention and intervention programme development. Whilst evidence highlights the importance of family environmental processes for the mental health and well-being of children in adoption and foster care, there is relatively limited evidence of effective interventions specifically for these families. Additionally, family-based interventions not specific to the context of adoption and foster-care typically show small to medium effects, and even where interventions are efficacious, not all children benefit. One explanation for why interventions may not work well for some is that responses to intervention may be influenced by an individual's genetic make-up. This paper summarises how genetically-informed research designs can help disentangle genetic from environmental processes underlying psychopathology outcomes for children, and how this evidence can provide improved insights into the development of more effective preventative intervention targets for adoption and foster-care families. We discuss current difficulties in translating behavioural genetics research to prevention science, and provide recommendations to bridge the gap between behavioural genetics research and prevention science, with lessons for adoption and foster-care research and practice.

Familial transmission of depression and antisocial behavior symptoms: disentangling the contribution of inherited and environmental factors and testing the mediating role of parenting.

BACKGROUND: Genetic and environmental influences on child psychopathology have been studied extensively through twin and adoption designs. We offer a novel methodology to examine genetic and environmental influences on the intergenerational transmission of psychopathology using a sample of parents and children conceived through in vitro fertilization (IVF). METHOD: The sample included families with children born through IVF methods, who varied as to whether the child was genetically related or unrelated to the rearing mother and father (mother genetically related, n=434; mother genetically unrelated, n=127; father genetically related, n=403; father genetically unrelated, n=156). Using standardized questionnaires, mothers and fathers respectively reported on their own psychopathology (depression, aggression), their parenting behavior toward their child (warmth, hostility) and their child's psychopathology (depression, aggression). A cross-rater approach was used, where opposite parents reported on child symptoms (i.e. fathers reported on symptoms for the mother-child dyad, and vice versa). RESULTS: For mother-child dyads, a direct association between mother depression and child depression was observed among genetically unrelated dyads, whereas a fully mediated path was observed among genetically related dyads through mother-to-child hostility and warmth. For father-child dyads, direct and mediated pathways were observed for genetically related father-child dyads. For aggression, the direct association between parent aggression and child aggression was fully mediated by parent-to-child hostility for both groups, indicating the role of parent-to-child hostility as a risk mechanism for transmission. CONCLUSIONS: A differential pattern of genetic and environmental mediation underlying the intergenerational transmission of psychopathology was observed among genetically related and genetically unrelated father-child and mother-child dyads.

The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences.

BACKGROUND: Exposure to prenatal stress is associated with later adverse health and adjustment outcomes. This is generally presumed to arise through early environmentally mediated programming effects on the foetus. However, associations could arise through factors that influence mothers' characteristics and behaviour during pregnancy which are inherited by offspring. METHOD: A 'prenatal cross-fostering' design where pregnant mothers are related or unrelated to their child as a result of in vitro fertilization (IVF) was used to disentangle maternally inherited and environmental influences. If links between prenatal stress and offspring outcome are environmental, association should be observed in unrelated as well as related mother-child pairs. Offspring birth weight and gestational age as well as mental health were the outcomes assessed. RESULTS: Associations between prenatal stress and offspring birth weight, gestational age and antisocial behaviour were seen in both related and unrelated mother-offspring pairs, consistent with there being environmental links. The association between prenatal stress and offspring anxiety in related and unrelated groups appeared to be due to current maternal anxiety/depression rather than prenatal stress. In contrast, the link between prenatal stress and offspring attention deficit hyperactivity disorder was only present in related mother-offspring pairs and therefore was attributable to inherited factors. CONCLUSIONS: Genetically informative designs can be helpful in testing whether inherited factors contribute to the association between environmental risk factors and health outcomes. These results suggest that associations between prenatal stress and offspring outcomes could arise from inherited factors and post-natal environmental factors in addition to causal prenatal risk effects.

The longitudinal association between attributions and marital satisfaction: direction of effects and role of efficacy expectations.

This study investigated the direction of possible causal effects between attributions for negative partner behavior and marital satisfaction and tested whether any effects are mediated by efficacy expectations regarding marital conflict. Couples married for 15-20 months completed measures of attribution and satisfaction at Time 1 and at Time 3 (18 months later). At Time 2 (6 months after Time 1) they completed a measure of efficacy expectations. For both husbands and wives, a cross-lagged effects model showed that the paths from causal attributions to later satisfaction and from satisfaction to later causal attributions were significant. Efficacy expectations mediated the temporal relation between attributions and satisfaction. These findings support the assumption that there is a reciprocal causal influence between attributions and satisfaction but suggest important modifications to models of close relationships and marital therapy.

Marital conflict and adolescent distress: the role of adolescent awareness.

The present longitudinal study (1989-1991) of seventh-grade adolescents (173 boys, 197 girls; M age = 12.7 in 1989) living in the rural Midwest examined the influence of children's awareness of marital conflict and reported level of parental hostility on symptoms of adolescent distress. The theoretical model guiding the research indirectly linked marital conflict to adolescent perceptions of parents' hostility through the mediating effects of parents' and observers' report of hostility toward the adolescent and through adolescent awareness of the frequency of interparental conflict. Controlling for earlier levels of psychological distress, we hypothesized a direct path between adolescent report of parent hostility and adolescent maladjustment. Maximum likelihood estimation of the proposed model showed that marital conflict was significantly related to parents' and observers' reports of parent hostility toward the adolescent and to adolescent awareness of conflict frequency. Both parent hostility and adolescent awareness of the frequency of marital conflicts were significantly related to adolescent perceptions of parent hostility. When controlled for earlier distress, adolescent report of parent hostility significantly predicted the later internalizing and externalizing symptoms of these teenagers. The model predicted externalizing problems for boys but not girls. Otherwise, there were no gender differences in the postulated causal processes.

Mom and dad are at it again: adolescent perceptions of marital conflict and adolescent psychological distress.

In these two studies, the authors used children's perceptions of family relationships to examine simultaneously direct and indirect links between marital conflict and child adjustment. With data pertaining to 146 sixth and seventh graders, Study 1 supported direct and indirect effects of perceptions of marital conflict on internalizing behaviors, and indirect effects for externalizing behaviors. In Study 2, data analyzed from 451 families showed indirect effects of marital conflict and parent-to-child hostility, through adolescent perceptions of such behavior, on both current distress and distress 12 months later in 3 of 4 models estimated. Direct and indirect effects were found for boys' concurrent internalizing behavior. Implications and limitations of both studies are discussed to address the need for a more sophisticated theoretical approach to examine why an association exists between marital conflict and child adjustment.