[Sonographic diagnostics in neurological emergency and intensive care medicine]. / Sonographische Diagnostik in der neurologischen Notfall- und Intensivmedizin.

BACKGROUND: This article gives an up-to-date overview of neurosonographic emergency and intensive care diagnostics. METHODS: Selective literature research from 1984 with critical appraisal and including national and international guidelines. RESULTS: Fast and valid diagnostics in acute stroke is the main field of application of neurosonography. Specific monitoring methods bear great advantages for intensive care patients, especially "as-often-as-wanted" repetitive imaging under real-time conditions. A number of new developments make neurosonography an interesting area of research. CONCLUSIONS: Neurosonography has played a key role in neurological emergency and intensive care medicine for many years. It remains important to continuously support dissemination of the method.

The potential of neurosonography in neurological emergency and intensive care medicine: monitoring of increased intracranial pressure, brain death diagnostics, and cerebral autoregulation­ part 2.

Transcranial B-mode sonography is an easy to use bedside imaging modality to monitor significant changes of the brain parenchyma such as in malignant middle cerebral infarction or intracerebral hemorrhage. The elevation of intracranial pressure can be followed with various neurosonographical techniques: Measurements of the ventricular width, midline shift, arterial resistance, and optic nerve sheath diameter. They should be viewed as complementary to each other and to other imaging modalities. Repeated cCT and MRI may be avoided in unstable patients by bedside neurosonography in the hands of an experienced physician. Monitoring of evolving hydrocephalus using serial measurements of the third and lateral ventricles can be used to guide therapeutic decisions such as the removal of a ventricular drainage. The cessation of cerebral blood flow in the case of intracranial pressure exceeding systemic arterial pressure is an important part of brain death diagnostics. Early demonstration of a sufficient temporal bone window is needed in patients in whom brain death may be expected. Cerebrovascular autoregulation is an integer component of the brain's blood supply and is compromised in a variety of neurological diseases. In neurological/neurosurgical patients in the intensive care unit, its assessment allows for extended neuromonitoring and control of therapeutic procedures.

Brain tumor imaging with transcranial sonography: state of the art and review of the literature.

Transcranial sonography (TCS) is a widely used non-invasive bedside method to evaluate the brain, its vessels, perfusion and pathologies. Transcranial brain tumor sonography emerged in the early nineties and while B-mode imaging and Color-Doppler have acquired widespread use, especially for intraoperative imaging, other ultrasound modalities such as Perfusion Imaging are applied more in the research field. The aim of this review is to give an overview of the different ultrasound modalities and their respective application in sonographic brain tumor imaging.

Transcranial perfusion sonography using a low mechanical index and pulse inversion harmonic imaging: reliability, inter-/intraobserver variability.

PURPOSE: Transcranial perfusion sonography (TPS) is an emerging noninvasive bedside method for evaluating brain perfusion. The purpose was to assess the feasibility of a low MI/almost real-time frame rate approach and to test its intra-/interobserver variability. MATERIALS AND METHODS: 10 healthy volunteers were investigated 3 times with TPS at a low MI (1.0) and a high frame rate (8.3 Hz). Investigations were performed by 2 sonographers in a cross-over design: 1.) twofold measurements each with 5 volunteers (intraobserver test), and 2.) single measurements of the other 5 volunteers (interobserver test). From 8 established regions of interest (ROI), time-intensity curves (TIC) with the following parameters were calculated: peak intensity (PI), time-to-PI (TTP), area-under-curve (AUC), and cerebral transit time (CTT). The TIC quality was described by the coefficient of determination. TIC parameters were presented descriptively. Intra- and interobserver variability was tested by Spearman's correlation. RESULTS: The overall quality of the TIC was very good (mean r(2) = 0.92, 0.87 - 0.97). TTP (25.7 - 28.1 sec; mean 26.8 sec) and CTT (8.2 - 10.7 sec; mean 9.9 sec) were the most robust parameters. The intraobserver variability was lower with the more experienced sonographer (r = 0.70 vs. r = 0.29). The interobserver reliability was r = 0.34 (p < 0.05). CONCLUSION: Low MI TPS allows for nearly real-time imaging facilitating probe control. Sound sonographer experience allows for a high reliability and makes TPS an interesting tool for the diagnosis and follow-up of perfusion changes, e. g. in stroke or anti-angiogenic brain tumor therapy.

Comparison of perfusion harmonic imaging and perfusion mr imaging for the assessment of microvascular characteristics in brain tumors.

PURPOSE: The purpose of this study was to evaluate the potential of perfusion harmonic imaging (pHI) for assessing microvascular characteristics of brain tumors and to compare this ultrasound technique to perfusion MRI (pMRI). MATERIALS AND METHODS: Twenty-five patients with brain tumors underwent transtemporal pHI and fourteen of these patients underwent additional pMRI. Time-intensity curves of two different regions of interest (ROIs; (1) enhancing tumor; (2) healthy brain) were calculated off-line, and the following parameters were compared between the two ROIs and the two methodologies: time-to-peak intensity (TTP [sec]), the ratios of the peak intensities (PI ratio), the ratios of the positive slope gradient (PG ratio) and the ratios of the area under the curve (AUC ratio). p < 0.05 was considered statistically significant. RESULTS: Four of 25 patients were excluded due to bone window insufficiency or unfavorable tumor location. Focal abnormal echogenicity was detected in native B-mode in 86 % of the patients. Contrast agent administration led to remarkable echo enhancement in the tumor in all patients with corresponding time-intensity curves. Both pHI and pMRI showed significant differences with respect to the mean PI, PG and AUC (pHI: p < 0.001 / < 0.001 / < 0.001; pMRI: p < 0.05 / < 0.05 / < 0.001) when comparing tumor to healthy brain. The TTP was not significantly different in tumor and brain tissue. Comparison of pHI and pMRI data did not show any significant differences for three of four parameter ratios between both methodologies. CONCLUSION: PHI provides a new technique for assessing microvascular characteristics of brain tumors reflecting their abnormal perfusion. Overall comparison of this methodology to pMRI demonstrated encouraging results. Further studies should address the clinical potential of pHI especially in view of microvascular response to anti-angiogenic treatment.

Transcranial ultrasound perfusion imaging: implementation of a low MI and a high frame rate.

PURPOSE: Conventional transcranial ultrasound perfusion imaging (UPI) depends on bolus injection and is limited to triggered imaging. To improve our set-ups, we compared two imaging modalities with two different frame rates (FR) and mechanical indices (MI), intending to approach conditions more similar to real time imaging in order to increase parameter precision. MATERIALS AND METHODS: Fifteen healthy volunteers were investigated twice with UPI after i. v. administration of 1 ml of SonoVue(R): first, with a high MI (1.6) and a low FR (0.67 Hz)) and second, with a low MI (1.0) and a high FR (5 Hz). Apart from visual analysis, time-intensity curves were calculated from three regions of interest (ROI) and peak intensity (PI), time to PI (TP), and area-under-the-curve (AUC) were compared between the two imaging modalities. RESULTS: Visually, only scarce contrast enhancement was observed in 10/15 probands, and penetration depth was markedly lower at the low MI/high FR setting, while the high MI/low FR setting lead to very intense enhancement in 13/15 individuals. Signal-to-noise-ratio was higher at the low MI/high FR setting. TP was not significantly different between the two set-ups (p > 0.05). PI and AUC were significantly lower at the low MI/high FR setting (p

Intimal flap in a common carotid artery in a patient with Marfan's syndrome.

Dissection of the common carotid artery is a rare but important complication of Marfan's syndrome. The following case describes a patient with formation of an intimal flap of the common carotid artery who had suffered from an aortic dissection years before.

Stroke recurrence and its prevention in patients with patent foramen ovale.

BACKGROUND: It is unclear whether medical or invasive (surgical or catheter interventional) treatment is preferable to prevent recurrence of cerebral ischemia in patients with patent foramen ovale (PFO) as the suspected cause of stroke and what the role of concomitant risk factors is in stroke recurrence. METHODS: Over a period of ten years, 124 patients (mean age 51 +/- 15 years) with cryptogenic cerebral ischemia and PFO were included into the study and prospectively followed over a mean of 52 +/- 32 months. Of these, 83 were treated medically, 34 underwent transcatheter closure, and seven had surgical closure of the foramen. Of the medically treated patients, 11 stopped medication during follow-up. Recurrent ischemic events and risk factors for recurrence were analyzed. RESULTS: Annual stroke recurrence rates were generally low and comparable in catheter and medically treated patients, and in patients who had stopped medication (2.9%/2.1%2.2%/year). Patients suffering from recurrence after transcatheter closure (n = 2) both had residual shunts. No stroke recurrence was observed in the few surgically treated patients. An atrial septal aneurysm was not a predictor of recurrent or multiple strokes (p > 0.05, OR = 0.31, and OR = 0.74). Large shunts and a history of previous ischemic events were considerably more frequent in patients with recurrent strokes (p < 0.05, OR = 5.0, and OR = 4.4). Pulmonary embolism and case fatality rates were significantly higher in patients with stroke recurrence (p < 0.001, and p < 0.01). CONCLUSIONS: The absolute risk of recurrent cerebrovascular events in patients with PFO receiving medical or catheter interventional therapy is low. The small group of untreated patients had a comparably low rate of stroke recurrences. Previous ischemic events and shunt size were risk factors in this observational study. Given conflicting findings across multiple studies, enrollment into a randomized controlled trial would be the optimal choice.

[Cerebral perfusion sonography in comparison with perfusion MRT: a study with healthy volunteers]. / Zerebrale Perfusionssonographie im Vergleich zur Perfusions-MRT: Eine Normalprobandenstudie.

AIM: Perfusion harmonic imaging (PHI) has been used for several years now in neurological as well as other patients. The aim of the study was to compare PHI with perfusion-weighted MR tomography (pMRT) for the evaluation of cerebral parenchymal perfusion. Furthermore, the influence of different trigger intervals on the contrast kinetics in PHI was analysed. METHOD: Fifteen healthy individuals were evaluated with two transtemporal PHI investigations and one pMRT. In PHI, 62 time-triggered images at two different trigger intervals (1 and 0.4 Hz) were recorded after an intravenous bolus of 2 ml of SonoVue(R). pMRT was carried out according to a standard technique using 0.2 mmol/kg Gadolinium-DTPA (Magnevist) and T2*-weighted EPI-sequences. Time-intensity curves of PHI and pMRT-determined data including peak intensity (PI), time-to-peak-intensity (TTP [s]), and area-under-the-curve (AUC) were calculated off-line from 4 regions of interest: ipsi- and contralateral thalamus (i-TH, k-TH), lentiform nucleus (NUC), and white matter (ML). These parameters were compared between the data sets of the two different trigger intervals. Additionally, ratios of the above parameters were calculated to compare the two methods (TH/NUC and TH/ML). RESULTS: Comparison of the two trigger intervals showed significantly lower AUC-values at the higher trigger interval, while the trigger interval had no significant impact on PI- and TTP- values. A good correlation was seen between the trigger intervals for AUC-values and, to a lesser extent, for PI-values. TTP-values did not correlate. TTP was the only depth-independent parameter. There was no significant difference between PHI and pMRT in 10 of 12 parameter ratios analysed. Merely the PI-ratio of i-TH/ML was significantly different at both trigger intervals. CONCLUSION: Regarding the development of adequate set-ups for transcranial PHI, further parameters with impact on contrast agent kinetics (MI, dose of contrast agent) have to be taken into account in addition to the trigger interval. Our findings suggest that, within certain limits, PHI is an imaging technique representing a valuable alternative to MR perfusion imaging, with the TTP representing the most reliable parameter. The AUC is useful for semi-quantitative evaluation of brain perfusion.

Second harmonic imaging: a new ultrasound technique to assess human brain tumour perfusion.

BACKGROUND: Second harmonic imaging is a new ultrasound technique that allows evaluation of brain tissue perfusion after application of an ultrasound contrast agent. OBJECTIVE: To evaluate the potential of this technique for the assessment of abnormal echo contrast characteristics of different brain tumours. METHODS: 27 patients with brain tumours were studied. These were divided into four groups: gliomas, WHO grade III-IV (n = 6); meningiomas (n = 9); metastases (n = 5); and others (n = 7). Patients were examined by second harmonic imaging in a transverse axial insonation plane using the transtemporal approach. Following intravenous administration of 4 g (400 mg/ml) of a galactose based echo contrast agent, 62 time triggered images (one image per 2.5 seconds) were recorded and analysed off-line. Time-intensity curves of two regions of interest (tumour tissue and healthy brain tissue), including peak intensity (PI) (dB), time to peak intensity (TP) (s), and positive gradient (PG) (dB/s), as well as ratios of the peak intensities of the two regions of interest, were derived from the data and compared intraindividually and interindividually. RESULTS: After administration of the contrast agent a marked enhancement of echo contrast was visible in the tumour tissue in all patients. Mean PI and PG were significantly higher in tumour tissue than in healthy brain parenchyma (11.8 v 5.1 dB and 0.69 v 0.16 dB/s; p < 0.001). TP did not differ significantly (37.1 v 50.2 s; p = 0.14). A tendency towards higher PI and PG as well as shorter TP was apparent in malignant gliomas. When comparing different tumour types, however, none of these variables reached significance, nor were there significant differences between malignant and benign tumours in general. CONCLUSIONS: Second harmonic imaging not only allows identification of brain tumours, but may also help in distinguishing between different tumour types. It gives additional and alternative information about tumour perfusion. Further studies are needed to evaluate the clinical potential of this technique in investigating brain tumours-for example in follow up investigations of patients undergoing radiation or chemotherapy-especially in comparison with neuroradiological and neuropathological findings.