RESUMO
BACKGROUND: Photodynamic therapy (PDT) has been explored for the treatment of recalcitrant viral warts (VW) with good results in recent publications. METHODS: We carried out a descriptive and observational study in 19 patients with recalcitrant VW. Methyl aminolaevulinic acid (MAL) was occluded for 3 hours and pulsed dye laser (PDL) was used as the light source. VW were treated weekly until they were clear or for a maximum of six sessions. RESULTS: A total of 53% of the VW cleared, and 26% of the patients demonstrated complete clearance of all their VW. The treatment was well tolerated and no adverse events were recorded. CONCLUSIONS: PDL-PDT is an effective and well-tolerated treatment option for patients with recalcitrant VW. Though only half of patients show any improvement, responders are likely to show complete clearance of their warts.
Assuntos
Ácido Aminolevulínico/análogos & derivados , Lasers de Corante/uso terapêutico , Fotoquimioterapia , Fármacos Fotossensibilizantes/uso terapêutico , Verrugas/tratamento farmacológico , Ácido Aminolevulínico/uso terapêutico , Humanos , Verrugas/virologiaAssuntos
Toxinas Botulínicas Tipo A/uso terapêutico , Ceratodermia Palmar e Plantar/terapia , Fármacos Neuromusculares/uso terapêutico , Adulto , Cloreto de Alumínio , Compostos de Alumínio/uso terapêutico , Adstringentes/uso terapêutico , Cloretos/uso terapêutico , Feminino , Mãos , Humanos , Falha de TratamentoAssuntos
Leucemia Linfocítica Crônica de Células B/etiologia , Dermatopatias Papuloescamosas/complicações , Idoso , Biópsia , Diagnóstico Diferencial , Humanos , Imuno-Histoquímica , Leucemia Linfocítica Crônica de Células B/diagnóstico , Masculino , Dermatopatias Papuloescamosas/diagnóstico , Dermatopatias Papuloescamosas/terapiaRESUMO
Hailey-Hailey disease (HHD) is a rare genodermatosis that is often difficult to treat. This paper reports three patients with HHD treated with one session of photodynamic therapy (PDT) using topical methyl aminolevulinic acid applied under occlusion for 3 hours and red light at 37 J/cm2 for 7.5 minutes. Our results are not successful: all of the patients suffered discomfort during the 3-4 weeks following PDT and only one patient experienced clinical improvement. None of the patients would like to repeat the treatment. PDT is at an exploratory stage; further studies are necessary to determine whether PDT is useful in the treatment of HHD.