Successful management strategy for giant primary hepatic rhabdomyosarcoma in 15-year-old male: a case report.

Primary hepatic rhabdomyosarcoma is an exceedingly rare type of sarcomas. A 15-year-old boy was admitted to the hospital with abdominal pain. Serial investigation showed a giant heterogeneous mass, with a diameter of 15 cm, located in the right lobe of the liver (segment 4a, 4b, 5, 6, 7, 8), with clear margins, non-homogeneous density in computerized tomography and the Positron Emission Tomography Scan Multi Slice revealed a peripherally slightly metabolically active hepatic mass (205 × 134 × 208 mm). Histopathological examination and the Immunohistochemical showed embryonal rhabdomyosarcoma. The management strategy involved multiple cycles of ifosfamide and doxorubicin and monitoring the tumor size, until the tumor size was suitable for the surgery. The management of hepatic rhabdomyosarcoma is a surgical challenge due to the late onset of symptoms, a limited number of reported cases, and poor prognosis. Surgical excision is the treatment of choice for primary hepatic rhabdomyosarcoma and combination between chemotherapy, surgery showed good results.

Metal complexes of macrocyclic schiff-base ligand: preparation, characterisation, and biological activity.

A new macrocyclic multidentate Schiff-base ligand Na4L consisting of two submacrocyclic units (10,21-bis-iminomethyl-3,6,14,17-tricyclo[17.3.1.1]tetracosa-1(23),2,6,8,10,12(24),13,17,19,21,-decaene-23,24-disodium) and its tetranuclear metal complexes with Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) are reported. Na4L was prepared via a template approach, which is based on the condensation reaction of sodium 2,4,6-triformyl phenolate with ethylenediamine in mole ratios of 2 : 3. The tetranuclear macrocyclic-based complexes were prepared from the reaction of the corresponding metal chloride with the ligand. The mode of bonding and overall geometry of the compounds were determined through physicochemical and spectroscopic methods. These studies revealed tetrahedral geometries about Mn, Co, and Zn atoms. However, square planar geometries have been suggested for Ni(II) and Cu(II) complexes. Biological activity of the ligand and its metal complexes against Gram positive bacterial strain Staphylococcus aureus and Gram negative bacteria Escherichia coli revealed that the metal complexes become more potentially resistive to the microbial activities as compared to the free ligand. However, these metal complexes do not exhibit any effects on the activity of Pseudomonas aeruginosa bacteria. There is therefore no inhibition zone.

Clinical and radiological study of Iraqi multiple sclerosis patients with childhood onset.

OBJECTIVE: To study the clinical and radiological characteristics of multiple sclerosis (MS) with onset below 18 years. METHODS: This retrospective study was carried out at the MS Clinic in the Medical City Hospital in Baghdad, Iraq between March 2008 and March 2009. The records of the center were surveyed, and 77 patients with the onset of MS below 18 years were identified. Their clinical and radiological data were then analyzed. RESULTS: The female:male ratio was 1.6:1, and the mean age at onset was 14.95 years. Seven (9.1%) patients where children (age below 10 years), and 70 (90.9%) patients where adolescents (age 10-18 years) at onset. Seventy patients (90.9%) had an initial course of relapsing remitting MS, 9 (11.7% of the total) of them progressed to secondary progressive MS after a mean duration of 9.87+/-4.135 years. Seven patients had primary progressive MS as the initial course. The most common presenting symptom was optic neuritis (35.8%). Fifty-nine (76.6%) patients had monofocal presentation, and 18 (23.4%) had polyfocal presentation. Fifty-one (63%) patients had periventricular MRI lesions. The percentage of supratentorial lesions was higher than infratentorial lesions, children had a higher incidence of basal ganglionic lesions than adolescents (p=0.002), and males had a higher incidence of infratentorial lesion than females (p=0.033). CONCLUSION: Male patients have a higher incidence of infratentorial MRI lesions than female patients. Children had a higher incidence of MRI lesions in the basal ganglia than adolescents.