RESUMO
Ocular wavefront aberrations are used to describe retinal image formation in the study and modeling of foveal and peripheral visual functions and visual development. However, classical eye models generate aberration structures that generally do not resemble those of actual eyes, and simplifications such as rotationally symmetric and coaxial surfaces limit the usefulness of many modern eye models. Drawing on wide-field ocular wavefront aberrations measured previously by five laboratories, 28 emmetropic (-0.50 to +0.50 D) and 20 myopic (-1.50 to -4.50 D) individual optical eye models were reverse-engineered by optical design ray-tracing software. This involved an error function that manipulated 27 anatomical parameters, such as curvatures, asphericities, thicknesses, tilts, and translations-constrained within anatomical limits-to drive the output aberrations of each model to agree with the input (measured) aberrations. From those resultant anatomical parameters, three representative eye models were also defined: an ideal emmetropic eye with minimal aberrations (0.00 D), as well as a typical emmetropic eye (-0.02 D) and myopic eye (-2.75 D). The cohorts and individual models are presented and evaluated in terms of output aberrations and established population expectations, such as Seidel aberration theory and ocular chromatic aberrations. Presented applications of the models include the effect of dual focus contact lenses on peripheral optical quality, the comparison of ophthalmic correction modalities, and the projection of object space across the retina during accommodation.
Assuntos
Emetropia , Miopia , Humanos , Miopia/fisiopatologia , Emetropia/fisiologia , Refração Ocular/fisiologia , Modelos BiológicosRESUMO
PURPOSE: The goal was to use SyntEyes modelling to estimate the allowable alignment error of wavefront-guided rigid contact lens corrections for a range of normal and keratoconic eye aberration structures to keep objectively measured visual image quality at or above average levels of well-corrected normal eyes. Secondary purposes included determining the required radial order of correction, whether increased radial order of the corrections further constrained the allowable alignment error and how alignment constraints vary with keratoconus severity. METHODS: Building on previous work, 20 normal SyntEyes and 20 keratoconic SyntEyes were fitted with optimised wavefront-guided rigid contact lens corrections targeting between three and eight radial orders that drove visual image quality, as measured objectively by the visual Strehl ratio, to near 1 (best possible) over a 5-mm pupil for the aligned position. The resulting wavefront-guided contact lens was then allowed to translate up to ±1 mm in the x- and y-directions and rotate up ±15°. RESULTS: Allowable alignment error changed as a function of the magnitude of aberration structure to be corrected, which depends on keratoconus severity. This alignment error varied only slightly with the radial order of correction above the fourth radial order. To return the keratoconic SyntEyes to average levels of visual image quality depended on maximum anterior corneal curvature (Kmax). Acceptable tolerances for misalignment that returned keratoconic visual image quality to average normal levels varied between 0.29 and 0.63 mm for translation and approximately ±6.5° for rotation, depending on the magnitude of the aberration structure being corrected. CONCLUSIONS: Allowable alignment errors vary as a function of the aberration structure being corrected, the desired goal for visual image quality and as a function of keratoconus severity.
Assuntos
Lentes de Contato , Topografia da Córnea , Ceratocone , Acuidade Visual , Humanos , Ceratocone/fisiopatologia , Ceratocone/diagnóstico , Topografia da Córnea/métodos , Adulto , Feminino , Masculino , Acuidade Visual/fisiologia , Adulto Jovem , Aberrações de Frente de Onda da Córnea/fisiopatologia , Aberrações de Frente de Onda da Córnea/diagnóstico , Refração Ocular/fisiologia , Córnea/diagnóstico por imagem , Córnea/fisiopatologiaRESUMO
PURPOSE: To compare optical performance, visual performance, and patient-perceived quality of vision with: (1) spectacles determined using subjective refraction and (2) spectacles determined using an objective optimisation method based on wavefront aberration data for eyes with keratoconus. METHODS: Thirty-seven eyes (20 subjects) with keratoconus underwent both subjective refraction and uncorrected wavefront aberration measurement. Wavefront aberration data were used to objectively identify a sphero-cylindrical refraction that optimised the visual image quality metric visual Strehl ratio (VSX). The two refractions were assembled in trial frames and worn by the subject in a random order. High-contrast visual acuity (VA), letter contrast sensitivity (CS), and the patient's short-term subjective preference were recorded for each prescription. RESULTS: Median magnitude of the dioptric difference (a measure of similarity between the subjective and objective refractions) was 2.77 D (range = 0.21-20.44 D, first quartile = 1.02 D, third quartile = 4.36 D). Sixty-eight per cent of eyes had better VA with the objective refraction and 32% of eyes gained more than one line of VA. Monocularly, objective refraction was preferred 68% of the time when looking at a distant acuity chart and 76% of the time when viewing a real-world dynamic scene. CONCLUSIONS: Objective refraction based on visual image quality derived from wavefront aberration data can be valuable in the determination of monocular spectacle refractions for individuals with keratoconus.
Assuntos
Ceratocone , Humanos , Óculos , Ceratocone/diagnóstico , Ceratocone/terapia , Prescrições , Refração Ocular , Acuidade VisualRESUMO
Purpose: To provide a tool for calculating radial and tangential retinal magnifications as functions of field angle and retinal shape and to articulate patterns of magnification across the retina for monocular and binocular combinations of prolate-, oblate-, and spherical-shaped retinas. Methods: Formulae were derived to calculate radial and tangential retinal magnifications (mm/deg) from field angle (degrees), retinal asphericity (unitless conic constant), retinal vertex radius of curvature (mm), and nodal point position (mm). Monocular retinal magnifications were determined for eyes with prolate, spherical, and oblate retinas as functions of field angle. Bilateral differences in magnifications were examined for combinations of those eyes. Results: Retinal shape substantially affects magnification profiles even for eyes with the same axial length. Greatest magnification changes across a retina and between eyes, as well as greatest increase in radial-tangential differences (distortion), occur with prolate retinas. Binocular magnification differences were smallest for oblate retinas. Nodal points anterior to the vertex center of curvature and oblate asphericity both cause field-dependent reductions in magnification relative to the fovea (barrel distortion), whereas nodal points posterior to vertex center of curvature and prolate asphericity cause the opposite (pincushion distortion). Retinal magnification differences due to eye shape are much greater than aniseikonia thresholds and chromatic differences in magnification. A spreadsheet tool implements the magnification calculations. Conclusions: Local retinal magnifications as functions of field angle have substantial effects on objective applications (imaging retinal anatomy) and subjective experiences (aniseikonia) and quantify an ocular property that differs across eye shapes and refractive errors. Translational Relevance: Methods are provided to customize the calculation of radial and tangential magnifications across the retina for individual eyes, which will bolster the multifactorial study of the effects of foveal and peripheral optics across eye shapes and refractive errors.
Assuntos
Aniseiconia , Fosmet , Erros de Refração , Humanos , Rádio (Anatomia) , Retina/diagnóstico por imagem , Campos VisuaisRESUMO
PURPOSE: To investigate whether the movement of a rigid sphero-cylindrical contact lens has a greater impact on the visual image quality in highly aberrated eyes than in normal eyes. METHODS: For 20 normal and 20 keratoconic SyntEyes, a previously determined best sphero-cylindrical rigid lens was permitted to shift by up to ±1 mm from the line of sight and rotate up to ±15°. Each of the 52,111 lens locations sampled was ray-traced to determine the influence on the wavefront aberration. In turn, the logarithm of visual Strehl ratio (log10 [VSX]) was calculated for each aberration structure and was used to estimate the associated changes in logMAR visual acuity. Finally, contour surfaces of two-letter change in visual acuity were plotted in three-dimensional misalignment space, consisting of decentrations in the x and y directions and rotation, and volumes within these surfaces were calculated. RESULTS: The variations in image quality within the misalignment space were unique to each eye. A two-letter loss was generally reached with smaller misalignments in keratoconic eyes (10.5 ± 4.7° of rotation or 0.27 ± 0.13 mm of shift) than in normal eyes (13.4 ± 1.8° and 0.39 ± 0.15 mm, respectively) due to larger cylindrical errors. For keratoconic eyes, on average, 14.4 ± 14.9% of misalignment space saw VSX values above the lower normal VSX threshold, well below the values of normal eyes of 48.5 ± 18.5%. In some eyes, a specific combination of lens shift and lens rotation away from the line of sight leads to a simulated improvement in visual image quality. CONCLUSION: Variations in visual image quality due to the misalignment of rigid sphero-cylindrical contact lens corrections are larger for keratoconic eyes than for normal eyes. In some cases, a specific misalignment may improve visual image quality, which could be considered in the design of the next generation of rigid contact lenses.
Assuntos
Lentes de Contato , Ceratocone , Olho , Humanos , Ceratocone/diagnóstico , Ceratocone/terapia , Rotação , Acuidade VisualRESUMO
PURPOSE: Eyecare is evolving increasingly personalised corrections and increasingly personalised evaluations of corrections on-eye. This report describes individualising optical and neural components of the VSX (visual Strehl) metric and evaluates personalisation using two clinical applications. (1) Better understanding visual experience: While VSX tracks visual performance in typical eyes, non-individualised metrics underestimated visual performance in highly aberrated eyes - could this be understood by personalising metrics? (2) Metric-optimised objective spherocylindrical refractions in typical and atypical eyes have used neural weighting functions of typical eyes - will personalisation affect the outcome in clinical 0.25D steps? METHODS: Orientation-specific neural contrast sensitivity was measured in four typical myopic and astigmatic eyes and six eyes with keratoconus. Wavefront error was measured in all eyes while uncorrected and when the keratoconic eyes wore wavefront-guided scleral lenses. Total experiment duration was 24-28 h per subject. Two versions of VSX were calculated for each application: one weighted ocular optics with measured neural contrast sensitivity data from that eye, another weighted optics with a representative neural function of typical eyes. Wavefront-guided corrections were evaluated using the two metric values. Spherocylindrical corrections that optimised each metric were identified. RESULTS: Metric values for keratoconic eyes improved by a mean factor of 1.99 (~0.3 log units) when personalised. Applying this factor to a larger sample of eyes from a previous keratoconus study reconciled dissonances between the percentage of eyes reaching normative best-corrected metric levels and the percentages of eyes reaching normative levels of visual acuity and contrast sensitivity. Spherocylindrical corrections that optimised both versions of VSX were clinically equivalent (mean ± SD Euclidean dioptric difference 0.13 ± 0.18 D). CONCLUSIONS: Personalising visual image quality metrics is beneficial when actual metric values are used (evaluating ophthalmic corrections on-eye against norms) and when fine increments in visual quality are imparted (wavefront-guided corrections). However, partially individualised metrics appear adequate when metrics relatively rank spherocylindrical corrections in 0.25 D steps.
Assuntos
Benchmarking , Ceratocone , Sensibilidades de Contraste , Humanos , Ceratocone/diagnóstico , Refração Ocular , Testes Visuais , Acuidade VisualRESUMO
PURPOSE: To expand the SyntEyes keratoconus (KTC) model to assess the Visual Image Quality (VIQ) of sphero-cylindrical spectacle and rigid contact lens corrections as keratoconus progresses. METHODS: The previously published SyntEyes KTC eye model to determine best sphero-cylindrical spectacle and rigid contact lens correction in keratoconic eyes was expanded to include the natural progression of keratoconus, thus allowing the assessment of corrected VIQ with disease progression. RESULTS: As keratoconus progresses, the pattern of visual Strehl ratio (VSX) in correction space for spectacles alters from a typical hourglass into a shell pattern. The former would guide the subjective refraction towards the optimal correction while the latter is relatively insensitive to large dioptric steps. In 15 out of the 20 SyntEyes, the shell pattern eventually produces two foci on different sides of the correction space separated by a clinically significant dioptric difference with a similar, albeit lower VIQ. Wearing the best possible spectacle corrections provided an average gain of up to 3.5 lines of logMAR visual acuity compared to the uncorrected cases, which increased to 5.5 lines for the best rigid contact lens correction. Continuing to wear a spectacle correction as the disease progresses often leads to a VIQ that is almost as bad as the uncorrected case. Continuing to wear a rigid contact lens correction as the disease progresses maintains a relatively high level of VIQ, albeit in the low range for typically well-corrected normal eyes. CONCLUSIONS: The results reflect the clinical experience that subjective refraction is difficult in highly-aberrated keratoconic eyes, the benefit of spectacle correction is short lived and that rigid contact lenses provide better and more stable VIQ with disease progression. Other aspects, such as the presence and behaviour of the second focus in some cases, remain to be confirmed clinically.
Assuntos
Lentes de Contato , Ceratocone , Óculos , Humanos , Ceratocone/diagnóstico , Ceratocone/terapia , Refração Ocular , Acuidade VisualRESUMO
This work intends to determine the optimal refractive spectacle and scleral lens corrections for keratoconus patients using the visual Strehl (VSX) visual image quality metric and the SyntEyes models with the synthetic biometry of 20 normal eyes and 20 keratoconic eyes. These included the corneal tomography and intraocular biometry. A series of virtual spherocylindrical spectacle and scleral lens corrections spanning the entire phoropter range were separately applied to each eye, followed by ray tracing to determine the residual wavefront aberrations and identify the correction with the highest possible VSX (named a "focus"). To speed up calculations, a smart scanning algorithm was used, consisting of three consecutive scans over increasingly finer dioptric grids. In the dioptric space, the VSX pattern for normal eyes considered over the correction range for either spectacle or scleral lens corrections resembled an hourglass with one distinct focus and a quick drop in VSX away from that focus. For 18 of the 20 keratoconic eyes, the spectacle-corrected VSX pattern resembled a shell that in 9 of the 20 cases showed two foci separated by a large dioptric distance (13.3 ± 4.9 diopters). In keratoconic eyes, scleral lenses also produced hourglass patterns, but with a VSX lower than in normal eyes. The hourglass pattern in dioptric space shows how, in normal eyes, the refracting process automatically funnels practitioners toward the optimal correction. The shell patterns in keratoconus, however, present far more complexity and, possibly, multiple foci. Depending on the starting point, refracting procedures may lead to a local maximum rather than the optimal correction.
Assuntos
Ceratocone , Córnea/diagnóstico por imagem , Humanos , Ceratocone/diagnóstico por imagem , Ceratocone/terapia , Refração Ocular , Esclera , Acuidade VisualRESUMO
Eyes with the corneal ectasia keratoconus have performed better than expected (e.g. visual acuity) given their elevated levels of higher-order aberrations that cause rotationally asymmetric retinal blur. Adapted neural processing has been suggested as an explanation but has not been measured across multiple meridional orientations. Using a custom Maxwellian-view laser interferometer to bypass ocular optics, sinusoidal grating neural contrast sensitivity was measured in six eyes (three subjects) with keratoconus and four typical eyes (two subjects) at six spatial frequencies and eight orientations using a two-interval forced-choice paradigm. Total measurement duration was 24 to 28 hours per subject. Neural contrast sensitivity functions of typical eyes agreed with literature and generally showed the oblique effect on a linear-scale and rotational symmetry on a log-scale (rotational symmetry was quantified as the ratio of the minor and major radii of an ellipse fit to all orientations within each spatial frequency; typical eye mean 0.93, median 0.93; where a circle = 1). Mean sensitivities of eyes with keratoconus were 20% to 60% lower (at lower and higher spatial frequencies respectively) than typical eyes. Orientation-specific neural contrast sensitivity functions in keratoconus showed substantial rotational asymmetry (ellipse radii ratio: mean 0.84; median 0.86) and large meridional reductions. The visual image quality metric VSX was used with a permutation test to combine the asymmetric optical aberrations of the eyes with keratoconus and their measured asymmetric neural functions, which illustrated how the neural sensitivities generally mitigated the detrimental effects of the optics.
Assuntos
Ceratocone , Sensibilidades de Contraste , Topografia da Córnea , Humanos , Óptica e Fotônica , Visão Ocular , Acuidade VisualRESUMO
SIGNIFICANCE: To achieve maximum visual benefit, wavefront-guided scleral lens corrections (WGCs) are aligned with the underlying wavefront error of each individual eye. This requirement adds complexity to the fitting process. With a view toward simplification in lens fitting, this study quantified the consequences of placing WGCs at two pre-defined locations. PURPOSE: This study aimed to quantify performance reduction accompanying the placement of the WGC at two locations: (1) the average decentered location (ADL; average decentration observed across individuals wearing scleral lenses) and (2) the geometric center (GC) of the lens. METHODS: Deidentified residual aberration and lens translation data from 36 conventional scleral lens-wearing eyes with corneal ectasia were used to simulate WGC correction in silico. The WGCs were decentered from the eye-specific pupil position to both the ADL and GC locations. The impact of these misalignments was assessed in terms of change (from the aligned, eye-specific pupil position) in higher-order root mean square (HORMS) wavefront error, change in log of the visual Strehl ratio (logVSX), and predicted change in logMAR visual acuity (VA). RESULTS: As expected, HORMS increased, logVSX decreased, and predicted VA was poorer at both ADL and GC compared with the aligned condition (P < .001). Thirty-four of 36 eyes had greater residual HORMS, and 33 of 36 eyes had worse logVSX values at the GC than at the ADL. In clinical terms, 19 of 36 eyes at the ADL and 35 of 36 eyes at the GC had a predicted loss in VA of three letters or greater. CONCLUSIONS: The placement of the WGC at either ADL or GC is predicted to lead to a noticeable reduction in VA for more than half of the eyes studied, suggesting the simplification of the fitting process is not worth the cost in performance.
Assuntos
Lentes de Contato , Aberrações de Frente de Onda da Córnea/terapia , Ceratocone/terapia , Esclera , Aberrometria , Adulto , Aberrações de Frente de Onda da Córnea/fisiopatologia , Feminino , Humanos , Ceratocone/fisiopatologia , Masculino , Ajuste de Prótese , Pupila/fisiologia , Refração Ocular/fisiologia , Acuidade Visual/fisiologiaRESUMO
SIGNIFICANCE: An equivalent 12 months of cleaning did not induce significant changes in the optical aberrations or base curves of scleral lenses. PURPOSE: This study aimed to test whether an equivalent of 12 months of manual cleaning alters the optical and physical properties of conventional and wavefront-guided scleral lenses. METHODS: Twelve scleral lenses (four repeats of three designs, termed A, B, and C) were manufactured in Boston XO material: design A, -5.00 D defocus; design B, -5.00 D defocus with -0.153-µm vertical coma; and design C, -5.00 D defocus with a full custom wavefront-guided correction (second to fifth Zernike radial orders) of an eye with severe keratoconus. One lens of each design group served as a control and was not cleaned. To simulate a year of cleaning, seven individuals cleaned nine lenses (three from each group) twice a day for 27 days using the palm technique and commercially available cleaners, resulting in 378 cleanings of each lens. Lens aberrations were optically profiled and base curve radii were measured at baseline and after every 42nd cleaning. Differences in higher-order root mean square (HORMS) wavefront error and base curve radii associated with cleaning were compared with clinical benchmarks and using sign tests. RESULTS: For the experimental lenses, median change in Seidel spherical dioptric power was +0.01 D (maximum, +0.025 D). Median change in HORMS wavefront error was 0.013 µm (maximum, 0.019 µm). All lenses exhibited HORMS changes less than one-eighth equivalent diopters (P = .002). Median percentage change in HORMS wavefront error in the three wavefront-guided lenses was 0.96% (maximum, 1.25%). Median change in base curve radii was 0.00 mm, with all lenses exhibiting changes (P = .002), less than the American National Standards Institute tolerance of 0.05 mm. CONCLUSIONS: Cleaning over an equivalent 12-month period did not induce clinically significant changes in the optical or base curve properties of conventional or wavefront-guided scleral lenses.
Assuntos
Soluções para Lentes de Contato/uso terapêutico , Lentes de Contato , Óptica e Fotônica , Esclera , Humanos , Ceratocone/fisiopatologia , Ceratocone/terapia , Exame Físico , Acuidade Visual/fisiologiaRESUMO
SIGNIFICANCE: Scleral lenses (SLs) partially mask higher-order aberrations (HOAs) in highly aberrated eyes. Although visual acuity (VA) may show satisfactory quantitative clinical outcomes during SL wear, residual (uncorrected) HOAs can leave subjective visual quality goals unmet. PURPOSE: The purpose of this study was to report a case where a "20/20 unhappy" patient with SLs was able to meet visual goals with wavefront-guided SLs. CASE REPORT: A 40-year-old male with bilateral keratoconus, whose Snellen VA with SLs was 20/20 right eye (OD) 20/16 left eye (OS), reported halos and glare at night and perceptual smearing. When viewing a point of light, a "Ferris wheel" shadowing was observed OD and a U-shaped shadowing OS. Residual higher-order root mean square wavefront error was 0.49 µm OD and 0.39 µm OS; visual image quality measured by visual Strehl ratio was 0.067 OD and 0.092 OS (pupil size, 4.00 mm). Wavefront-guided SLs reduced residual higher-order root mean square to 0.19 µm OD and 0.25 µm OS, VA improved to 20/10 OD and 20/13 OS, and visual Strehl improved to 0.150 OD and 0.121 OS. The patient reported reduced smearing, shadowing, and night vision concerns, meeting his visual expectations and goals. CONCLUSIONS: Wavefront sensing quantifies both lower and HOAs, which can cause visual dissatisfaction in individuals with highly aberrated eyes, despite sometimes reaching typical levels of VA. As wavefront-guided SLs targeting these residual aberrations to improve visual image quality become more available, they should be considered for 20/20 unhappy patients when conventional clinical options are unsatisfactory.
Assuntos
Lentes de Contato , Aberrações de Frente de Onda da Córnea/terapia , Ceratocone/terapia , Esclera , Transtornos da Visão/terapia , Acuidade Visual/fisiologia , Adulto , Aberrações de Frente de Onda da Córnea/fisiopatologia , Humanos , Ceratocone/fisiopatologia , Masculino , Ajuste de Prótese , Transtornos da Visão/fisiopatologiaRESUMO
PURPOSE: In order to better understand the optical consequence of residual aberrations during conventional rigid contact lens wear in keratoconus, this study aimed to quantify the visual interaction between positive vertical coma (C(3, -1)) and other individual 2nd to 5th radial order Zernike aberration terms. METHODS: The experiment proceeded in two parts. First, two levels of C(3, -1) (target term) were simulated. Individual Zernike aberration terms from the 2nd to 5th radial orders (test terms) were combined in 0.05-µm steps a) from -2.00 µm to +2.00 µm with +1.00 µm of C(3, -1) and b) from -1.00 µm to +1.00 µm with +0.50 µm of C(3, -1). The resulting combinations were used to calculate the logarithm of the visual Strehl ratio (logVSX) and predict the relative beneficial or deleterious impact of the interaction. Second, for test terms where an interaction was predicted to provide more than a 0.25 logVSX benefit compared to C(3, -1) alone, high contrast logMAR acuity charts were constructed (simulating the manner in which the test + target term combinations would impact the retinal image of the chart), and randomly read by three well-corrected, typically-sighted individuals through a 3.0-mm diameter artificial pupil. RESULTS: When combined with positive C(3, -1), C(3, -3), C(4, -4), C(5, -5), C(5, -3), and C(5, -1) exhibited better visual image quality compared with C(3, -1) alone. Ratios of the test terms to target term providing maximal benefit remained constant for both +0.50 µm and +1.00 µm of C(3, -1). C(3, -3) and C(5, -1) had the largest predicted beneficial effect, with the maximal effect for +1.00 µm of C(3, -1) occurring with +0.35 µm of C(5, -1) and -1.00 µm of C(3, -3). When individuals read letter charts convolved with the point spread function derived from C(3, -1) combined with C(3, -3) and C(3, -1) combined with C(5, -1), the maximal beneficial effect was 0.27 logMAR (13.5 letters) for C(3, -3) and 0.36 logMAR (18 letters) for C(5, -1). CONCLUSIONS: While most interactions reduced visual image quality, combinations of C(3, -3) (vertical trefoil) and C(5, -1) (vertical secondary coma) provided a clinically relevant beneficial effect in the presence of C(3, -1) (vertical coma) which was demonstrated in both through-focus simulation and chart reading tests. Future work will examine whether these effects persist in the presence of the entire spectrum of residual aberrations seen in the eyes of individuals with keratoconus.
Assuntos
Lentes de Contato , Ceratocone/fisiopatologia , Refração Ocular/fisiologia , Acuidade Visual , Adulto , Topografia da Córnea , Feminino , Humanos , Ceratocone/diagnóstico , Ceratocone/terapia , MasculinoRESUMO
Visual image quality metrics combine comprehensive descriptions of ocular optics (from wavefront error) with a measure of the neural processing of the visual system (neural contrast sensitivity). To improve the ability of these metrics to track real-world changes in visual performance and to investigate the roles and interactions of those optical and neural components in foveal visual image quality as functions of age and target luminance, models of neural contrast sensitivity were constructed from the literature as functions of (1) retinal illuminance (Trolands, td), and (2) retinal illuminance and age. These models were then incorporated into calculation of the visual Strehl ratio (VSX). Best-corrected VSX values were determined at physiological pupil sizes over target luminances of 104 to 10-3 cd/m2 for 146 eyes spanning six decades of age. Optical and neural components of the metrics interact and contribute to visual image quality in three ways. At target luminances resulting in >900 td at physiological pupil size, neural processing is constant, and only aberrations (that change as pupil size changes with luminance) affect the metric. At low mesopic luminances below where pupil size asymptotes to maximum, optics are constant (maximum pupil), and only the neural component changes with luminance. Between these two levels, both optical and neural components of the metrics are affected by changes in target luminance. The model that accounted for both retinal illuminance and age allowed VSX, termed VSX(td,a), to best track visual acuity trends (measured at 160 and 200 cd/m2) as a function of age (20s through 70s) from the literature. Best-corrected VSX(td,a) decreased by 2.24 log units between maximum and minimum target luminances in the youngest eyes and by 2.58 log units in the oldest. The decrease due to age was more gradual at high target luminances (0.70 log units) and more pronounced as target luminance decreased (1.04 log units).
Assuntos
Envelhecimento/fisiologia , Luz , Retina/fisiologia , Percepção Visual/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Sensibilidades de Contraste/fisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pupila/fisiologia , Visão Ocular/fisiologia , Acuidade Visual/fisiologia , Adulto JovemRESUMO
PURPOSE: To demonstrate the necessity of aligning a wavefront-guided scleral lens (WGSL) optical correction to the eye's effective pupil, with misalignments leading to reduced performance. CASE REPORT: A 34 year old subject with a history of failed LASIK in the left eye, leading to penetrating keratoplasty, extracapsular extraction of the crystalline lens and neodymium:yttrium-aluminum-garnet (Nd:YAG) laser posterior capsulotomy, enrolled in a study examining WGSL performance. Habitual logMAR acuity OS (aided with a scleral lens) was +0.04. Residual higher order root mean square (HORMS) wavefront error (WFE) was 0.28 µm (Φ =4.75 mm, mean age-matched norm =0.17 µm), and objective over-refraction was -0.30 -0.54 × 008. When a WGSL (targeting aberrations up to the 5 th radial order) was manufactured with the wavefront-guided optics aligned to the center of the dilated pupil, logMAR acuity worsened to +0.15, residual HORMS WFE worsened to 0.44 µm (Φ =4.75 mm), and objective over-refraction increased to +1.19 -0.30 × 122. Slit lamp imagery revealed that the effective pupil was no longer defined by the iris of the eye, but rather the capsular opening created by the capsulotomy. When the WGSL was redesigned to align the wavefront-guided optics to the center of the capsular opening, logMAR acuity improved to -0.14, residual HORMS WFE reduced to 0.17 µm (Φ =4.75 mm) and objective over-refraction reduced to +0.20 -0.15 × 111. CONCLUSION: WGSLs are an emerging option for patients with highly aberrated, ectatic and post-surgical corneas whose visual symptoms cannot be alleviated with conventional corrections. However, alignment of the optics of the WGSL to the underlying optics of the eye over the effective pupil is critical in achieving good optical and visual performance.
Assuntos
Lentes de Contato , Aberrações de Frente de Onda da Córnea , Ceratocone , Cristalino , Adulto , Humanos , Refração Ocular , Acuidade VisualRESUMO
SIGNIFICANCE: The findings of this study indicate that patients could simultaneously be offered the individualized optical correction of wavefront-guided (WFG) lenses and the superior comfort afforded by polymer coatings. This could be helpful to patients with ectasia suffering ocular dryness or dependent on scleral lenses for lengthy periods of wear. PURPOSE: Wavefront-guided scleral lenses target lower- and higher-order aberrations of individual eyes using submicrometer-level contours in the anterior lens surface. Hydrophilic polyethylene glycol (PEG) polymer coatings applied to lens surfaces improve comfort and wettability. This study aimed to quantify aberration changes (e.g., masking) when applying polymer coatings to WFG and conventional scleral lenses. METHODS: Two control lenses (remained uncoated) and 14 experimental lenses (two repeated builds of seven aberration designs: one spherical, two coma, four full WFG [second- to fifth-order aberrations]) were manufactured, and aberrations were measured (mean of three) by two operators before and after coating. Root mean square (RMS) and visual image quality (logVSX) differences were calculated for 6-mm diameters. RESULTS: Median RMS aberration change due to coating was 0.012 µm (range, 0.008 to 0.057 µm). Maximum logVSX change due to coating was 0.073, predicting an approximately one letter change in acuity. Instrument sensitivity was 0.002 µm. Acute instrument and operator variabilities (standard deviations of individual [second- to fifth-order Zernikes] were all <0.027 µm). Longitudinal variability (control lenses) was low: all less than 0.017 µm. Although RMS of differences between repeated builds of all lenses was less than 0.25 D and not statistically significant, relatively, manufacture constituted the major variability, and RMS difference between repeated builds was at least four times greater than the effect of coating (median, 0.167 µm; range, 0.088 to 0.312 µm). CONCLUSIONS: Application of polymer coatings caused measurable changes in aberrations of WFG and conventional scleral lenses; however, these were clinically and statistically insignificant and within variability of repeated lens manufacture. In their current states, WFG lenses and polymer coatings could be used simultaneously.
Assuntos
Materiais Revestidos Biocompatíveis , Lentes de Contato , Aberrações de Frente de Onda da Córnea/fisiopatologia , Polietilenoglicóis , Esclera , Adulto , Feminino , Humanos , Masculino , Refração Ocular/fisiologia , Acuidade Visual/fisiologiaRESUMO
SIGNIFICANCE: Visual performance with wavefront-guided (WFG) contact lenses has only been reported immediately after manufacture without time for habituation, and comparison has only been made with clinically unrefined predicate conventional lenses. We present comparisons of habitual corrections, best conventional scleral lenses, and WFG scleral lenses after habituation to all corrections. PURPOSE: The purpose of this study was to compare, in a crossover design, optical and visual performance of eyes with corneal ectasias wearing dispensed best conventional scleral lens corrections and dispensed individualized WFG scleral lens corrections. METHODS: Ten subjects (20 eyes) participated in a randomized crossover study where best conventional scleral lenses and WFG scleral lenses (customized through the fifth radial order) were worn for 8 weeks each. These corrections, as well as each subject's habitual correction and normative data for normal eyes, were compared using (1) residual higher-order aberrations (HORMS), (2) visual acuity (VA), (3) letter contrast sensitivity (CS), and (4) visual image quality (logarithm of the visual Strehl ratio, or logVSX). Correlations were performed between Pentacam biometric measures and gains provided by WFG lenses. RESULTS: Mean HORMS was reduced by 48% from habitual to conventional and 43% from conventional to WFG. Mean logMAR VA improved from habitual (+0.12) to conventional (-0.03) and further with WFG (-0.09); six eyes gained greater than one line with WFG over conventional. Area under the CS curve improved by 26% from habitual to conventional and 14% from conventional to WFG. The percentage of the eyes achieving normal levels were as follows: HORMS, 40% for conventional and 85% for WFG; VA, 50% for conventional and 85% for WFG; and CS, 60% for conventional and 90% for WFG. logVSX improved by 16% from habitual to conventional and 25% further with WFG. Reduction in aberrations with WFG lenses best correlated with posterior cornea radius of curvature. CONCLUSIONS: Visual performance was superior to that reported with nonhabituated WFG lens wear. With WFG lenses, HORMS and logVSX significantly improved, allowing more eyes to reach normal levels of optical and visual performance compared with conventional lenses.
Assuntos
Lentes de Contato , Aberrações de Frente de Onda da Córnea/fisiopatologia , Habituação Psicofisiológica/fisiologia , Ceratocone/terapia , Esclera , Adulto , Estudos Cross-Over , Dilatação Patológica , Feminino , Humanos , Ceratocone/fisiopatologia , Masculino , Pessoa de Meia-Idade , Acuidade Visual/fisiologia , Adulto JovemRESUMO
The visual image quality metric the visual Strehl ratio (VSX) combines a comprehensive description of the optics of an eye (wavefront error) with an estimate of the photopic neural processing of the visual system, and has been shown to be predictive of subjective best focus and well correlated with change in visual performance. Best-corrected visual image quality was determined for 146 eyes, and the quantitative relation of VSX, age, and pupil size is presented, including 95% confidence interval norms for age groups between 20 and 80 years and pupil diameters from 3 to 7 mm. These norms were validated using an independently collected population of wavefront error measurements. The best visual image quality was found in young eyes at smaller pupil sizes. Increasing pupil size caused a more rapid decrease in VSX than increasing age. These objectively determined benchmarks represent the best theoretical levels of visual image quality achievable with a sphere, cylinder, and axis correction in normal eyes and can be used to evaluate both traditional and wavefront-guided optical corrections provided by refractive surgery, contact lenses, and spectacles.