[Diagnosis of postpartum abdominal pain: about a rare case of portal vein thrombosis]. / Orientation diagnostique devant des douleurs abdominales du post-partum: à propos d'un cas rare de thrombose portale.

We report the management of patient with acute abdominal pain in the immediate post-partum caesarean section performed in the context of preeclampsia. Acute portal vein thrombosis is diagnosed, in a patient with no personal or family history of venous thrombosis. Blood tests showed a protein C and S deficiencies. Portal vein thrombosis is an extremely rare occurrence in pregnancy and postpartum.

[Demethylation and blood dosage of antidepressive imipramine drugs. Preliminary note]. / Déméthylation et dosage des antidépresseurs imipraminiques dans le sang. Note préliminaire.

The ability to demethylate the classical imipraminic antidepressants is a key factor for the immediate and long-term management of long cycles primary unipolar depressions. These are preliminary observations concerning two different cases of a well-demethylating patient, and a badly-demethylating one.

[Staff-patient meetings at the psychiatric unit of a university hospital center]. / Réunion soignants-soignés dans un service de psychiatrie de C.H.U.

Staff/patients meetings have been held for 10 years within a mental teaching hospital for adults. The meeting was initiated by a clinical psychologist still in charge of it. The patients have developed the following themes: (i) entrance conditions, (ii) everyday life information, (iii) inconveniences, (iv) mental illness, (v) the exclusion process. The least severely affected patients will exclude the other ones on ground of insanity. Yet all patients consider themselves banned from society, and even feel rejected by the stall at times. The meeting is meant as a regular talk scène. Individual or collective conflicts arising between the patients can be settled there. Patient passivity may also be counteracted. Staff seminar should work up clearly the data provided by the meeting.

[Clomipramine and demethylclomipramine. Correlation of plasma levels and efficacy in 24 depressive patients]. / Clomipramine et déméthylclomipramine. Corrélation taux plasmatiques/efficacité chez 24 déprimés.

Plasma concentrations of clomipramine (CL) and demethylclomipramine (DMCL) were determined in 24 patients with an endogenous (9) or non endogenous (15) depressive syndrome, treated in hospital for 21 days, with clomipramine; simultaneous clinical evaluations were performed with Hamilton Rating Scale. Optimal therapeutic effect was observed when the sum of CL + DMCL plasma levels was less 200 ng/ml or more 400 ng/ml. In our responders, the CL/DMCL ratio was around 0.6. The relation between demethylation and clinical outcome is considered.

[Plasma levels of clomipramine and declomipramine in patients with depression: a study of its correlation with therapeutic efficacy]. / Concentrations plasmatiques de clomipramine et de déclomipramine chez des patients atteints de dépression: recherche de corrélations avec l'efficacité thérapeutique.

Twenty four in-patients with an endogenous or non endogenous depressive syndrome (9 and 15, respectively) were treated in hospital for 21 days with various dosages regimens of clomipramine. Plasma concentrations of clomipramine and demethylclomipramine were determined once a week in blood samples. Therapeutic effects were assessed with Hamilton Rating Scale. At day 21, optimal therapeutic effect was observed when the sum of clomipramine and demethylclomipramine plasma levels was situated between 200-400 ng/ml.

[A peripheral biological marker of organicity. Chromosome mosaic anomalies in general psychiatry]. / Un marqueur biologique périphérique d'organicité. Les anomalies chromosomiales en mosaïques en psychiatrie générale.

During February 1979 to December 1982 we studied the karyotype of 706 psychiatric adult patients without making a clinical selection. We found a chromosomial mosaïc aberration in 37 cases, concerning one leukocyte mitosis for ten studied cells : so a proportion of 5.2% cases. There do not exist statistics concerning the general population's mosaïc aberrations but in the same population the proportion of the homogeneous aberrations is near 0.5%, so 10 times lower than the proportion that we observed. The largest number of aberrations found concern the gonosomes, essentially some monosomics 45,XO or some trisomics 47,3X, among women who present a maniac depressive psychosis or another type of depression.

[Lewis-negative blood group. Definite frequency, probable prognostic value in adult psychiatry]. / Groupe sanguin Lewis négatif. Fréquence certaine, valeur pronostique probable en psychiatrie de l'adulte.

The negative Lewis blood type is meaningfully more frequent with our psychiatric patients than with the general population. The theoretical interest of this fact is certain for the reason of two particularities of this blood type. It is not genetically and definitely determined at birth: the absence of passing over negativity through positivity seems to constitute a factor in favour of the blossoming of a psychiatric pathology. It is in connection with the secretory aptitude of some cells: this fact opens some perspectives for the comprehension of the deficits in the neurotransmitters. The application of theory will be confirmed by others statistics. But it indeed appears that the control of the chemiotherapy is more difficult with the negative Lewis blood type patients.