Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 16 de 16
Filtrar
1.
Contemp Clin Trials Commun ; 4: 1-8, 2016 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-29736465

RESUMO

Since it was introduced by Noon in 1911, allergen-specific immunotherapy or desensitization has been widely prescribed in the management of allergic diseases. Aimed at the etiology, it represents the only effective treatment for allergy. The basic mechanisms of immunotherapy are becoming better understood and allow us to improve this technique in the future. The sublingual immunotherapy as an alternative to subcutaneous route has been widely studied. Several clinical trials confirmed that sublingual immunotherapy is efficient in reducing allergic respiratory symptoms. The sublingual immunotherapy reduces the risk of developing serious side effects due to desensitization. We performed a literature review in order to remind the mechanisms of action and to demonstrate efficacy and tolerability of the sublingual immunotherapy in the treatment of allergic rhinoconjunctivitis and asthma and its impact on the quality of life.

2.
Rev Pneumol Clin ; 71(5): 311-7, 2015 Oct.
Artigo em Francês | MEDLINE | ID: mdl-26190337

RESUMO

BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is a highly prevalent clinical condition and frequently associated with obesity. Recent literature has suggested the independent contribution of OSAS in the pathogenesis of metabolic disturbances. Metabolic syndrome (MS), a cardiovascular risk factor, was frequently associated with OSAS. METHODS: This is a prospective study without intervention. Will be included, all consecutive patients referred to the Department of Pulmonology for suspected OSAS confirmed by respiratory polygraphy. Anthropometric, clinical and biological parameters needed to define the MS will be collected. MS was defined according to the IDF 2005. Assessment of cardiovascular risk related to MS will be performed by appropriate scores. EXPECTED RESULTS: To determine the prevalence of MS in a sample of OSAS patients recruited in the Department of Pulmonology of Farhat Hached Hospital (Sousse, Tunisia). To identify risk factors independently associated with the presence of MS in patients with OSAS among the following parameters (age, gender, degree of obesity and the various parameters of OSAS severity). To assess compared cardiovascular risks according to the presence of MS by validated scales to demonstrate the impact of MS in patients with OSAS.


Assuntos
Síndrome Metabólica/epidemiologia , Apneia Obstrutiva do Sono/epidemiologia , Doenças Cardiovasculares/prevenção & controle , Humanos , Prevalência , Estudos Prospectivos , Medição de Risco , Tunísia/epidemiologia
4.
Rev Pneumol Clin ; 67(6): 347-53, 2011 Dec.
Artigo em Francês | MEDLINE | ID: mdl-22137278

RESUMO

BACKGROUND: Promoting a smoke-free hospital is a priority component for tobacco control strategies. The aim of our investigation was to study the attitudes and behaviors of the hospital staff of the F.-Hached UH of Sousse towards smoking, and to assess their knowledge about the harms of passive smoking and about tobacco regulations in the hospital. METHODS: We conducted a descriptive cross-sectional study using an anonymous self-administered questionnaire. In January-February 2008, the questionnaire was submitted to hospital staff members selected at random from the care units at F.-Hached UH of Sousse, Tunisia. RESULTS: The response rate was 92.8% (452 participants). The average age of the population was 39.7±19 years; all professional categories were represented. The prevalence of active smoking among the staff interviewed was 19% (89.5% males). About 75% of the smokers stated they smoked on the work site and 8% in the presence of patients. The majority of the smokers wished to stop smoking. Discomfort from exposure to tobacco smoke was reported by 83.4% of respondents. The large majority of staff respondents (95%) knew that tobacco smoke is dangerous and 80% were aware of the existence of a law that prohibits smoking in the hospital. CONCLUSION: The prevalence of smoking remains high among male hospital workers. In our hospital, the majority of the care staff favored promotion of a tobacco-free hospital. The success of this project will depend on education, implicating the entire hospital staff in the anti-smoking battle. Smoking staff members should be supported in their attempts to stop smoking.


Assuntos
Fidelidade a Diretrizes/estatística & dados numéricos , Comportamentos Relacionados com a Saúde , Conhecimentos, Atitudes e Prática em Saúde , Fumar/legislação & jurisprudência , Fumar/psicologia , Poluição por Fumaça de Tabaco/legislação & jurisprudência , Adulto , Idoso , Atitude do Pessoal de Saúde , Estudos Transversais , Coleta de Dados , Feminino , Hospitais Universitários/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Fumar/epidemiologia , Prevenção do Hábito de Fumar , Poluição por Fumaça de Tabaco/prevenção & controle , Poluição por Fumaça de Tabaco/estatística & dados numéricos , Tunísia/epidemiologia , Adulto Jovem
5.
Rev Pneumol Clin ; 65(3): 147-52, 2009 Jun.
Artigo em Francês | MEDLINE | ID: mdl-19524803

RESUMO

Patients with obstructive sleep apnea/hypopnea syndrome (OSAHS) treated by continuous positive airway pressure (CPAP) need to use long-term CPAP to prevent cardiovascular disease. The method of survival analysis was used to allow for long-term CPAP use in 72 patients who were prescribed a CPAP. During a mean follow-up of 22+/-15 months, one patient died and 17 patients stopped their treatment, 29% of them in the first 6 months. In compliant patients, the median value of daily CPAP use was 4.5hours. Kaplan Meier analysis showed that 92% of patients were still using CPAP at 6 months, 83% at 12 months and 59.9% at 3 years. Chronic obstructive pulmonary disease was identified as a predictor factor of long-term CPAP use (OR=4.53, p=0.01). CPAP is a well-accepted long-term therapy for OSAHS with 60% of patients continuing to be compliant with treatment at 3 years.


Assuntos
Pressão Positiva Contínua nas Vias Aéreas/estatística & dados numéricos , Cooperação do Paciente , Apneia Obstrutiva do Sono/terapia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Doença Pulmonar Obstrutiva Crônica/epidemiologia
6.
Rev Pneumol Clin ; 65(1): 9-12, 2009 Feb.
Artigo em Francês | MEDLINE | ID: mdl-19306777

RESUMO

Pneumonia caused by varicella infection is a serious and severe complication of the disease when it occurs in adults. The authors report two cases of a varicella pneumonia in a 36 and a 41 year-old non-immunocompromised man. They were admitted to hospital for acute respiratory failure, not requiring intensive care, associated with exanthema. High resolution CT revealed well-defined diffuse nodules throughout both lungs, nodules with a surrounding halo of ground-glass opacity. Thrombocytopenia, hepatic cytolysis and an increase in lacticodeshydrogenase were noted. The patients made a full recovery with anti-viral therapy and oxygen therapy. Varicella pneumonia is the most common complication of varicella in adults. Anti-viral treatment is usually successful.


Assuntos
Varicela/complicações , Pneumonia Viral/diagnóstico , Pneumonia Viral/virologia , Adulto , Antivirais/uso terapêutico , Humanos , Imunocompetência , Masculino , Oxigenoterapia , Pneumonia Viral/terapia , Insuficiência Respiratória/virologia
7.
Rev Pneumol Clin ; 62(1): 13-8, 2006 Feb.
Artigo em Francês | MEDLINE | ID: mdl-16604035

RESUMO

The tubercular pneumothorax is a rare and severe form of tuberculosis which persists in Tunisia. We reviewed retrospectively our experience at the Pneumology-Allergology Department of the Sousse Hospital with 23 cases of tubercular pneumothorax observed between 1985 and 2003. The suggestive symptom, pneumothorax, always occurred within a context poor general health and fever. The chest roentgengraph showed pneumothorax (n=8) or hydropneumothorax (n=15), and pulmonary lesions associated in 82.5% of patients. Bacteriological proof was obtained in 21 cases; in the two other patients, histological examination of the surgical specimen was highly suggestive of tuberculosis. Treatment associated antitubercular chemotherapy in compliance with the National Plan of against Tuberculosis (n=23), chest drainage (n=21) and respiratory physiotherapy (n=18). Five patients underwent surgery: pleural decortications (n=3), pulmonary resections (n=2). Two were lost to follow-up. The course was favourable in 78% of patients; there were two cases of partitioned pyopneumothorax and one post-operative death. In our experience, tubercular pneumothorax was always associated with active cavitated tuberculosis. The course was almost favorable with antitubercular chemotherapy and chest drainage.


Assuntos
Pneumotórax/complicações , Tuberculose Pulmonar/complicações , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pneumotórax/terapia , Estudos Retrospectivos , Tuberculose Pulmonar/terapia , Tunísia
8.
Rev Pneumol Clin ; 61(1 Pt 1): 50-2, 2005 Feb.
Artigo em Francês | MEDLINE | ID: mdl-15772582

RESUMO

We report the case of a 15-year-old girl with osteosarcoma in the left distal femur who developed a recurrent spontaneous pneumothorax. The patient was treated by neoadjuvant chemotherapy followed by surgery (limb-sparing surgical procedure with insertion of a knee prosthesis) and then adjuvant chemotherapy. The initial extension assessment was normal. No pulmonary metastasis was found. The chest tomography performed at the end of treatment (8 months after surgery) revealed two peripheral pulmonary nodules not seen on the chest X-ray. Palliative chemotherapy was given, the thoracic tomography after four chemotherapy courses showed a progress of the pulmonary metastasis and on the right more abundant bilateral pneumothorax which had recurred two months after thoracic draining. Thoracoscopy showed no pleural lesions.


Assuntos
Neoplasias Ósseas/patologia , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/secundário , Osteossarcoma/complicações , Osteossarcoma/secundário , Pneumotórax/etiologia , Adolescente , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Ósseas/tratamento farmacológico , Neoplasias Ósseas/cirurgia , Feminino , Fêmur/patologia , Humanos , Osteossarcoma/tratamento farmacológico , Osteossarcoma/cirurgia , Cuidados Paliativos , Recidiva
9.
Rev Pneumol Clin ; 61(6): 387-9, 2005 Dec.
Artigo em Francês | MEDLINE | ID: mdl-16449930

RESUMO

We report the case of a 42-year-old woman operated for neurofibroma of the scalp on two occasions who consulted for bilateral chest pain which reveated two voluminous bilateral pulmonary masses. Biopsy of one of these masses was in favor of secondary or primary leiomyosarcoma. The association of Von Recklinghausen's disease and soft tissue sarcoma is rare: most often neurofibroma which degenerates is observed. Other types of sarcoma, like leiomyosarcoma, have been described.


Assuntos
Leiomiossarcoma/patologia , Neoplasias Pulmonares/patologia , Neurofibromatose 1/patologia , Adulto , Biópsia , Dor no Peito/etiologia , Comorbidade , Feminino , Lateralidade Funcional , Humanos , Leiomiossarcoma/diagnóstico por imagem , Neoplasias Pulmonares/diagnóstico por imagem , Segunda Neoplasia Primária , Neurofibromatose 1/cirurgia , Radiografia Torácica , Couro Cabeludo/patologia , Tomografia Computadorizada por Raios X
10.
Rev Mal Respir ; 14(1): 53-4, 1997 Jan.
Artigo em Francês | MEDLINE | ID: mdl-9082506

RESUMO

A mediastinal hydatid cyst is rare (< 0.1% of hydatidosis). It most frequently progresses to calcification rather than a pulmonary hydatid cyst because there is no relationship to ventilation. We report a case of calcified mediastinal hydatid cyst which was confirmed on histological examinations from the operative specimen, in an agricultural worker of 58 who presented with a homolateral paralysed diaphragm.


Assuntos
Doenças dos Trabalhadores Agrícolas/parasitologia , Calcinose/complicações , Equinococose/complicações , Doenças do Mediastino/complicações , Paralisia Respiratória/parasitologia , Biópsia , Calcinose/diagnóstico , Calcinose/cirurgia , Equinococose/diagnóstico , Equinococose/cirurgia , Humanos , Masculino , Doenças do Mediastino/diagnóstico , Doenças do Mediastino/cirurgia , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
11.
Int J Tuberc Lung Dis ; 1(5): 477-81, 1997 Oct.
Artigo em Francês | MEDLINE | ID: mdl-9441105

RESUMO

The frequency of tuberculous cerebral involvement associated with miliary tuberculosis is not well known; some authors have evaluated it at around 22%. We report the case of a 43-year-old man hospitalised in the pulmonology department with bacillary positive miliary tuberculosis. On the 26th day of antituberculosis treatment he complained of frontal headaches, with impairment in visual acuity. Examination of the optic fundus showed bilateral papillary oedema. Cerebral computed tomography showed diffuse rounded lesions with significant oedema. Antituberculosis chemotherapy was supplemented with steroid treatment. Clinical and radiological progress was good.


Assuntos
Tuberculoma Intracraniano , Tuberculose Miliar , Adulto , Antituberculosos/uso terapêutico , Cosintropina/uso terapêutico , Humanos , Masculino , Tomografia Computadorizada por Raios X , Tuberculoma Intracraniano/diagnóstico por imagem , Tuberculoma Intracraniano/tratamento farmacológico , Tuberculose Miliar/diagnóstico por imagem , Tuberculose Miliar/tratamento farmacológico
12.
Rev Mal Respir ; 14(6): 485-8, 1997 Dec.
Artigo em Francês | MEDLINE | ID: mdl-9496608

RESUMO

We report a case of 33 year old man who consulted us in 1994 for recurrent bronchitis sometimes with haemoptysis. The physical examination was unremarkable. At consultation abnormal fascicular sounds were noted at the left base. A chest x-ray showed hyperlucency of the left lung associated with a very small left hilar shadow. We considered the diagnosis of Mac Leod's syndrome after eliminating a proximal obstructive pathology and pulmonary embolus. Mac Leod's syndrome or Swyer James' syndrome was described in 1954 and is suggested on the standard radiograph above all if the expiratory films have confirmed the presence of air trapping. Angiography shows a slender and fine pulmonary network. Computer tomographic examination of the chest rules out a bronchial tumour, excludes bullous emphysema and reveals hyperlucent zones. Scintigraphy with ventilation perfusion supplies the essentials to understanding the mechanism (a syndrome of aerated lung which is neither directly ventilated nor perfused). The expiratory function tests most often show a restrictive syndrome but sometimes an obstructive syndrome is found with associated air trapping. The disorder does not progress and the prognosis is good.


Assuntos
Pulmão Hipertransparente/diagnóstico , Adulto , Angiografia , Bronquite/diagnóstico , Broncoscopia , Diagnóstico Diferencial , Fluxo Expiratório Forçado , Hemoptise/diagnóstico , Humanos , Pulmão Hipertransparente/diagnóstico por imagem , Masculino , Prognóstico , Cintilografia , Tomografia Computadorizada por Raios X , Relação Ventilação-Perfusão
14.
Am Rev Respir Dis ; 146(1): 185-9, 1992 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-1626801

RESUMO

During a 10-yr period, 386 patients with hydatid disease of the lung were treated at our hospital. There were 165 male and 221 female patients with a mean age of 30.15 + 16.9 yr. There were 286 solitary, 20 multiple, and 21 bilateral cysts. In 59 patients, the cysts included the lung and other organs; in 54, the lung and the liver; in four, the lung and the kidney; in one, the lung and the peritoneum. Diagnosis was made using clinical criteria, serologic findings, and imaging techniques; 373 patients were treated surgically. Surgical procedures consisted of cystectomy in 93 patients, pericystectomy in 166 patients, and lung resection in 114 patients. Mebendazole and flubendazole were used in three patients. Postoperative complications occurred in 44 patients (15.8%). There were two operative deaths (mortality rate, 0.53%). Patients have been followed yearly, with a median follow-up of 6 yr. Active hydatid disease has been found in two patients.


Assuntos
Equinococose Pulmonar , Adulto , Idoso , Criança , Pré-Escolar , Equinococose Pulmonar/diagnóstico , Equinococose Pulmonar/diagnóstico por imagem , Equinococose Pulmonar/cirurgia , Feminino , Humanos , Pulmão/diagnóstico por imagem , Pulmão/patologia , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Radiografia
16.
Eur Respir J ; 5(3): 365-7, 1992 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-1374039

RESUMO

Although blastomycosis is prevalent in the North American continent, it occurs only sporadically in Africa. We describe a 42 yr old patient who complained of intermittent cough and haemoptysis. Clinical findings were strongly suggestive of lung cancer. The diagnosis of pulmonary blastomycosis was made at thoracotomy. This rather unusual disease in our areas caused a considerable delay in securing the diagnosis and we suggest that this infection may be found elsewhere in Africa and the distribution may be wider than has previously been suspected.


Assuntos
Blastomyces/isolamento & purificação , Blastomicose/diagnóstico , Pneumopatias Fúngicas/diagnóstico , Pulmão/microbiologia , Adulto , Blastomyces/efeitos dos fármacos , Blastomicose/tratamento farmacológico , Humanos , Cetoconazol/uso terapêutico , Pulmão/diagnóstico por imagem , Pulmão/patologia , Pneumopatias Fúngicas/tratamento farmacológico , Masculino , Coloração e Rotulagem/métodos , Tomografia Computadorizada por Raios X , Tunísia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA