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1.
Sci Bull (Beijing) ; 69(1): 114-124, 2024 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-37989675

RESUMO

As one of the world's largest emitters of greenhouse gases, China has set itself the ambitious goal of achieving carbon peaking and carbon neutrality. Therefore, it is crucial to quantify the magnitude and trend of sources and sinks of atmospheric carbon dioxide (CO2), and to monitor China's progress toward these goals. Using state-of-the-art datasets and models, this study comprehensively estimated the anthropogenic CO2 emissions from energy, industrial processes and product use, and waste along with natural sources and sinks of CO2 for all of China during 1980-2021. To recognize the differences among various methods of estimating greenhouse emissions, the estimates are compared with China's National Greenhouse Gas Inventories (NGHGIs) for 1994, 2005, 2010, 2012, and 2014. Anthropogenic CO2 emissions in China have increased by 7.39 times from 1980 to 12.77 Gt CO2 a-1 in 2021. While benefiting from ecological projects (e.g., Three Norths Shelter Forest System Project), the land carbon sink in China has reached 1.65 Gt CO2 a-1 averaged through 2010-2021, which is almost 15.81 times that of the carbon sink in the 1980s. On average, China's terrestrial ecosystems offset 14.69% ± 2.49% of anthropogenic CO2 emissions through 2010-2021. Two provincial-level administrative regions of China, Xizang and Qinghai, have achieved carbon neutrality according to our estimates, but nearly half of the administrative regions of China have terrestrial carbon sink offsets of less than 10% of anthropogenic CO2 emissions. This study indicated a high level of consistency between NGHGIs and various datasets used for estimating fossil CO2 emissions, but found notable differences for land carbon sinks. Future estimates of the terrestrial carbon sinks of NGHGIs urgently need to be verified with process-based models which integrate the comprehensive carbon cycle processes.

2.
World J Surg Oncol ; 21(1): 62, 2023 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-36841776

RESUMO

BACKGROUND: With the advance in genome-wide analyses, genetic alternations have been found to play an important role in carcinogenesis and aggressiveness of UC. Through bioinformatic analysis of gene expression profiles of urinary bladder urothelial carcinoma (UBUC) from publicly available GEO dataset (GSE31684), Zinc finger and SCAN domain containing 4 (ZSCAN4) was identified as a significant downregulated gene in muscle-invasive bladder cancer when compared with non-muscle-invasive bladder cancer. METHODS: The expression of ZSCAN4 was evaluated by immunohistochemistry in 340 upper urinary tract urothelial carcinomas (UTUCs) and 295 UBUCs. The expression profiles of ZSCAN4 and potential signaling pathways were analyzed bioinformatically. RESULTS: In UTUC, low expression of ZSCAN4 was significantly associated with advanced primary pT stage (P = 0.011), increased nodal metastasis (P = 0.002) and increased vascular invasion (P = 0.019). In UBUC, low expression of ZSCAN4 was significantly correlated with advanced primary pT stage (P < 0.001), increased nodal metastasis (P = 0.001), high histological grade (P = 0.003) and increased vascular invasion (P = 0.003). In survival analysis, low expression of ZSCAN4 acted as an independent negative prognostic factor for disease-specific survival and metastasis-free survival both in UTUC and UBUC. Gene ontology analysis showed that ZSCAN4 mRNA and its co-downregulated genes are associated with the mitotic cell cycle. CONCLUSIONS: Low expression of ZSCAN4 predicted worse outcome in urothelial carcinoma and might have potential regulatory role in cell mitosis.


Assuntos
Carcinoma de Células de Transição , Neoplasias da Bexiga Urinária , Humanos , Neoplasias da Bexiga Urinária/patologia , Carcinoma de Células de Transição/patologia , Bexiga Urinária/patologia , Estudo de Associação Genômica Ampla , Prognóstico , Pelve Renal/patologia , Proteínas de Ligação a DNA/genética , Fatores de Transcrição/genética
3.
Sci Total Environ ; 855: 158819, 2023 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-36116661

RESUMO

Increasingly drastic global change is expected to cause hydroclimatic changes, which will influence vegetation productivity and pose a threat to the terrestrial carbon sink. Asymmetry represents an imbalance between vegetation growth and loss of growth during dry and wet periods, respectively. However, the mechanisms of asymmetric plant responses to hydrological changes remain poorly understood. Here, we examined the spatiotemporal patterns of asymmetric responses of vegetation productivity across terrestrial ecosystems in China. We analyzed several observational and satellite-based datasets of plant productivity and several reanalyzed datasets of hydroclimatic variables from 2001 to 2020, and used a random forest model to assess the importance of hydroclimatic variables for these responses. Our results showed that the productivity of >50 % of China's vegetated areas showed a more positive asymmetry (2.3 ± 9.4 %) over the study period, which were distributed broadly in northwest China (mainly grasslands and sparse vegetation ecosystems). Negative asymmetries were most common in forest ecosystems in northeast China. We demonstrated that one-third of vegetated areas tended to exhibit significant changes in asymmetry during 2001-2020. The trend towards stronger positive asymmetry (0.95 % yr-1) was higher than that towards stronger negative asymmetry (-0.55 % yr-1), which is beneficial for the carbon sink. We further showed that in China, soil moisture was a more important driver of spatiotemporal changes in asymmetric productivity than precipitation. We identified thresholds of surface soil moisture (20-30 %, volume water content) and root-zone soil moisture (200-350 mm, equivalent water height) that were associated with changes in asymmetry. Our findings highlight the necessity of considering the dynamic responses of vegetation to hydrological factors in order to fully understand the physiological growth processes of plants and avoid the possible loss of productivity due to future climate change.


Assuntos
Ecossistema , Solo , Mudança Climática , Sequestro de Carbono , Plantas , Água , China
4.
J Environ Manage ; 324: 116406, 2022 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-36352714

RESUMO

Improving ecosystem quality is the ultimate goal of ecological restoration projects and sustainable ecosystem management. However, previous results of ecosystem quality lack comparability among different regions when assessing the effectiveness of ecological restoration projects on the regional or national scales, due to the influence of geographical and climatic background conditions. Here we proposed a new index, ecosystem quality ratio (EQR), by integrating the status of landscape structure, ecosystem services, ecosystem stability, and human disturbance relative to their reference conditions, and assessed the EQR changes in China's counties and National Key Ecological Function Zones (NKEFZs) from 1990 to 2015. The results showed that the average ecosystem quality of China's counties deviated from the reference condition by 28%. EQR decreased by 1.2% during 1990-2000 but increased by 3.7% during 2000-2015. Those counties with increasing EQR in 2000-2015 occupy 64.7%, with obviously increasing counties mainly located in the water conservation, biodiversity maintenance, and water and soil conservation types of NKEFZs. The EQR increase in counties within NKEFZs was 3.65 times that outside of NKEFZs. Remarkable improvement of ecosystem quality occurred in the forest region in Changbai Mountain, biodiversity and soil conservation region in Wuling Mountains, and hilly and gully region of Loess Plateau, where EQR increases mainly resulted from the conversion of farmland to forest or grassland and consequent increases in ecosystem services and stability. The magnitude of EQR enhancement showed a positive relationship with the increase in forest and grassland coverage in NKEFZs. Our results highlight the important role of ecological restoration projects in improving ecosystem quality in China, and demonstrate the feasibility of the new index (EQR) for the assessment of ecosystem quality in terms of ecosystem management and restoration.


Assuntos
Conservação dos Recursos Naturais , Ecossistema , Humanos , Conservação dos Recursos Naturais/métodos , Biodiversidade , Solo/química , China
5.
Onco Targets Ther ; 15: 1171-1181, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36238133

RESUMO

Purpose: For locally advanced rectal cancer, neoadjuvant concurrent chemoradiotherapy (CCRT) allows tumor downstaging and makes curative radical proctectomy possible. However, we lack a genetic biomarker to predict cancer prognosis or treatment response. We investigated the association between ubiquitin D (UBD) expression and clinical outcomes in rectal cancer patients receiving CCRT. Patients and Methods: We analyzed the genes associated with the protein modification process (GO:0036211) and identified the UBD gene as the most relevant among the top 7 differentially expressed genes associated with CCRT resistance. We collected tissue specimens from 172 rectal cancer patients who had received CCRT followed by a curative proctectomy. We examine the relationship between UBD expression and patient characteristics, pathological findings, and patient survival, such as metastasis-free survival (MeFS) and disease-specific survival. Results: Upregulated UBD expression was associated with lower pre-CCRT tumor T stage (P = 0.009), lower post-CCRT tumor T stage (P < 0.001), lower post-CCRT nodal stage (P < 0.001), less vascular invasion (P = 0.015), and better tumor regression (P < 0.001). Using univariate analysis, we found that high UBD expression was correlated with better disease-free survival (DFS) (P < 0.0001), local recurrence-free survival (LRFS) (P < 0.0001) and MeFS (P < 0.0001). Moreover, multivariate analysis demonstrated that high UBD expression was associated with superior DFS (P < 0.001), LRFS (P = 0.01), and MeFS (P = 0.004). Conclusion: UBD upregulation was linked to better clinical prognosis, favorable pathological features, and good treatment response in rectal cancer patients undergoing CCRT. These results suggest UBD is a biomarker for rectal cancer.

6.
J Environ Manage ; 313: 114944, 2022 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-35381526

RESUMO

Widespread concern about ecological degradation has prompted development of concepts and exploration of methods to quantify ecological quality with the aim of measuring ecosystem changes to contribute to future policy-making. This paper proposes a conceptual framework for ecological quality measurement based on current ecosystem functions and biodiverse habitat, compared with pixel-scale historical baselines. The framework was applied to evaluate the changes and driving factors of ecological quality for Chinese terrestrial ecosystems through remote sensing-based and ecosystem process modeled data at 1 km spatial resolution from 2000 to 2018. The results demonstrated the ecological quality index (EQI) had a very different spatial pattern based upon vegetation distribution. An upward trend in EQI was found over most areas, and variability of 46.95% in EQI can be explained well by change in climate, with an additional 10.64% explained by changing human activities, quantified by population density. This study demonstrated a practical and objective approach for quantifying and assessing ecological quality, which has application potential in ecosystem assessments on scales from local to region and nation, yet would provide a new scientific concept and paradigm for macro ecosystems management and decision-making by governments.


Assuntos
Mudança Climática , Ecossistema , Biodiversidade , China , Atividades Humanas , Humanos
7.
Spectrochim Acta A Mol Biomol Spectrosc ; 273: 121067, 2022 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-35228084

RESUMO

Accurately evaluating the aging state of oil paper insulation in electrical equipment is a key to ensure the safe operation of the power transformer. For achieving highly sensitive in-situ detection of dissolved furfural in transformer oil with good reproducibility, flower-like silver nanoparticles modified with carbon nanotubes (CNTs@Ag-F-AgNPs) was synthesized by a combination of electroless silver plating and redox method. The large specific surface area and strong adsorption capacity of CNTs@Ag promoted the formation of more "hot spots". CNTs@Ag-F-AgNPs were adsorbed on Si-Au substrate via mercapto groups on the coupling agent 1'4 phenyldimercaptan molecule (BDT). Using rhodamine 6G (R6G) as probe molecule, the enhanced factor reached 6.96 × 109. Then, the substrate was used for in-situ SERS detection of transformer oil-dissolved furfural at different concentrations and the detection limit was 2.25 mg/L at 1703 cm-1 (Stretching vibration of C = O in furfural molecule), fulfilling requirements of furfural content detection after severe aging of transformer (4 mg/L). Besides, the relative standard deviation (RSD) of characteristic peak intensity at ten different positions was only 1.74%. These results exhibite that three-dimensional nanostructure with high sensitivity and good reproducibility exhibited a wide application range for in situ detection of dissolved trace furfural in transformer oil.


Assuntos
Nanopartículas Metálicas , Nanotubos de Carbono , Furaldeído , Nanopartículas Metálicas/química , Reprodutibilidade dos Testes , Prata/química , Análise Espectral Raman/métodos
8.
Sci Total Environ ; 822: 153386, 2022 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-35093352

RESUMO

Over the past 50 years, global land surface air temperature has been rising at a much higher rate at night than during the day. Understanding plant responses to the asymmetric daytime and nighttime warming in the context of climate change has been a hot topic in global change biology and global ecology. It has been debatable whether the asymmetric warming has opposite effects on vegetation activity (e.g., phenology, productivity). Here we settle the debate by scrutinizing the underpinnings of different statistical methods and revealing how the misuse or improper use of these methods could mischaracterize the effects of asymmetric warming with in situ and satellite observations. The use of the ordinary least square (OLS) methods including both daytime (Tmax) and nighttime (Tmin) temperature in the multiple regression models could overlook the multicollinearity problem and yield the misinterpretations that Tmax and Tmin had opposite effects on spring phenology, autumn phenology, gross primary production (GPP), and normalized difference vegetation index (NDVI). However, when the OLS methods were applied with Tmax and Tmin included in separate models or alternatively the ridge regression (RR) method with properly selected ridge parameter was used, the effects of Tmax and Tmin on vegetation activity were generally in the same direction. The use of the RR method with improperly selected ridge parameter could also mischaracterize the effects of asymmetric warming. Our findings show that daytime and nighttime warming has no opposite effects on vegetation phenology and productivity in the northern hemisphere, and properly dealing with the multicollinearity problem is critical for understanding the effects of asymmetric warming on vegetation activity.


Assuntos
Mudança Climática , Ecossistema , Plantas , Estações do Ano , Temperatura
9.
Ying Yong Sheng Tai Xue Bao ; 32(8): 2653-2665, 2021 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-34664437

RESUMO

More attention has been paid to the monitoring, assessment, prediction, early warning and sustainable management of regional ecological environment and the changes of ecosystem state in recent years. It is an important scientific and technological task to develop quantitative methods and numerical simulation techniques for ecosystem modelling, and to construct the continental scale numerical simulator with the characteristics of multi-process coupling, multi-technology integration, and multi-objective application for stimulating research on ecosystem and global change and its resources, environment and disaster effects, based on the in-depth understanding of the components, processes, functions, patterns, and their interaction mechanism of terrestrial ecosystem. Here, we reviewed the current status and future direction of terrestrial ecosystem models, and discussed the conceptual framework of developing the simulation system of dynamic change and spatial variation in large-scale terrestrial ecosystems and its resource and environment effect, as well as basic issues on the function orientation and structure design of the simulation system, which would provide reference for constructing Chinese terrestrial ecosystem numerical simulator.


Assuntos
Clima , Ecossistema , Simulação por Computador
10.
Future Oncol ; 17(31): 4145-4156, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34467778

RESUMO

Background: Bioinformatic analysis has revealed that OXR1 is significantly downregulated in muscle-invasive bladder cancer. Patients & methods: The expression of OXR1 in patients with urothelial carcinoma was evaluated by immunohistochemistry, including 340 cases with urothelial carcinoma in the upper urinary tract and 295 in the urinary bladder. Results: Low expression of OXR1 was significantly correlated with adverse pathological parameters including high primary tumor (pT) stage, high node stage, high histological grade, high mitotic activity and increased vascular or perineural invasion (all p < 0.05). Low expression of OXR1 independently predicted worse metastasis-free survival (p = 0.033) in urothelial carcinoma of the upper urinary tract and worse disease-specific survival (p = 0.022) and metastasis-free survival (p < 0.001) in urothelial carcinoma of the urinary bladder. Conclusion: Low expression of OXR1 is an adverse prognostic factor in urothelial carcinoma.


Assuntos
Carcinoma de Células de Transição/mortalidade , Proteínas Mitocondriais/análise , Neoplasias Urológicas/mortalidade , Adulto , Idoso , Carcinoma de Células de Transição/química , Carcinoma de Células de Transição/patologia , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Neoplasias Urológicas/química , Neoplasias Urológicas/patologia
11.
Int J Urol ; 28(11): 1178-1187, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34374132

RESUMO

OBJECTIVE: To examine the expression levels of the glycosyltransferase 8 domain containing protein 2 and its clinical implications in urothelial carcinoma patients. METHODS: Data mining, immunohistochemistry together with H-score calculation was carried out to evaluate the glycosyltransferase 8 domain containing protein 2 levels on tissue specimens from urothelial carcinoma patients, retrospectively. Correlations between glycosyltransferase 8 domain containing protein 2 H-score and imperative clinicopathological factors were measured. The indication of glycosyltransferase 8 domain containing protein 2 level on disease-specific and metastasis-free survivals were next analyzed. RESULTS: In upper tract urothelial carcinomas (n = 340) and bladder urothelial carcinomas (n = 295), 170 (50%) and 148 (50%) patients, respectively, were identified to have high glycosyltransferase 8 domain containing protein 2 expression. The glycosyltransferase 8 domain containing protein 2 levels were correlated to several clinicopathological characteristics and patient survival. Upregulation of the glycosyltransferase 8 domain containing protein 2 was correlated to primary tumor (P < 0.001), nodal metastasis (P < 0.001), histological grade (P < 0.001), vascular invasion (P < 0.001), perineural invasion (P < 0.05) and mitotic rate (P < 0.001). High glycosyltransferase 8 domain containing protein 2 levels independently predicted poor disease-specific survival (P = 0.049) and metastasis-free survival (P = 0.008) in upper tract urothelial carcinoma and urinary bladder urothelial carcinoma, respectively. Gene Ontology enrichment analysis additionally showed that multiple biological processes were enriched including "ECM organization" (Gene Ontology:0030198), "extracellular structure organization" (Gene Ontology:0043062), "biological adhesion" (Gene Ontology:0022610), "cell adhesion" (Gene Ontology:0007155), "collagen fibril organization" (Gene Ontology:0030199) and "vasculature development" (Gene Ontology:0001944). CONCLUSIONS: The present findings suggest that upregulation of the glycosyltransferase 8 domain containing protein 2 is an independent and disadvantageous prognosticator in urothelial carcinoma. High glycosyltransferase 8 domain containing protein 2 level might play a crucial role in progression of urothelial carcinoma.


Assuntos
Carcinoma de Células de Transição , Glicosiltransferases , Neoplasias da Bexiga Urinária , Biomarcadores Tumorais , Glicosiltransferases/genética , Humanos , Prognóstico , Estudos Retrospectivos
12.
Med Mol Morphol ; 54(4): 356-367, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34398348

RESUMO

Data mining on a public domain detected eight potential transcripts which were upregulated in advanced UBUCs, suggesting that they may take part in UC development or/and progression. Retrospectively, immunohistochemistry along with H-score recording was carried out to evaluate the GNB4 protein levels on tissues from UC patients. Correlations between GNB4 H-score and imperative clinicopathological factors, as well as the implication of GNB4 protein level on disease-specific and metastasis-free survivals were assessed. In UTUCs (n = 340) and UBUCs (n = 295), 170 (50.0%) and 148 (50.0%) cases, respectively, were identified to be of high GNB4 expression. The GNB4 protein levels were correlated to numerous clinicopathological features and patients' survivals. Upregulation of the GNB4 protein was significantly associated with primary tumor, nodal metastasis, histological grade, vascular invasion and mitotic rate. High GNB4 protein levels independently and significantly predicted poor disease-specific and metastasis-free in UTUC and UBUC, respectively. Ingenuity pathway analysis furthermore showed that multiple signaling pathways were enriched including 'Communication between Innate and Adaptive Immune Cells' and 'NFκB Signaling'. Our findings demonstrated that the upregulation of the GNB4 protein is an independent unfavorable prognosticator in UC. High GNB4 gene expression plays an important role in UC progression.


Assuntos
Carcinoma de Células de Transição , Subunidades beta da Proteína de Ligação ao GTP/metabolismo , Neoplasias da Bexiga Urinária , Carcinoma de Células de Transição/diagnóstico , Humanos , Imuno-Histoquímica , Subunidades Proteicas , Estudos Retrospectivos , Neoplasias da Bexiga Urinária/diagnóstico
13.
Ying Yong Sheng Tai Xue Bao ; 32(6): 2119-2128, 2021 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-34212618

RESUMO

Evapotranspiration (ET) is a fundamental flux in land surface hydrothermal process. Because of the differences in basic concepts, assumptions, application scales, different models have induced varying uncertainties to the estimation and simulation of evapotranspiration. With the Three-River-Source National Park as an example, we used the Bayesian model averaging (BMA) method to integrate the ET estimations from five models of PT-JPL, ARTS-GIMMS3, ARTS-MODIS, MODIS global evapotranspiration product (MOD16), and SSEBop, and tried to improve the estimating accuracy of evapotranspiration. The results showed that the five models could well capture the seasonal variations in evapotranspiration at Haibei Flux Station, with an explanation range of 64%-86% variability in the observed ET, and a root means square deviation (RMSD) ranged from 0.47 mm·(8 d)-1 to 0.76 mm·(8 d)-1. BMA-based ET greatly improved its explanation to 89% and decreased the RMSD to 0.43 mm·(8 d)-1. The Three-River-Source National Park experienced an overall insignificant increasing trend in its inter-annual ET from 2003 to 2015. At the regional scale, the effects of temperature and precipitation on evapotranspiration were not significant, but were significant in the Yangtze River Source Park. Temperature and precipitation had positive impacts on evapotranspiration. The evapotranspiration showed different trends due to the geographi-cal differences between parks. This study provided a method reference for other multi-source data integration analysis. The integrated evapotranspiration data could effectively reduce the uncertainty of the original models and provide a more accurate data basis for the study of regional water heat change, which is of great significance to better understand water cycle under climate changes.


Assuntos
Parques Recreativos , Rios , Teorema de Bayes , Tecnologia de Sensoriamento Remoto , Ciclo Hidrológico
14.
Curr Oncol ; 28(4): 2373-2384, 2021 06 25.
Artigo em Inglês | MEDLINE | ID: mdl-34202399

RESUMO

BACKGROUND: Patients with rectal cancer can prospectively be favored for neoadjuvant concurrent chemoradiotherapy (CCRT) to downstage before a radical proctectomy, but the risk stratification and clinical outcomes remain disappointing. METHODS: From a published rectal cancer transcriptome dataset (GSE35452), we highlighted extracellular matrix (ECM)-linked genes and identified the serine protease inhibitor Kazal-type 4 (SPINK4) gene as the most relevant among the top 10 differentially expressed genes associated with CCRT resistance. We accumulated the cases of 172 rectal cancer patients who received neoadjuvant CCRT followed by surgery and collected tumor specimens for the evaluation of the expression of SPINK4 using immunohistochemistry. RESULTS: The results revealed that high SPINK4 immunoexpression was significantly related to advanced pre-CCRT and post-CCRT tumor status (both p < 0.001), post-CCRT lymph node metastasis (p = 0.001), more vascular and perineurial invasion (p = 0.015 and p = 0.023), and a lower degree of tumor regression (p = 0.001). In univariate analyses, high SPINK4 immunoexpression was remarkably correlated with worse disease-specific survival (DSS) (p < 0.0001), local recurrence-free survival (LRFS) (p = 0.0017), and metastasis-free survival (MeFS) (p < 0.0001). Furthermore, in multivariate analyses, high SPINK4 immunoexpression remained independently prognostic of inferior DSS and MeFS (p = 0.004 and p = 0.002). CONCLUSION: These results imply that high SPINK4 expression is associated with advanced clinicopathological features and a poor therapeutic response among rectal cancer patients undergoing CCRT, thus validating the prospective prognostic value of SPINK4 for those patients.


Assuntos
Neoplasias Retais , Inibidores de Serina Proteinase , Biomarcadores Tumorais/genética , Quimiorradioterapia , Intervalo Livre de Doença , Humanos , Estudos Prospectivos , Neoplasias Retais/tratamento farmacológico , Neoplasias Retais/terapia , Inibidores de Serinopeptidase do Tipo Kazal , Inibidores de Serina Proteinase/uso terapêutico
15.
Int J Clin Oncol ; 26(9): 1689-1697, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34043102

RESUMO

BACKGROUND: Rectal cancer patients can conceivably obtain relief from neoadjuvant concurrent chemoradiotherapy (CCRT) for downstaging before resection, but the stratification of risk and clinical outcomes remains challenging. Therefore, identifying effective predictive biomarkers offers clinicians the opportunity to individually tailor early interventions, which would help optimize therapy. METHODS: Using a public rectal cancer transcriptome dataset (GSE35452), we focused on cytoskeletal protein binding (GO: 0008092)-related genes and identified FERM domain containing 3 (FRMD3) as the most significant differentially expressed gene associated with CCRT resistance. We gathered 172 tumor samples from rectal cancer patients treated with neoadjuvant CCRT accompanied by curative resection and estimated the expression level of FRMD3 using immunohistochemistry. RESULTS: The results revealed that high FRMD3 immunoexpression was remarkably associated with advanced pre-CCRT and post-CCRT tumor status (p = 0.004 and p < 0.001), pre-CCRT and post-CCRT lymph node metastasis (both p < 0.001), more perineurial invasion (p = 0.023), and a smaller extent of tumor regression (p = 0.018). High FRMD3 immunoexpression was remarkably correlated with inferior disease-specific survival (DSS) (p = 0.0001), local recurrence-free survival (LRFS) (p = 0.0003), and metastasis-free survival (MeFS) (p = 0.0023) at the univariate level. Furthermore, in multivariate analysis, high FRMD3 immunoexpression remained independently predictive of inferior DSS (p = 0.002), LRFS (p = 0.005), and MeFS (p = 0.015). CONCLUSION: These results suggest that high FRMD3 expression is related to advanced clinicopathological features and inferior therapeutic responses in rectal cancer patients treated with CCRT, validating the promising prognostic value of FRMD3 expression.

16.
Case Rep Oncol ; 14(1): 232-238, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33776709

RESUMO

Anti-epithelial growth factor receptor or anti-vascular endothelial growth factor agents combined with chemotherapy were the standard of treatment for metastatic colorectal cancer (CRC). However, increasing evidence of molecularly stratified treatment makes the complexity of treatment. Anaplastic lymphoma kinase (ALK) gene alternation is one of potential target for biomarker-guided therapy for CRC. We present a case of a 56-year-old man who suffered from advanced ascending colon cancer, harboring echinoderm microtubule associated protein-like 4 (EML4)-ALK fusion gene E21; A20 variant, a rare variant in EML4-ALK fusion gene in lung cancer. We also detected this fusion gene from different tissue types including circulating tumor DNA (ctDNA) and ascites fluid. The patient was offered alectinib, an ALK inhibitor, with partial response in lung, liver, and peritoneal metastasis for 8 months. Tumor heterogeneity, especially in gastrointestinal tract cancer, raise our interest in comprehensive genetic profiling in clinical practice. Convenience and reliability of next-generation sequencing, including using ctDNA, help physicians deal with clinical dilemma. ALK-positive CRC is rare. However, advanced CRC with ALK gene alteration responds to ALK inhibitor. It is reasonable to check ALK gene alteration in clinical practice for CRC.

17.
Sci Data ; 8(1): 42, 2021 02 02.
Artigo em Inglês | MEDLINE | ID: mdl-33531507

RESUMO

Chinese forests cover most of the representative forest types in the Northern Hemisphere and function as a large carbon (C) sink in the global C cycle. The availability of long-term C dynamics observations is key to evaluating and understanding C sequestration of these forests. The Chinese Ecosystem Research Network has conducted normalized and systematic monitoring of the soil-biology-atmosphere-water cycle in Chinese forests since 2000. For the first time, a reference dataset of the decadal C cycle dynamics was produced for 10 typical Chinese forests after strict quality control, including biomass, leaf area index, litterfall, soil organic C, and the corresponding meteorological data. Based on these basic but time-discrete C-cycle elements, an assimilated dataset of key C cycle parameters and time-continuous C sequestration functions was generated via model-data fusion, including C allocation, turnover, and soil, vegetation, and ecosystem C storage. These reference data could be used as a benchmark for model development, evaluation and C cycle research under global climate change for typical forests in the Northern Hemisphere.


Assuntos
Ciclo do Carbono , Monitoramento Ambiental , Florestas , Atmosfera , Biomassa , Carbono/análise , China , Solo
18.
PLoS One ; 16(1): e0244159, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33400695

RESUMO

The application of reclaimed asphalt pavement has been widely encouraged due to its significant economic and environmental benefits. However, it is necessary to add rejuvenators to ensure its performance. Currently, bio-oil-based regenerants have attracted attention owing to their advantages of renewability and cost savings. The purpose of this paper is to study the use of recycled vegetable oil waste (R-oil) and recycled polyethylene particles for the regeneration and modification of aged asphalt. Physical, rheological, and chemical tests were used to figure out their influence on the pavement performance of aged asphalt. According to the physical test indices (penetration, softening point, and ductility), the performance of the rejuvenated asphalt was better than that of virgin asphalt. The workability and low-temperature performance of the rejuvenated asphalt were basically the same as those of virgin asphalt, and its fatigue and high-temperature performance were better. Infrared spectroscopy showed that R-oil diluted the high-polarity sulfoxide base of aged asphalt. Gel permeation chromatography showed that its molecular weight dispersion was better than that of aged asphalt. Therefore, R-oil and polyethylene can improve the pavement performance and chemical properties of aged asphalt.


Assuntos
Materiais de Construção/análise , Hidrocarbonetos/química , Óleos de Plantas/química , Polietileno/química , Cromatografia em Gel , Temperatura Baixa , Estudos de Viabilidade , Peso Molecular , Reciclagem , Safrol/análogos & derivados , Safrol/análise , Fatores de Tempo
19.
Sci Data ; 7(1): 369, 2020 10 27.
Artigo em Inglês | MEDLINE | ID: mdl-33110108

RESUMO

The ratio of plant transpiration to total terrestrial evapotranspiration (T/ET) captures the role of vegetation in surface-atmosphere interactions. However, several studies have documented a large variability in T/ET. In this paper, we present a new T/ET dataset (also including transpiration, evapotranspiration data) for China from 1981 to 2015 with spatial and temporal resolutions of 0.05° and 8 days, respectively. The T/ET dataset is based on a model-data fusion method that integrates the Priestley-Taylor Jet Propulsion Laboratory (PT-JPL) model with multivariate observational datasets (transpiration and evapotranspiration). The dataset is driven by satellite-based leaf area index (LAI) data from GLASS and GLOBMAP, and climate data from the Chinese Ecosystem Research Network (CERN). Observational annual T/ET were used to validate the model, with R2 and RMSE values were 0.73 and 0.07 (12.41%), respectively. The dataset provides significant insight into T/ET and its changes over the Chinese terrestrial ecosystem and will be beneficial for understanding the hydrological cycle and energy budgets between the land and the atmosphere.


Assuntos
Transpiração Vegetal , China , Clima , Ecossistema , Análise Espaço-Temporal
20.
J Environ Manage ; 250: 109403, 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31499466

RESUMO

The world is experiencing serious soil losses. Soil erosion has become an important environmental problem in certain regions and is strongly affected by climate and land use changes. By selecting and reviewing 13 extensively used soil water erosion models (SWEMs) from the published literature, we summarize the current model-based knowledge on how climate factors (e.g., rainfall, freeze-thaw cycles, rainstorms, temperature and atmospheric CO2 concentrations) and land use change impact soil erosion worldwide. This study also provides a critical review of the application of these 13 SWEMs. By comparing model structures, features, prediction accuracies, and erosion processes, we recommend the most suitable SWEMs for different regions of the globe (Asia, Europe, Africa and the America) based on the evaluations of 13 SWEMs. Future soil erosion could be simulated using the RUSLE, LISEM, WEPP v2010.1, SWAT, EPIC, KINEROS and AGNPS models in Asia; the RUSLE, WEPP v2010.1, SWAT, EPIC, WATEM-SEDEM, MEFIDIS, AGNPS and AnnAGNPS models in Europe; the RUSLE, LISEM, SWAT, and AGNPS models in Africa; and the WEPP v2010.1, SWAT, EPIC, KINEROS, AGNPS and AnnAGNPS models in America. Finally, the limitations and challenges of the 13 SWEMs are highlighted.


Assuntos
Solo , Água , África , Ásia , Clima , Europa (Continente)
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