RESUMO
Despite the importance of haemodynamic management in patients undergoing liver transplantation, there is currently no consensus on the most appropriate type of monitoring to use. In this context, transoesophageal echocardiography can provide useful information to professionals, although their use constraints prevent further spread today.
Assuntos
Ecocardiografia Transesofagiana , Transplante de Fígado/métodos , Monitorização Intraoperatória/métodos , Determinação do Volume Sanguíneo , Cateterismo de Swan-Ganz , Contraindicações de Procedimentos , Forame Oval Patente/diagnóstico por imagem , Hemodinâmica , Síndrome Hepatopulmonar/diagnóstico por imagem , Humanos , Hipertensão Portal/diagnóstico por imagem , Hipertensão Pulmonar/diagnóstico por imagem , Complicações Intraoperatórias/diagnóstico por imagem , Estudos Multicêntricos como Assunto , Embolia Pulmonar/diagnóstico por imagem , Análise de Onda de PulsoAssuntos
Aneurisma da Aorta Torácica/cirurgia , Complicações Pós-Operatórias/terapia , Isquemia do Cordão Espinal/etiologia , Isquemia do Cordão Espinal/terapia , Idoso , Implante de Prótese Vascular , Procedimentos Endovasculares , Humanos , Masculino , Paraplegia/etiologia , Paraplegia/terapia , Complicações Pós-Operatórias/diagnóstico por imagem , Isquemia do Cordão Espinal/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
Familial amyloid polyneuropathy (FAP) is a systemic amyloidosis caused by mutated transthyretin. Cardiac amyloidosis, the major prognostic determinant in systemic amyloidosis, is characterized by infiltration of the myocardium, leading to cardiomyopathy and conduction disturbances. Liver transplantation is the only curative option for patients with FAP. The case is presented of a 36-year-old patient with type i FAP with cardiac involvement, proposed for liver transplant surgery, which was successfully performed without any preoperative event of interest.
Assuntos
Neuropatias Amiloides Familiares/complicações , Cardiomiopatias/etiologia , Transplante de Fígado/métodos , Assistência Perioperatória/métodos , Adulto , Bloqueio Atrioventricular/diagnóstico por imagem , Bloqueio Atrioventricular/etiologia , Cardiomiopatias/diagnóstico por imagem , Humanos , Complicações Intraoperatórias/prevenção & controle , Masculino , Monitorização Intraoperatória , Norepinefrina/uso terapêutico , Complicações Pós-Operatórias/prevenção & controle , Resistência Vascular/efeitos dos fármacosAssuntos
Analgesia Epidural/métodos , Transplante de Rim , Dor Pós-Operatória/prevenção & controle , Anestesia Epidural/métodos , Anestesia Geral , Terapia Combinada , Contraindicações , Feminino , Doença de Hodgkin/complicações , Doença de Hodgkin/terapia , Humanos , Falência Renal Crônica/etiologia , Falência Renal Crônica/cirurgia , Doença Pulmonar Obstrutiva Crônica/diagnóstico , Doença Pulmonar Obstrutiva Crônica/etiologia , Testes de Função Respiratória , Adulto JovemAssuntos
Extubação , Complicações Intraoperatórias/etiologia , Intubação Intratraqueal/métodos , Laringoscópios , Disostose Mandibulofacial/complicações , Adolescente , Obstrução das Vias Respiratórias/etiologia , Anestesia por Inalação , Desenho de Equipamento , Feminino , Humanos , Intubação Intratraqueal/instrumentação , Curva de Aprendizado , Mandíbula/cirurgia , Gravação em Vídeo/instrumentaçãoAssuntos
Queimaduras por Corrente Elétrica/complicações , Miíase/etiologia , Couro Cabeludo/lesões , Infecção dos Ferimentos/parasitologia , Antibacterianos/uso terapêutico , Desbridamento , Dependência de Heroína/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Miíase/cirurgia , Couro Cabeludo/cirurgia , Transplante de Pele , Retalhos CirúrgicosAssuntos
Aneurisma da Aorta Torácica/cirurgia , Doenças da Aorta/etiologia , Dissecção Aórtica/cirurgia , Implante de Prótese Vascular/métodos , Fístula Brônquica/etiologia , Procedimentos Endovasculares/efeitos adversos , Fístula Esofágica/etiologia , Fístula Vascular/etiologia , Adulto , Transfusão de Componentes Sanguíneos , Implante de Prótese Vascular/efeitos adversos , Síndromes Compartimentais/etiologia , Síndromes Compartimentais/cirurgia , Evolução Fatal , Humanos , Masculino , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Hemorragia Pós-Operatória/etiologia , Hemorragia Pós-Operatória/terapiaRESUMO
Thyroid ophthalmopathy is a rare extra-thyroid complication usually associated with Graves' disease. This disease can occur in the euthyroid pregnant patient. Graves' orbitopathy is characterized by eyelid retraction, proptosis, extraocular muscle dysfunction, and periorbital edema. In some cases an emergency surgical repair may be required to avoid irreversible vision loss. We present the case of a 35-year-old woman in her 30th gestational week, who suffered from Graves' ophthalmopathy, severe exophthalmia, and visual acuity decrease. Following consultations among anesthesiologists, ophthalmologists, maxillofacial surgeons, endocrinologists, obstetricians and the patient, it was decided to perform a surgical orbital wall decompression. The anesthetic and perioperative implications associated with gestational age and the considerations for this surgical procedure, and how to avoid increasing intraocular pressure are discussed.
Assuntos
Anestesia Geral/métodos , Descompressão Cirúrgica , Oftalmopatia de Graves/cirurgia , Assistência Perioperatória/métodos , Complicações na Gravidez/cirurgia , Adulto , Antibioticoprofilaxia , Emergências , Exoftalmia/etiologia , Exoftalmia/cirurgia , Feminino , Oftalmopatia de Graves/diagnóstico por imagem , Humanos , Órbita/cirurgia , Medicação Pré-Anestésica , Gravidez , Complicações na Gravidez/diagnóstico por imagem , RadiografiaAssuntos
Neuralgia/terapia , Dor Intratável/terapia , Complicações Pós-Operatórias/terapia , Estimulação da Medula Espinal/métodos , Espondilolistese/complicações , Adulto , Transplante Ósseo , Terapia Combinada , Humanos , Fixadores Internos , Vértebras Lombares/anormalidades , Masculino , Entorpecentes/uso terapêutico , Neuralgia/tratamento farmacológico , Neuralgia/etiologia , Dor Intratável/tratamento farmacológico , Dor Intratável/etiologia , Complicações Pós-Operatórias/tratamento farmacológico , Complicações Pós-Operatórias/etiologia , Pseudoartrose/etiologia , Reoperação , Sacro/anormalidades , Espondilolistese/congênito , Espondilolistese/cirurgiaAssuntos
Imageamento por Ressonância Magnética , Neoplasias Meníngeas/patologia , Meningioma/patologia , Idoso , Anestesia Intravenosa , Transfusão de Sangue , Edema Encefálico/prevenção & controle , Humanos , Complicações Intraoperatórias/prevenção & controle , Masculino , Neoplasias Meníngeas/cirurgia , Meningioma/cirurgia , Monitorização IntraoperatóriaRESUMO
The effect of oral administration of three different nematode-trapping fungi, in aqueous suspension containing either Dactylaria sp. or Arthrobotrys oligospora conidia or Duddingtonia flagrans chlamydospores, on the number of Haemonchus contortus infective larvae in sheep faeces, was evaluated. The three selected species of fungi produce three-dimensional adhesive nets in the presence of nematodes. Sixteen Creole sheep were divided into four groups of four animals each. Groups 1 and 2 were orally drenched with a suspension containing 2x10(7) conidia of either A. oligospora or Dactylaria sp. Group 3, received a similar treatment, with D. flagrans chlamydospores, instead of conidia, being administered, at the same dose. Group 4 acted as control, without any fungi. Faecal samples were collected directly from the rectum of each sheep and faecal cultures were prepared and incubated at 15 and 21 days. Larvae were recovered from faecal cultures and counted. The highest reduction of the nematode population occurred in the D. flagrans group, reaching reductions of 96.3% and 91.4% in individual samplings in plates incubated for 15 and 21 days, respectively. Arthrobotrys oligospora showed moderate reductions in the faecal larval population, ranging between 25-64% at 15 days incubation. In general, Dactylaria sp., was less efficient in its trapping ability. Despite the inconsistent results with Dactylaria sp., reduction percentages of 73.4% and 80.7% were recorded in individual samplings during the first and second days, in plates incubated for 15 days. Duddingtonia flagrans, was shown to be a potential biological control agent of H. contortus infective larvae.
Assuntos
Fungos/fisiologia , Hemoncose/terapia , Hemoncose/veterinária , Controle Biológico de Vetores/métodos , Doenças dos Ovinos/terapia , Animais , Fezes/parasitologia , Feminino , Hemoncose/microbiologia , Haemonchus/isolamento & purificação , Larva , Masculino , Doenças dos Ovinos/microbiologia , Doenças dos Ovinos/parasitologia , Carneiro DomésticoRESUMO
The aim of this study was to evaluate the predacious capacity in vitro of eight isolates of nematophagous fungi: four of Arthrobotrys sp., one of Arthrobotrys oligospora, one of Duddingtonia flagrans, one of Dactylaria sp. and one Monacrosporium eudermatum. Nine groups of Petri dishes with 13 repetitions each were set up. The fungi were seeded in fluor-corn-agar media, following this each Petri dish was added with 150 larvae of the free living nematode Panagrellus redivivus. Five days after larval addition these were collected by Baermannization and were quantified. A significant difference (p < 0.05) between all treated group was observed respect with the control. Isolates FTHO-8 D. flagrans, R6 M. eudermatum, DAC Dactylaria sp. as well as FTHO-4 and FTHO-6 Arthrobotrys sp., showed an excellent predatory activity (> 90%) and they could be considered as potential bio-control agents in future field trials.
Assuntos
Fungos/fisiologia , Nematoides , Controle Biológico de Vetores , Animais , Bovinos , Doenças dos Bovinos/parasitologia , Doenças dos Bovinos/prevenção & controle , Estudos de Avaliação como Assunto , Larva , Nematoides/crescimento & desenvolvimento , Infecções por Nematoides/parasitologia , Infecções por Nematoides/prevenção & controle , Infecções por Nematoides/veterinária , Especificidade da EspécieRESUMO
One trial was carried out to evaluate the nematophagous capacity of two Duddingtonia flagrans cultures, one maintained during one year at laboratory temperature and the other one was a recent culture, twelve Petri dishes with flour-corn-agar media were seeded with the 1YC another 12 Petri dishes were inoculated with the RC. Both were added with 150 larvae/dish of the free living nematode Panagrellus redivivus and 12 fluor-corn-agar dishes only with the free living nematode were used as a control. The results showed that the nematophagous capacity of both cultures were similar but it was statistically different (p < 0.05) with respect to the control group. It was concluded that the nematophagous capacity of D. flagrans was not affected in spite of being kept one year at laboratory temperature.
Assuntos
Fungos/fisiologia , Nematoides , Controle Biológico de Vetores , Preservação Biológica , Animais , Meios de Cultura , Larva , Nematoides/crescimento & desenvolvimento , TemperaturaRESUMO
A single oral dose of an aqueous suspension containing 11,350,000 chlamydospores of a Mexican isolate of Duddingtonia flagrans (FTHO-8) given to sheep, resulted in a maximum reduction of 88% (range 86.7-90.4%) of the population of Haemonchus contortus infective larvae in the faeces. The effect of this treatment continued for 4-5 days after administration of the suspension. The possible use of this treatment as a method of control of ovine haemonchosis is discussed.
Assuntos
Fungos , Hemoncose/terapia , Hemoncose/veterinária , Controle Biológico de Vetores/métodos , Doenças dos Ovinos/parasitologia , Administração Oral , Animais , Fezes/parasitologia , Feminino , Haemonchus/isolamento & purificação , Masculino , Ovinos , Doenças dos Ovinos/terapiaRESUMO
Culture of human hematopoietic progenitors on a large scale could lead to several clinical applications within the near future, including the production of differentiated and functional cells, the increase in the number of early progenitors, especially stem cells, with such use as gene transfer, or the improvement of grafts used to limit the hematological toxicity associated with high-dose chemotherapy. In this case, one can still distinguish different objectives: improvement of grafts that contain low numbers of progenitors because of prior chemotherapies or because of marrow involvement for example, and qualitative changes in the graft content that would allow to envision the disappearance, or the further reduction, in the duration of absolute neutropenia that follows delivery of high dose chemotherapy ("nadir rescue"), despite substitution of mobilized blood cells to marrow cells and the in vivo use of hematopoietic growth factors. Additional advantages may be related to tumor purging in autologous expanded cells, and to the change in the ratio between hematopoietic progenitors and immunocompetent cells in allogeneic expanded populations. Therefore it appears that in vitro expansion currently raises two types of questions: the first ones are related to the definition of clinical or biological endpoints to be achieved, the second ones are related to "bioengineering", and deal with the efficiency and safety of progenitor cell cultures to be used for clinical applications. We here present preliminary results preparing future pilot clinical studies with ex vivo cultured human hematopoietic cells.
Assuntos
Antígenos CD/sangue , Células-Tronco Hematopoéticas/efeitos dos fármacos , Diferenciação Celular/imunologia , Células Cultivadas , Criopreservação , Citocinas/farmacologia , Células-Tronco Hematopoéticas/imunologia , Humanos , Imunofenotipagem , Monócitos/imunologia , Neutrófilos/imunologia , Projetos PilotoRESUMO
In an in vitro trial, the effect of the nematode-destroying fungus Arthrobotrys robusta on Haemonchus contortus infective larvae was evaluated in petri dishes containing corn meal agar. After seven days incubation at 25 degrees C, 92.33% (+/- 4.1) predation was recorded.
Assuntos
Haemonchus/fisiologia , Fungos Mitospóricos/fisiologia , Animais , Hemoncose/terapia , Hemoncose/veterinária , Haemonchus/ultraestrutura , Larva/fisiologia , Larva/ultraestrutura , Microscopia Eletrônica de Varredura , Fungos Mitospóricos/crescimento & desenvolvimento , Fungos Mitospóricos/ultraestrutura , Ruminantes/parasitologiaRESUMO
Anthelmintic efficacy of ivermectin against Mecistocirrus digitatus was evaluated in 10 naturally infected zebu calves. Group 1 (n = 5) was not treated, and group 2 (n = 5) was treated SC with 200 micrograms of ivermectin/kg of body weight. Calves were euthanatized 14 or 15 days after treatment. There was 100% overall reduction of M digitatus in treated calves, which was significant (P = 0.0079) compared with reduction in controls. Cooperia punctata, Haemonchus similis, and Trichostrongylus axei were found in controls. Efficacy against these parasites in treated calves was 100%.