RESUMO
BACKGROUND AND OBJECTIVE: Therapeutic inertia (TI) is the lack of initiation or intensification of treatment when indicated. It contributes to the fact that more than a third of people with type 2 diabetes mellitus (T2D) do not have adequate metabolic control. We set out to analyze the impact of TI during 4 years of follow-up in a cohort of T2D and its possible variables. MATERIALS AND METHODS: Prospective cohort study of a cohort of 297 TD2 patients. We considered TI when treatment was not modified during the 4 years, despite poor control. We contemplate uncontrolled those that did not meet their individualized HbA1c target. RESULTS: Uncontrolled patients: 87; age: 62.2⯱â¯9.2; 58.7% men. We consider TI in 41.6% of the patients. Average HbA1c 8.22% in patients with treatment intensification of which 43.1% achieved their HbA1c goal, 29.8% were on monotherapy at the beginning, 29.8% double, 36.2% triple and 2,1% in quadruple therapy. There was more change in treatment in people with obesity (67.6 vs. 34.6%; Pâ¯<â¯0.01) and the 6 of the study patients with cardiovascular events (Pâ¯<â¯0.05). Metformin was part of the treatment in 97.1% of IT cases (vs. 76.6%; Pâ¯<â¯0.01). Achievement of the HbA1c target was higher in patients receiving iSGLT2 (0 vs. 68.4%; Pâ¯<â¯0.001). CONCLUSIONS: In 2 out of 5 uncontrolled T2D patients, the treatment was not changed; this was more evident in those patients treated with metformin. Patients with obesity and presence of cardiovascular events seem to protect against IT. Those who were on iSGLT2 have an advantage in meeting their HbA1c target.
Assuntos
Doenças Cardiovasculares , Diabetes Mellitus Tipo 2 , Metformina , Idoso , Glicemia/metabolismo , Estudos de Coortes , Diabetes Mellitus Tipo 2/tratamento farmacológico , Feminino , Hemoglobinas Glicadas/análise , Controle Glicêmico , Humanos , Hipoglicemiantes/uso terapêutico , Masculino , Metformina/uso terapêutico , Pessoa de Meia-Idade , Obesidade/complicações , Estudos ProspectivosRESUMO
BACKGROUND AND OBJECTIVE: Cardiovascular disease is one of the main complications of people with type 2 diabetes (T2D). The ESC/ESA 2019 lipid guide has led to a change in dyslipidemia control. We analyze the evolution of the lipid profile, the fulfillment of the low-density cholesterol (LDL-C) targets, how patients are classified and the impact of this guide on lipid control in T2D patients. MATERIALS AND METHODS: A prospective cohort study from 2017 to 2020 from a cohort of 297 T2D out of a total of 1229 (95% confidence level). We classified patients according to their cardiovascular risk and whether they met or not their LDL-C goal. RESULTS: Age 62.58±10.68 years; 52.79% men. Mean LDL-C levels 116.2 at baseline and 100.2mg/dL at 4 years (P<.001). They met their individualized LDL-C target after publication of the guide: 57 (21.67%). There were more controls who were under 65 years (57.9 vs. 36.9%; P<.01; RR 0.83), men (66.7 vs. 49.5%; P<.05; RR 0.86) and smokers (17.5 vs. 7.8%; P<.05). A percentage of 74.23 had a high cardiovascular risk and a target LDL-C<70mg/dL. CONCLUSIONS: Since the publication of the ESC/ESA 2019 lipid guide, a decrease in LDL-C levels has been observed. Only one in 5 patients fulfill their individualized LDL-C target. Male patients, under 65 years of age and smokers presented an advantage in meeting their goal. Most T2D patients have a high cardiovascular risk, and the predominant LDL-C target is less than 70mg/dL.
Assuntos
Doenças Cardiovasculares , Diabetes Mellitus Tipo 2 , Dislipidemias , Inibidores de Hidroximetilglutaril-CoA Redutases , Idoso , Doenças Cardiovasculares/complicações , Doenças Cardiovasculares/prevenção & controle , Diabetes Mellitus Tipo 2/complicações , Dislipidemias/complicações , Dislipidemias/epidemiologia , Feminino , Humanos , Lipídeos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de RiscoRESUMO
Introducción: Solo el 60 por ciento de los pacientes en tratamiento con antagonistas de la vitamina K (AVK) están controlados. Objetivos: A nalizar una cohorte de pacientes anticoagulados para valorar su grado de control y su evolución a los 2 años, tras una intervención formativa breve. Métodos: Estudio longitudinal, observacional, retrospectivo de 157 anticoagulados con AVK. Se recogieron datos sociodemográficos, comorbilidades, motivo de prescripción del AVK y grado de control basal y tras 2 años de seguimiento. Utilizamos 2 métodos de valoración diferentes: Rosendaal y método directo (porcentaje de INR-Razón Normalizada Internacional- en rango). Asimismo, establecimos correlaciones temporales intramétodo. Resultados: El grado de control pasó del 47,3 por ciento al 53,5 por ciento a los 2 años, según Rosendaal (p= 0,52), y del 39,5 por ciento al 53,5 por ciento según el método directo (p< 0,05). El tiempo en rango terapéutico fue del 63,1 ±19,9 por ciento al inicio y 65 ±19,2 por ciento al final del seguimiento. La correlación entre los 2 controles fue positiva para ambos métodos (Rosendaal: 0,23; método directo: 0,33). El análisis multivariante fue significativo para el sexo masculino y para un objetivo diferente de 2,5-3,5 (odds ratio: 2,22 y 2,73, respectivamente). Conclusiones: El control del INR mejoró a los 2 años de seguimiento tras la actividad formativa. La evolución del grado de control de cada paciente es parcialmente predecible. El peor control se asoció al sexo femenino y al objetivo de INR de 2,5-3,5. El control mejora 2,22 veces en los varones y 2,73 veces en quienes no tienen un INR objetivo de 2,5-3,5(AU)
Introduction: Only 60 percent of patients on treatment with vitamin K antagonists (AVK) are controlled. Objectives: We proposed to analyze a cohort of anticoagulated patients to assess their degree of control and their evolution at 2 years, after a brief training intervention. Methods: Longitudinal, observational, retrospective study of 157 anticoagulated with AVK. Sociodemographic data, comorbidities, reason for VKA prescription and degree of baseline control were collected and after 2 years of follow-up. We use 2 different valuation methods: Rosendaal and direct method (INR percentage -International Normalized Ratio- in range). Likewise, we established intra-method temporal correlations. Results: The degree of control went from 47.3 percent to 53.5 percent at 2 years, according to Rosendaal (p = 0.52), and from 39.5 percent to 53.5 percent according to the direct method (p<0.05). The time in the therapeutic range was 63.1±19.9 percent at the start and 65±19.2 percent at the end of the follow-up. The correlation between the 2 controls was positive for both methods (Rosendaal: 0.23; direct method:0.33). The multivariate analysis was significant for males and for a target other than 2.5-3.5(odds ratio: 2.22 and 2.73, respectively). Conclusions: INR control improved after 2 years of follow-up after training activity. The evolution of the degree of control of each patient is partially predictable. The worst control was associated with female sex and the INR goal of 2.5-3.5. Control improves 2.22 times in males and 2.73 times in those without a target INR of 2.5-3.5(AU)
Assuntos
Humanos , Masculino , Feminino , Coeficiente Internacional Normatizado , Estudos Retrospectivos , Estudos de Coortes , Estudos LongitudinaisRESUMO
INTRODUCTION AND OBJECTIVES: The use of anticoagulants to prevent embolic events in Spain is very high, tending to a progressive increase. For this reason, we intend to analyse the mortality of patients from a metropolitan area of Granada treated with vitamin K antagonist anticoagulants (VKA), over 2 non-consecutive years. PATIENTS AND METHODS: Longitudinal, observational, retrospective study of 205 patients treated with VKA. Sociodemographic data, previous clinical conditions, pathology causing VKA treatment, degree of control and mortality were collected 2 years after the start of the study. RESULTS: Average age, 76±11.8 years (57.56% women). Two-year mortality was 22.4%, with a significant increase depending on age (p<.001) and years of treatment (p<.001). Patients with dementia (p<.05), with chronic kidney disease (p<.01) or with chronic obstructive pulmonary disease (p<.01) also presented higher mortality. Multivariate analysis showed significant effect of chronic kidney disease (odds ratio=4.075), chronic obstructive pulmonary disease (odds ratio=3.694), and years of treatment (odds ratio=1.236). CONCLUSIONS: At 2 years of follow-up, 1 in 5 patients treated with VKA died. The presence of chronic kidney disease, chronic obstructive pulmonary disease and a longer treatment time were independently associated with this increase of mortality. Most of the patients were anticoagulated by atrial fibrillation, they were elderly and had a high prevalence of comorbidities.
Assuntos
Fibrilação Atrial , Acidente Vascular Cerebral , Administração Oral , Idoso , Idoso de 80 Anos ou mais , Anticoagulantes/uso terapêutico , Fibrilação Atrial/complicações , Fibrilação Atrial/tratamento farmacológico , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Atenção Primária à Saúde , Estudos Retrospectivos , Vitamina KRESUMO
OBJECTIVES: To gain greater understanding of the development of emergency medicine in Spain by analyzing the presentations at conferences of the Spanish Society of Emergency Medicine (SEMES) over the past 30 years (1988-2017). MATERIAL AND METHODS: We examined the programs of all SEMES conferences and described the characteristics of both presentations and presenters. We also analyzed changes occurring between 1988 and 2017 of some of the characteristics observed. The Web of Science was searched to evaluate the scientific productivity of the most frequent presenters and to calculate h-indexes for those presenters to assesstheir scientific relevance. RESULTS: SEMES did not hold a conference in 1992. The total of 29 conferences included 2182 presentations (112 listing presenters from abroad) given by 1410 presenters (89 from abroad). The presenters' affiliations named 616 centers. The number of presentations and presenters increased linearly during the first period and then leveled off. The number increased exponentially in the final phase. Men gave 79.6% of the presentations; 70.6% of the presenters were physicians, 11.9% were nurses and 4.0% were ambulance staff. Specialists in emergency medicine accounted for 60.8% of the presenters who were physicians. Presenters from the Spanish autonomous community organizing the conference gave 29.8% of the presentations. The contributions of presenters from the local organizing community were nearly always more numerous than the average number of contributions from that community in all 29 conferences overall. Conference contributions from some autonomous communities (Extremadura, Andalusia, and Catalonia) were considerably fewer than would be expected given the scientific productivity of those communities. However, communities (Murcia, Balearic Islands, Asturias, Castile-Leon, Madrid), gave many more presentations than their productivity metrics would predict. Analysis of the 59 most frequent presenters (at 5 conferences or more) showed that 64.4% of them had published at least 20 articles and that 71.2% had an h-index of 5 or higher. The number of women on the program increased significantly between 1988 and 2017. Likewise, geographic diversity increased significantly (presentations from centers outside the local organizing area) as did the participation of hospitalbased emergency medicine specialists. CONCLUSION: SEMES conference programs have attracted significantly more presentations and presenters over the years. We also detected changes in descriptive characteristics. The analysis of those characteristics can help future SEMES conference planners to plan ways to correct aspects such as scarce geographic diversity, low international participation, and few women among presenters.
OBJETIVO: . Profundizar en el conocimiento y la evolución de la Medicina de Urgencias y Emergencias (MUE) en España a través del análisis de las ponencias presentadas en los congresos de la Sociedad Española de Medicina de Urgencias y Emergencias (SEMES) celebrados los últimos 30 años (1988-2017). METODO: Se revisaron los programas de todos los Congresos SEMES y se analizaron las características de ponencias y ponentes, así como la evolución entre 1988-2017 de algunas de estas características. Se revisó en Web of Science la producción científica y el índice h de los ponentes más frecuentes para contrastar su relevancia científica. RESULTADOS: . En los 29 Congresos SEMES (en 1992 no se celebró) se han presentado 2.182 ponencias (112 internacionales) por 1.410 ponentes (89 internacionales) procedentes de 616 centros. Hubo un crecimiento lineal de ponencias y ponentes los primeros años, una posterior fase de meseta, y finalmente un crecimiento con tendencia exponencial el último lustro. El 79,6% de ponencias fue impartida por hombres, y la distribución de médicos/enfermeros/técnicos fue 70,6%/11,9%/4,0%. Los urgenciólogos realizaron el 60,8% de ponencias médicas. La comunidad autónoma organizadora del congreso aportó el 29,8% de ponencias, casi siempre por encima de lo esperable por su aportación promedio global. Hubo comunidades autónomas cuya participación estuvo muy por debajo de su productividad científica (Extremadura, Andalucía, Cataluña) y otras muy por encima (Murcia, Baleares, Asturias, Castilla-León, Madrid). El 64,4% de los 59 ponentes más asiduos ( 5 congresos) tiene publicados 20 artículos y el 71,2% tiene un índice h 5. Entre 1988-2017 hubo incremento significativo de mujeres ponentes, diversificación geográfica (ponencias de comunidades autónomas no organizadoras del congreso) y urgenciólogos hospitalarios. CONCLUSIONES: Hubo un aumento significativo de ponencias y ponentes en los Congresos SEMES, con cambios detectables en algunas de sus características. El análisis detallado puede permitir intervenciones para corregir algunos aspectos en futuros Congresos SEMES, tales como la escasa diversificación y participación internacional y de mujeres.
Assuntos
Pesquisa Biomédica/tendências , Congressos como Assunto/tendências , Eficiência , Medicina de Emergência/tendências , Sociedades Médicas/tendências , Bibliometria , Feminino , Humanos , Masculino , EspanhaAssuntos
Anticoagulantes/uso terapêutico , Transtornos da Coagulação Sanguínea/tratamento farmacológico , Monitoramento de Medicamentos/métodos , Atenção Primária à Saúde/métodos , Controle de Qualidade , Vitamina K/antagonistas & inibidores , Idoso , Idoso de 80 Anos ou mais , Monitoramento de Medicamentos/normas , Feminino , Humanos , Coeficiente Internacional Normatizado , Masculino , Pessoa de Meia-Idade , Atenção Primária à Saúde/normasRESUMO
OBJECTIVES: To study the publication productivity of Spanish emergency physicians in the 5-year period from 2010 through 2014 and compare it with the previous period (2005-2009). MATERIAL AND METHODS: Articles authored by emergency physicians affiliated with institutions in Spain were selected from the Science Citation Index-Expanded; conference presentations were excluded. We collected data for year of publication, author information, journal, the journal's impact factor (IF), type of article, cites received, and area of research. We searched at 2010-2014 period, and these data were compared with historic data from the 2005-2009 period. RESULTS: A total of 1433 articles were published in 2010-2014; 52.4% were original research articles (56% more than in 2005-2009, P=.01). The mean journal IF associated with the publications was slightly higher in 2010-2014 (2.587 vs 2.483 for 2005-2009). The median was slightly lower (2.295 vs 3.085 in the earlier period), but the 90th percentile was higher (4.036 vs 3.085, P=0.01), reflecting an increase in the number of publications in journals with high IFs. Most articles continue to be published in Castilian Spanish (67.8%), although the percentage of articles published in English increased significantly, from 25.2% in the previous period to 32.1% in 2010-2014; P=.001). Scientific publications in emergency medicine come mainly from specialists working in hospital emergency departments (89%). Authors affiliated with a university are in the minority, although their percentage increased significantly from 10.9% in the previous period to 16.2% in the recent one (P=.001). Collaboration increased in the recent period in all categories: between hospitals in the same Spanish autonomous community (from 24.7% to 36%), in different communities (from 10.9% to 19%), or in different countries (from 2.3% to 8.4%) (P=.001, all comparisons). The most productive research areas were cardiovascular conditions (accounting for 13.1% of the publications), infectious diseases (13.0%), toxicology and pharmacology (9.2%), pediatric emergencies (8.0%), respiratory diseases (7.4%), cardiopulmonary resuscitation (6.7%), and management (6.0%). Catalonia produced the largest number of papers (427 [29.8%]). Hospital Clínic de Barcelona ranked first among hospitals publishing research, with 145 articles (11.4% of the total in this category); the emergency services of Madrid (SUMMA-112) ranked first among out-of-hospital research groups, with 43 publications (36.7% of the total in this category). Catalonia, Madrid, Castile-La Mancha, the Canary Islands, Murcia, the Balearic Islands, and La Rioja increased their contributions to Spanish productivity by 20% or more over their output in the earlier 5-year period. Nine of the 2010-2014 articles have already attracted enough cites to be considered citation classics. CONCLUSION: The productivity of Spanish emergency physicians continued to grow at a good pace in the 2010-2014 period. Publications in journals with IFs increased and there were significant changes in the dynamics of publication and the subjects covered.
OBJETIVO: Estudiar la producción científica de los urgenciólogos españoles durante el quinquenio 2010-2014 y compararla con la del quinquenio anterior (2005-2009). METODO: Se seleccionaron todos los documentos, excluyendo comunicaciones a congresos, firmados por urgenciólogos con filiación española localizados a través de Science Citation Index (SCI)-Expanded. Se recogieron variables sobre año de publicación, autores (número, filiación y orden de firma), revista y factor de impacto (FI), tipo de documento, citas recibidas y áreas de investigación. La búsqueda se realizó para el periodo 2010-2014 y se compararon los datos con datos históricos correspondientes a 2005-2009. RESULTADOS: Durante el quinquenio 2010-2014 se publicaron 1.433 documentos (52,4% artículos originales), un 56% más que en 2005-2009 (p = 0,01). La media de FI fue discretamente superior (2,587 frente a 2,483), la mediana menor (2,295 frente a 3,085), pero con un percentil 90 superior (4,036 frente a 3,085, p = 0,01), lo que muestra un incremento de publicaciones en revistas de alto FI. Los artículos continúan publicándose preferentemente en español-castellano (67,8%) aunque ha incrementado significativamente la producción en inglés (de 25,2% a 32,1%; p = 0,001). La actividad del urgenciólogo investigador es mayoritariamente en servicios de urgencias hospitalarios (SUH) (89%). La filiación universitaria de los autores es baja, aunque ha aumentado significativamente (de 10,9% a 16,2%; p = 0,001). Aumentó la colaboración, tanto con centros de la misma u otra comunidad autónoma (de 24,7% a 36%, y de 10,9% a 19%, respectivamente; p = 0,001 para ambos), como internacional (2,3% a 8,4%; p = 0,001). Las áreas de investigación con más documentos son cardiovascular (13,1%), infecciosas (13,0%), toxicología/farmacología (9,2%), pediatría (8,0%), neumología (7,4%), reanimación cardiopulmonar (6,7%) y organización (6,0%). Cataluña fue la comunidad que más documentos produjo (427; 29,8%). El Hospital Clínic lideró la producción hospitalaria (145, 11,4% de la producción de los SUH) y SUMMA- 112 la extrahospitalaria (43; 36,7% de la producción extrahospitalaria). Cataluña, Madrid, Castilla-La Mancha, Canarias, Murcia, Islas Baleares y La Rioja aumentaron su peso relativo en la producción española un 20% o más respecto al quinquenio previo. Nueve artículos de 2010-2014 ya han alcanzado consideración de clásicos de citación. CONCLUSIONES: La producción científica de los urgenciólogos españoles siguió creciendo a buen ritmo durante el quinquenio 2010-2014, con un incremento de publicaciones en revistas de alto FI, y se aprecian cambios significativos en la dinámica y la temática de investigación.