1.
Bioorg Med Chem Lett
; 19(19): 5746-52, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19726184
RESUMO
Through iterative design cycles we have discovered a number of novel new classes where the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine was deemed the most promising GABA(A) alpha5 inverse agonist class with potential for cognitive enhancement. This class combines a modest subtype binding selectivity with inverse agonism and has the most favourable molecular properties for further lead optimisation towards a central nervous system (CNS) acting medicine.