RESUMO
Perfluoralkyl and polyfluoralkyl substances have been measured in plasma and serum of pregnant women as a measure of prenatal exposure. Increased concentrations of individual perfluoroalkyl acids (PFAAs), (typically perfluorooctanoic acid (PFOA) and perfluoroctane sulfonate (PFOS) have been reported to be associated with reductions in birth weight and other birth outcomes. We undertook a study of 14 PFAAs in whole blood (including PFOS, PFHxS, PFHpA, PFOA, PFNA, PFDA and PFUnDA) from 98 pregnant women in Western Australia from 2008 to 2011. Median concentrations (in µg/L) were: PFOS 1.99; PFHxS 0.33; PFOA 0.86; PFNA 0.30; PFDA 0.12 and PFUnDA 0.08. Infants born to women with the highest tertile of PFHxS exposure had an increased odds of being <95% of their optimal birth weight (OR 3.5, 95% CI 1.1-11.5). Conversely, maternal blood concentrations of PFUnDA were associated with non-significant increases in average birth weight (+102g, 95% CI -41, 245) and significant increases in proportion of optimal birth weight (+4.7%, 95% CI 0.7, 8.8) per ln-unit change. This study has reported a range of PFAAs in the whole blood of pregnant women and suggests that PFHxS and PFUnDA may influence foetal growth and warrant further attention. Additional studies are required to identify the sources of PFAA exposure with a view to prevention, in addition to further studies investigating the long term health effects of these ubiquitous chemicals.
Assuntos
Poluentes Ambientais/sangue , Fluorocarbonos/sangue , Exposição Materna , Adulto , Ácidos Alcanossulfônicos/sangue , Feminino , Humanos , Gravidez , Austrália Ocidental , Adulto JovemRESUMO
Most studies of metals exposure focus on the heavy metals. There are many other metals (the transition, alkali and alkaline earth metals in particular) in common use in electronics, defense industries, emitted via combustion and which are naturally present in the environment, that have received limited attention in terms of human exposure. We analysed samples of whole blood (172), urine (173) and drinking water (172) for antimony, beryllium, bismuth, cesium, gallium, rubidium, silver, strontium, thallium, thorium and vanadium using ICPMS. In general most metals concentrations were low and below the analytical limit of detection with some high concentrations observed. Few factors examined in regression models were shown to influence biological metals concentrations and explained little of the variation. Further study is required to establish the source of metals exposures at the high end of the ranges of concentrations measured and the potential for any adverse health impacts in children.
Assuntos
Poluentes Ambientais/sangue , Poluentes Ambientais/urina , Exposição Materna , Metais/sangue , Metais/urina , Água Potável/análise , Monitoramento Ambiental , Feminino , Humanos , Gravidez/sangue , Gravidez/urina , Austrália OcidentalRESUMO
Environmental exposure to metals has been linked to adverse health outcomes. Exposure to cadmium has been associated with decreased bone density, an increased risk of osteoporotic fracture and possible renal dysfunction. Older women are a group at risk of renal and bone density impacts and exposure to metals may be an important risk factor for these health outcomes. This study was a cross sectional study of 77 women aged 50 years and above examining the relationship between metals exposure and renal and bone health. Urinary and blood metals concentrations, plasma creatinine, iron, ferritin and transferrin were measured in these subjects. Bone biomarkers assessed included the pyridinium crosslinks, pyridinoline and deoxypyridinoline measured by ELISA. Renal function was assessed using eGFR and KIM-1. Whole body, hip and lumbar spine bone mineral density was assessed using DEXA. Blood and urinary metals concentrations were generally low in the subjects, with a median urinary cadmium concentration of 0.26 µg/g creatinine (range <0.065-1.03 µg/g). Urinary cadmium was found to be a significant predictor of bone mineral density at whole body, lumber spine, total hip and femoral neck, with increasing urinary Cd concentrations associated with decreased bone density. Urinary cadmium and aluminium concentrations were positively correlated with bone resorption whilst blood zinc and mercury concentrations were negatively correlated. Urinary aluminium was positively correlated with KIM-1 concentrations, a marker of early kidney damage, however blood zinc concentrations were significantly negatively correlated with this biomarker. This study provides additional support for low cadmium exposure being of concern for the health of older women. Further investigation into the role of exposure to other metals on bone and renal health is warranted.
Assuntos
Densidade Óssea/efeitos dos fármacos , Reabsorção Óssea/etiologia , Cádmio/efeitos adversos , Exposição Ambiental/efeitos adversos , Rim/efeitos dos fármacos , Metais/efeitos adversos , Idoso , Idoso de 80 Anos ou mais , Alumínio/sangue , Alumínio/urina , Biomarcadores/sangue , Biomarcadores/urina , Cádmio/sangue , Cádmio/urina , Creatinina/sangue , Estudos Transversais , Feminino , Taxa de Filtração Glomerular/efeitos dos fármacos , Receptor Celular 1 do Vírus da Hepatite A , Humanos , Rim/metabolismo , Rim/fisiopatologia , Testes de Função Renal , Glicoproteínas de Membrana/sangue , Mercúrio/sangue , Metais/sangue , Metais/urina , Pessoa de Meia-Idade , Receptores Virais/sangue , Zinco/sangueRESUMO
Polychlorinated biphenyls (PCBs) and dioxins are well known for their persistence in the environment. PCBs can be found in the residential environment long after the use of these chemicals in domestic products and industrial processes has ceased. Dioxins have been assessed in Australia as being of very low concentrations. Despite concerns about residential dust as a source of human exposure to persistent chemicals, there has been limited testing of PCBs and dioxins in dust in Australia. As part of an assessment of maternal exposure to a variety of persistent toxic substances, we analysed 30 residential dust samples from a variety of geographical settings for their dioxin and PCB concentrations. PCBs were found in most samples, the median and range concentrations (pg g(-1)) of dominant congeners of PCB were as follows: PCB118 (315; <35.0-29 000), PCB105 (130; 14.0-16 000) and PCB156 (440; <5.00-2800). Dioxin concentrations were generally low with median concentrations for the total sum of dioxin-like polychlorinated dibenzodioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) of 3.75 pg g(-1) each. There was a very high percentage of non-detects. Concentrations of both PCBs and dioxins were low compared with most studies reporting residential dust concentrations internationally. Age of dwelling was the only factor observed to influence both PCB congener concentrations and dioxin isomers in multivariate regression analyses. No other housing or sociodemographic variables, including proximity to industry, were important predictors in multivariate linear regression models.
Assuntos
Poluição do Ar em Ambientes Fechados/análise , Poeira/análise , Bifenilos Policlorados/metabolismo , Poluição do Ar em Ambientes Fechados/estatística & dados numéricos , Austrália , Dioxinas/análise , Feminino , Humanos , Exposição Materna/estatística & dados numéricos , Bifenilos Policlorados/análise , GravidezRESUMO
A variety of metals are important for biological function but have also been shown to impact health at elevated concentrations, whereas others have no known biological function. Pregnant women are a vulnerable population and measures to reduce exposure in this group are important. We undertook a study of maternal exposure to the metals, aluminium, arsenic, copper, cobalt, chromium, lithium, manganese, nickel, selenium, tin, uranium and zinc in 173 participants across Western Australia. Each participant provided a whole blood and urine sample, as well as drinking water, residential soil and dust samples and completed a questionnaire. In general the concentrations of metals in all samples were low with the notable exception of uranium (blood U mean 0.07 µg/L, range <0.01-0.25 µg/L; urinary U mean 0.018 µg/g creatinine, range <0.01-0.199 µg/g creatinine). Factors that influenced biological concentrations were consumption of fish which increased urinary arsenic concentrations, hobbies (including mechanics and welding) which increased blood manganese concentrations and iron/folic acid supplement use which was associated with decreased concentrations of aluminium and nickel in urine and manganese in blood. Environmental concentrations of aluminium, copper and lithium were found to influence biological concentrations, but this was not the case for other environmental metals concentrations. Further work is underway to explore the influence of diet on biological metals concentrations in more detail. The high concentrations of uranium require further investigation.
Assuntos
Exposição Ambiental , Metais/sangue , Metais/urina , Efeitos Tardios da Exposição Pré-Natal , Adulto , Estudos Transversais , Feminino , Humanos , Metais/efeitos adversos , Gravidez , Adulto JovemRESUMO
Recent literature suggests that exposure to low concentrations of heavy metals may affect both maternal and child health. This study aimed to determine the biological heavy metals concentrations of pregnant women as well as environmental and dietary factors that may influence exposure concentrations. One hundred and seventy three pregnant women were recruited from Western Australia, each providing a sample of blood, first morning void urine, residential soil, dust and drinking water samples. Participants also completed a questionnaire which included a food frequency component. All biological and environmental samples were analysed for heavy metals using ICP-MS. Biological and environmental concentrations of lead and mercury were generally low (Median Pb Drinking Water (DW) 0.04 µg/L; Pb soil <3.0 µg/g; Pb dust 16.5 µg/g; Pb blood 3.67 µg/L; Pb urine 0.55; µg/L Hg DW <0.03; Hg soil <1.0 µg/g; Hg dust <1.0 µg/g; Hg blood 0.46 µg/L; Hg urine <0.40 µg/L). Cadmium concentrations were low in environmental samples (Median CdDW 0.02 µg/L; Cdsoil <0.30 ug/g; Cddust <0.30) but elevated in urine samples (Median 0.55 µg/L, creatinine corrected 0.70 µg/g (range <0.2-7.06 µg/g creatinine) compared with other studies of pregnant women. Predictors of increased biological metals concentrations in regression models for blood cadmium were residing in the Great Southern region of Western Australia and not using iron/folic acid supplements and for urinary cadmium was having lower household annual income. However, these factors explained little of the variation in respective biological metals concentrations. The importance of establishing factors that influence low human exposure concentrations is becoming critical in efforts to reduce exposures and hence the potential for adverse health effects.
Assuntos
Exposição Ambiental/estatística & dados numéricos , Metais Pesados/sangue , Metais Pesados/urina , Adulto , Estudos Transversais , Dieta , Feminino , Humanos , Modelos Lineares , Gravidez , Austrália Ocidental , Adulto JovemRESUMO
There are numerous localized peat deposits on the Swan Coastal Plain, an urban and rural bioregion otherwise dominated by wetland ecosystems in southwestern Australia. Hydrological change is significant in the bioregion: urban development encroaches on wetlands, groundwater extraction provides the city population with most of its water, and rainfall declines will not recharge aquifers in the future. The wetland processes which contribute to the formation of these peat deposits have therefore changed and are becoming vulnerable to fire events with residents increasingly exposed to peat smoke. There is an imperative to characterise this peat smoke to determine if exposures are harmful or toxic, and opportunities to do so in this setting arise due to the absence of bushfire smoke which has confounded other international studies. We have measured volatile organic compounds (VOCs) and particulate concentrations from an opportunistic assessment of two peat fires. SUMMA canister grab samples and a portable GCMS were used to determine the VOCs with high 1h benzene concentrations of 16 and 30 ppm v/v. PM10 and PM2.5 particulate data were collected using an Osiris continuous analyser with 24h concentrations recorded at varying time periods (within a 5 months timeframe) ranging from 1h maximums of between 23-37 microgm(-3) for PM10 and 50.5-106 microgm(-3) for PM2.5. While the 24h averages were generally below national air quality standards, elevated 1h concentrations were observed on numerous occasions and on most days. Given the proximity of residential development to many peat deposits, a drying climate and the increased risk of arson in peri-urban environments, the health impacts of exposure to peat smoke need to be determined and if necessary measures developed to prevent exposure (which would include maintaining wetland sediment integrity so as to reduce its vulnerability to fire).
Assuntos
Poluição do Ar/análise , Incêndios , Material Particulado/análise , Solo , Compostos Orgânicos Voláteis/análise , Exposição por InalaçãoRESUMO
A case-crossover study was undertaken to investigate the relationship between daily air pollutant concentrations and daily hospitalizations for selected disease categories in Perth, Western Australia. Daily measurements of particles (measured by nephelometry and PM2.5), photochemical oxidants (measured as ozone), nitrogen dioxide (NO2) and carbon monoxide (CO) concentrations were obtained from 1992 to 1998 via a metropolitan network of monitoring stations. Daily PM2.5 concentrations were estimated using monitored data, modelling and interpolation. Hospital morbidity data for respiratory, cardiovascular (CVD), gastrointestinal (GI) diseases, chronic obstructive pulmonary diseases (COPD) excluding asthma; pneumonia/influenza diseases; and asthma were obtained and categorized into all ages, less than 15 years and greater than 65 years. Gastrointestinal morbidity was used as a control disease. The data were analyzed using conditional logistic regression. The results showed a small number of significant associations for daily changes in particle concentrations, nitrogen dioxide and carbon monoxide for the respiratory diseases, CODP, pneumonia, asthma and CVD hospitalizations. Changes in ozone concentrations were not significantly associated with any disease outcomes. These data provide useful information on the potential health impacts of air pollution in an airshed with very low sulphur dioxide concentrations and lower nitrogen dioxide concentrations commonly found in many other cities.
Assuntos
Poluição do Ar/efeitos adversos , Exposição Ambiental , Hospitalização/estatística & dados numéricos , Poluição do Ar/análise , Asma/induzido quimicamente , Monóxido de Carbono/efeitos adversos , Monóxido de Carbono/análise , Doenças Cardiovasculares/induzido quimicamente , Cidades , Estudos Transversais , Gastroenteropatias/induzido quimicamente , Humanos , Morbidade/tendências , Dióxido de Nitrogênio/efeitos adversos , Dióxido de Nitrogênio/análise , Ozônio/efeitos adversos , Ozônio/análise , Tamanho da Partícula , Análise de Regressão , Transtornos Respiratórios/induzido quimicamente , Doenças Respiratórias/induzido quimicamente , Austrália OcidentalRESUMO
A program of sampling for volatile organic compounds (VOCs) in ambient air was undertaken in selected locations and micro-environments in Perth, Western Australia to characterise concentrations of target VOCs and to determine the relative strength of the contributing sources to ambient air in different micro-environments in a major Australian city. Twenty-seven locations were sampled and, of the forty-one target compounds, 26 VOCs were detected in the samples collected. The highest concentrations were recorded for benzene, toluene, ethylbenzene, xylenes (BTEX), chloroform and styrene. The maximum 12-h toluene and benzene concentrations observed were from a basement carpark and were 24.7 parts per billion (ppb) and 5.6 ppb, respectively. The maximum xylenes concentration was 29.4 ppb and occurred in a nightclub where styrene was also detected. A factor analysis of the data was undertaken. Two key factors emerge that appear to be associated with petroleum and motor vehicles and environmental tobacco smoke. A third significant occurrence was a high concentration of chloroform that was observed at a sports centre complex with a swimming pool text and was uncorrelated with other compounds in the data set. This study indicates that locations associated with motor vehicles and petrol fuel, tobacco and wood smoke and chlorinated water represent the major risks for personal exposure to VOCs in Perth.
Assuntos
Poluentes Atmosféricos/análise , Poluição do Ar em Ambientes Fechados/análise , Compostos Orgânicos/análise , Monitoramento Ambiental , Gasolina , Habitação , Humanos , Exposição Ocupacional/análise , Restaurantes , Fumaça , Nicotiana , Emissões de Veículos , Volatilização , Austrália Ocidental , Madeira , Local de TrabalhoRESUMO
Hazardous air pollutants (HAPS) have been evaluated for their health and environmental significance on a targeted and campaign basis in Australia until recently. Individual States and Territories have been undertaking targeted monitoring studies and have numerous control strategies aimed at controlling HAPS emissions with the focus largely on volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs) and selected heavy metals, with some limited work on exposure assessment. There has been little evaluation of the potential health or environmental effects of the monitored concentrations of these substances and few toxicological or epidemiological studies have been conducted-none in the community setting in Australia. Moreover, there has not been an agreed method for assessing risks from HAPS in ambient air, with different jurisdictions utilising different international benchmarks. Recently, the National Environmental Health (EnHealth) Council commenced developing a risk assessment methodology, which is being used in the development of ambient air quality guidelines for selected HAPS in Western Australia. In 1999, the Commonwealth Government established the Living Cities-Toxics Program, designed to assess the state of knowledge on HAPS in Australia with the aims of identifying and prioritising HAPS, identifying information gaps and informing the development of national air quality standards and national management strategies. The Commonwealth Government commenced a number of projects in 2000 to progress these aims.