How is insulin-like growth factor-1 correlated with retinopathy of prematurity?

BACKGROUND: Evaluation of insulin-like growth factor-1 (IGF-1) association with retinopathy of prematurity (ROP) is our object. MATERIALS AND METHODS: This study was conducted on IGF-1 levels of 40 neonates <34 weeks gestational age and 2000 g at 1st week and 4-6 weeks after birth. All participants were evaluated for ROP after 31 weeks of gestation. RESULTS: IGF-1 levels showed a significant difference between neonates ≤1500 and 1500-2000 g (1 and 4-6 weeks, P = 0.008, P = 0.039, respectively). No significant association was found between IGF-1 and ROP. CONCLUSION: Finding a meaningful association between IGF-1 and ROP requires consideration of factors affecting the IGF-1.