Association among cardiopulmonary and metabolic rehabilitation, arrhythmias, and myocardial ischemia responses of patients with HFpEF or HFmrEF.

There's limited evidence of the potential benefits of cardiopulmonary and metabolic rehabilitation (CPMR) in patients with heart failure with preserved ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF) and coronary artery disease (CAD). The aim of this study was to investigate the impact of CPMR on the myocardial ischemia response (MIR), exercise-induced arrhythmias (EIA), New York Heart Association (NYHA) functional class, heart rate recovery (HRR), Borg CR10 perceived symptoms, and the SF-36 physical and mental health summary scores. A prospective cohort study was conducted with 106 patients undergoing 12 weeks of CPMR who completed two exercise tests pre- and post-CPMR: 1) maximum incremental test (CPX) and 2) submaximal constant load test (SUB). After CPMR, the effects on MIR, EIA, NYHA functional class, and HRR during both tests were analyzed. There was a significant change in NYHA functional classes after CPMR, with 96% of the patients in class I (vs 62% pre-CPMR, P<0.0001), 4% in class II (vs 32%), and none in class III (vs 6%). There was a significant reduction in the frequency of EIA (P<0.05) and MIR (P<0.001) and a significantly improved performance on both CPX and SUB tests (P<0.0001). Lastly, there was significant progress in the recovery metrics like HRR (P<0.0001), the Borg CR10 (P<0.0001), and the SF-36 summary scores (P<0.0001). The CPMR resulted in a significant decrease in EIA, delayed ischemia threshold in CPX and SUB tests, increased functional capacity, and improved quality of life.

Cardiopulmonary exercise testing data processing and storage tools

ABSTRACT Conducting a clinical study is a complex and challenging task, so using technology to facilitate the process is necessary for the medical and scientific community. Data digitization is needed to store and process it. Digitization speeds up data visualization techniques so scientists can analyze it most effectively depending on their goals. In this project, we developed two digital tools related to the cardiopulmonary exercise test (CPET) data, one for digitizing PDF reports and the other for generating databases. The latter was a web-based database visualization dashboard. Users can select parameters of interest and check for differences among subgroups. Basic statistical tests are performed for each variable under analysis, and its results are presented in numerical and graphical formats. The initial statistical tests and the derived recommendation will guide the research team in deeper statistical analysis and robust analysis supporting more decisive conclusions. We ended up with the first version for both tools and validated it using patients' CPET data from the Dante Pazzanese Institute of Cardiology. We conducted a pilot study to verify if the tools served their purpose and observed that both programs worked as planned. The tools can be further tailored to be clinically or research-oriented. On the analysis of CPET's results, the conclusions for our example study were in line with what is presented in the bibliography for cardiorespiratory physiology.

Teste cardiopulmonar de exercício na cardiomiopatia hipertrófica obstrutiva: segurança e valor adicional na estratificação do risco cardiovascular / Cardiopulmonary exercise testing in obstructive hypertrophic cardiomyopathy: safety and additional value in cardiovascular risk stratification

INTRODUÇÃO: A cardiomiopatia hipertrófica (CMHP) é uma doença cardíaca genética comum, com frequência aproximada de 1:500 na população geral e com expressões fenotípicas diversas. A forma obstrutiva caracteriza-se pela presença de gradiente pressórico intraventricular dinâmico, com manifestações mais graves e de difícil controle, sendo a realização de esforço físico contra indicada até recentemente, considerando-se a susceptilidade a arritmias ventriculares graves. Das variáveis do teste ergométrico a pressão arterial sistólica (PAS) é considerada fator determinante para morte súbita. OBJETIVO: avaliar a segurança do TCPE em pacientes com CMPH obstrutiva, bem como avaliar adicionalmente o comportamento de suas variáveis no auxílio à estratificação do risco cardiovascular. MÉTODOS: Foram incluídos pacientes com CMPH obstrutiva que realizaram TCPE entre o ano de 2013 e 2018. RESULTADOS: avaliados 18 pacientes com média de idade de 51 anos (DP 17.1) e 12 (67%) mulheres. Para caracterização anatômica foi empregada a ecodopplercardiografia que evidenciou: gradiente máximo da via de saída do ventrículo esquerdo: de 80 mmHg (DP 32.5); espessura septal (diástole) de 20 mm (DP 6.72); fração de ejeção do ventrículo esquerdo (FEVE) de 69.5 (DP 10.9). Todos em vigência de medicação específica, ressaltando-se os betabloqueadores em 16 pacientes (89%). Das variáveis obtidas durante o esforço, destacam-se as médias de tempo de exercício: 9,1 (DP 2.9) minutos ; frequência cardíaca pico = 111 (DP 19,4) bpm ou 65% do máxima; variação da PAS = 24.5 mmHg (DP 19.4), com curva deprimida em 75% dos pacientes; consumo de oxigênio pico de 18,25 ml.kg-1.min-1(DP 6.4), correspondendo a 62% do valor predito; VE / VCO2 slope = 30,2 (DP 7,60), Razão de trocas respiratórias ou RER = 1,02 (DP 0.13). Não houve arritmias ventriculares sustentadas, parada cardiorrespiratória, ou outra complicação que necessitasse de internação. CONCLUSÃO: Na amostra de pacientes avaliados o TCPE mostrou-se seguro durante sua realização em ambiente hospitalar, com variáveis hemodinâmicas e ventilatórias que podem auxiliar na caracterização prognóstica e no processo de decisão médica. (AU)