A More Selective vs a Standard Risk-Stratified, Heparin-Based, Obstetric Thromboprophylaxis Protocol.

Importance: In 2016, our institution adopted a pregnancy-related venous thromboembolism (VTE) prophylaxis protocol based on American College of Obstetricians and Gynecologists guidelines that recommended postpartum heparin-based chemoprophylaxis (enoxaparin) based on a risk-stratified algorithm. In response to increased wound hematomas without significant reduction in VTE using this protocol, a more selective risk-stratified approach was adopted in 2021. Objective: To evaluate outcomes of the more selective risk-stratified approach to heparin-based obstetric thromboprophylaxis (enoxaparin) protocol. Design, Setting, and Participants: Retrospective observational study of 17 489 patients who delivered at a single tertiary care center in the southeast US between January 1, 2016, and December 31, 2018 (original protocol), and between December 1, 2021, and May 31, 2023 (more selective protocol). Patients receiving outpatient anticoagulation for active VTE or high VTE risk during pregnancy were excluded. Exposure: Standard risk-stratified and more selective postpartum VTE chemoprophylaxis protocols. Main Outcomes and Measures: The primary outcome was clinical diagnosis of wound hematoma up to 6 weeks pos tpartum. The secondary outcome was new diagnosis of VTE up to 6 weeks post partum. We compared baseline characteristics and outcomes between groups and estimated adjusted odds ratios with 95% CIs of primary and secondary outcomes using the original protocol group as reference. Results: Of 17 489 patients included in the analysis, 12 430 (71%) were in the original protocol group and 5029 (29%) were in the more selective group. Rates of chemoprophylaxis decreased from 16% (original protocol) to 8% (more selective protocol). Patients in the more selective group were more likely to be older, be married, and have obesity or other comorbidities (hypertension, diabetes, cardiac disease). Compared with the original protocol, the more selective protocol was associated with a decrease in any wound hematoma (0.7% vs 0.3%; adjusted odds ratio [aOR], 0.38; 95% CI, 0.21-0.67), specifically due to a lower rate of superficial wound hematomas (0.6% vs 0.3%; aOR, 0.43; 95% CI, 0.24-0.75). There was no significant increase in VTE or individual types of VTE (0.1% vs 0.1%; aOR, 0.40; 95% CI, 0.12-1.36). Conclusions and Relevance: A more selective risk-stratified approach to an enoxaparin thromboprophylaxis protocol for VTE was associated with decreased rates of wound hematomas without increased rates of postpartum VTE.

Self-perceived health of older adults in Latin America and the Caribbean: a scoping review.

Objective: To systematically map the existing evidence on self-perceived health among adults aged 60 and older in Latin America and the Caribbean, describe the use of the single-item measure of self-perceived health with this population, and identify gaps in the existing literature. Methods: Following PRISMA Extension for Scoping Reviews guidelines, eight databases were searched for publications that were published between 2009 and 2019 and reported self-perceived health of adults over 60 years old in Latin America and the Caribbean. Data on study characteristics, sample characteristics, and the use and analysis of the self-perceived health measure were charted. Results: The database and secondary searches identified 516 articles. After removing duplicates and assessing titles and abstracts for inclusion, 263 full-text articles were assessed for eligibility using the inclusion criteria and an additional 89 articles were excluded. Ultimately, 174 articles were included in the scoping review. Studies included participants from 17 countries in the region, led in frequency by Brazil with 120 articles. The self-perceived health question most often included a five-category response scale (130), and response options were predominantly divided into two (86) or three (48) categories for analysis. Conclusions: Information on the health and social needs of people aged 60 and older across Latin America and the Caribbean, particularly their perceptions of health, is limited. We highlight the need to expand research throughout the region, include particularly vulnerable populations, utilize data from longitudinal and qualitative studies, and call for transparency in how questions and responses are worded and analyzed. This review serves to inform future studies, programs, and policies directed at this population.

Self-perceived health of older adults in Latin America and the Caribbean: a scoping review / Revisión exploratoria sobre la autopercepción de la salud por las personas mayores en América Latina y el Caribe / Autopercepção de saúde de pessoas idosas na América Latina e no Caribe: revisão de escopo

ABSTRACT Objective. To systematically map the existing evidence on self-perceived health among adults aged 60 and older in Latin America and the Caribbean, describe the use of the single-item measure of self-perceived health with this population, and identify gaps in the existing literature. Methods. Following PRISMA Extension for Scoping Reviews guidelines, eight databases were searched for publications that were published between 2009 and 2019 and reported self-perceived health of adults over 60 years old in Latin America and the Caribbean. Data on study characteristics, sample characteristics, and the use and analysis of the self-perceived health measure were charted. Results. The database and secondary searches identified 516 articles. After removing duplicates and assessing titles and abstracts for inclusion, 263 full-text articles were assessed for eligibility using the inclusion criteria and an additional 89 articles were excluded. Ultimately, 174 articles were included in the scoping review. Studies included participants from 17 countries in the region, led in frequency by Brazil with 120 articles. The self-perceived health question most often included a five-category response scale (130), and response options were predominantly divided into two (86) or three (48) categories for analysis. Conclusions. Information on the health and social needs of people aged 60 and older across Latin America and the Caribbean, particularly their perceptions of health, is limited. We highlight the need to expand research throughout the region, include particularly vulnerable populations, utilize data from longitudinal and qualitative studies, and call for transparency in how questions and responses are worded and analyzed. This review serves to inform future studies, programs, and policies directed at this population.

RESUMEN Objetivo. Realizar una búsqueda sistemática de la evidencia sobre la autopercepción de la salud en las personas mayores de 60 años en América Latina y el Caribe, describir el uso de la medición basada en un solo ítem para dicha autopercepción en este grupo poblacional y detectar posibles lagunas en la bibliografía existente. Métodos. Se realizaron búsquedas en ocho bases de datos de publicaciones aparecidas entre el 2009 y el 2019 sobre la autopercepción de la salud por las personas mayores de 60 años en América Latina y el Caribe. Las búsquedas se realizaron de conformidad con la guía de la extensión PRISMA para revisiones exploratorias. Se graficaron los datos sobre las características del estudio, las características de la muestra y el uso y análisis de la medición de autopercepción de la salud. Resultados. Las búsquedas en las bases de datos y las secundarias permitieron localizar 516 artículos. Tras eliminar los duplicados y examinar los títulos y resúmenes para su inclusión, se utilizaron los criterios de inclusión para evaluar la admisibilidad de 263 artículos completos y se excluyeron otros 89 artículos. A fin de cuentas, quedaron seleccionados 174 artículos para la revisión exploratoria. Los estudios incluían participantes de 17 países de la región, con Brasil como el país con el mayor número (120 artículos). Lo más frecuente fue que la pregunta sobre autopercepción en materia de salud incluyera una escala de respuesta de cinco categorías (130), y las opciones de respuesta se dividían predominantemente en dos (86) o tres (48) categorías para su análisis. Conclusiones. La información sobre las necesidades sociales y de salud de las personas mayores de 60 años en América Latina y el Caribe, en particular sus percepciones sobre la propia salud, es limitada. Los autores destacan la necesidad de ampliar la investigación en toda la región, abarcar a los grupos poblacionales especialmente vulnerables, utilizar datos de estudios longitudinales y cualitativos y exhortar a la transparencia sobre la manera en que se formulan las preguntas y respuestas. Esta revisión sirve como fundamento para futuros estudios, programas y políticas orientados a este grupo poblacional.

RESUMO Objetivo. Mapear de forma sistemática as evidências existentes sobre a autopercepção de saúde em pessoas com 60 anos ou mais na América Latina e no Caribe, descrever o uso de uma medida de item único da autopercepção de saúde nessa população e identificar lacunas na literatura existente. Métodos. Em conformidade com as diretrizes da extensão da ferramenta PRISMA para revisões de escopo, oito bancos de dados foram pesquisados em busca de trabalhos publicados entre 2009 e 2019 que relatassem a autopercepção de saúde de pessoas com mais de 60 anos de idade na América Latina e no Caribe. Foram tabulados dados sobre as características do estudo, as características da amostra e o uso e a análise da medida de autopercepção de saúde. Resultados. As buscas nos bancos de dados e secundárias identificaram 516 artigos. Depois de descartar artigos repetidos e avaliar títulos e resumos para inclusão, 263 artigos completos foram avaliados quanto à elegibilidade usando os critérios de inclusão, o que levou à exclusão de mais 89 artigos. Por fim, 174 artigos foram incluídos na revisão de escopo. Os estudos incluíam participantes de 17 países da região, e o Brasil foi o país com o maior número de publicações: 120 artigos. A pergunta sobre a autopercepção de saúde incluía, na maioria das vezes, uma escala de resposta com cinco categorias (130), e as opções de resposta foram predominantemente divididas em duas (86) ou três (48) categorias para análise. Conclusões. As informações sobre as necessidades sociais e de saúde das pessoas com 60 anos ou mais na América Latina e no Caribe, especialmente suas percepções de saúde, são limitadas. Destacamos a necessidade de expandir a pesquisa em toda a região, incluir populações particularmente vulneráveis, utilizar dados de estudos longitudinais e qualitativos e solicitar transparência na forma como as perguntas e respostas são formuladas e analisadas. Esta análise serve de guia para futuros estudos, programas e políticas voltados para essa população.

Cluster Analysis of Presolar Silicon Carbide Grains: Evaluation of Their Classification and Astrophysical Implications.

Cluster analysis of presolar silicon carbide grains based on literature data for 12C/13C, 14N/15N, δ 30Si/28Si, and δ 29Si/28Si including or not inferred initial 26Al/27Al data, reveals nine clusters agreeing with previously defined grain types but also highlighting new divisions. Mainstream grains reside in three clusters probably representing different parent star metallicities. One of these clusters has a compact core, with a narrow range of composition, pointing to an enhanced production of SiC grains in asymptotic giant branch (AGB) stars with a narrow range of masses and metallicities. The addition of 26Al/27Al data highlights a cluster of mainstream grains, enriched in 15N and 26Al, which cannot be explained by current AGB models. We defined two AB grain clusters, one with 15N and 26Al excesses, and the other with 14N and smaller 26Al excesses, in agreement with recent studies. Their definition does not use the solar N isotopic ratio as a divider, and the contour of the 26Al-rich AB cluster identified in this study is in better agreement with core-collapse supernova models. We also found a cluster with a mixture of putative nova and AB grains, which may have formed in supernova or nova environments. X grains make up two clusters, having either strongly correlated Si isotopic ratios or deviating from the 2/3 slope line in the Si 3-isotope plot. Finally, most Y and Z grains are jointly clustered, suggesting that the previous use of 12C/13C = 100 as a divider for Y grains was arbitrary. Our results show that cluster analysis is a powerful tool to interpret the data in light of stellar evolution and nucleosynthesis modeling and highlight the need of more multi-element isotopic data for better classification.

Brief Report: Assessment Experiences of Children with Neurogenetic Syndromes: Caregivers' Perceptions and Suggestions for Improvement.

It is well-recognized that measurement options for diagnosing and monitoring children with neurogenetic syndromes (NGS) associated with moderate to severe intellectual impairment are limited (Berry-Kravis, Dev Med Child Neurol https://doi.org/10.1111/dmcn.13018, 2016), and caregivers experience significant concerns regarding the assessment process. However to date, these concerns have not been summarized into actionable steps for clinicians and test-makers. As such, we used a mixed methods approach to assess caregiver-derived perceptions and suggestions for improving assessments in NGS. Results indicated many shared challenges and suggestions for improvement, particularly in the domains of testing procedures and examiner communication. Integrating these suggestions into future protocols is an important next step toward improving the quality of assessment procedures for children with NGS and their families across both clinical and research contexts.