In vivo Fate of Targeted Drug Delivery Carriers.

This review aimed to systematically investigate the intracellular and subcellular fate of various types of targeting carriers. Upon entering the body via intravenous injection or other routes, a targeting carrier that can deliver therapeutic agents initiates their journey. If administered intravenously, the carrier initially faces challenges presented by the blood circulation before reaching specific tissues and interacting with cells within the tissue. At the subcellular level, the car2rier undergoes processes, such as drug release, degradation, and metabolism, through specific pathways. While studies on the fate of 13 types of carriers have been relatively conclusive, these studies are incomplete and lack a comprehensive analysis. Furthermore, there are still carriers whose fate remains unclear, underscoring the need for continuous research. This study highlights the importance of comprehending the in vivo and intracellular fate of targeting carriers and provides valuable insights into the operational mechanisms of different carriers within the body. By doing so, researchers can effectively select appropriate carriers and enhance the successful clinical translation of new formulations.

Nowadays, scientists are actively researching nanocarrier drugs. After administration via injection or other methods, these drugs experience in the body and reach the target treatment site to relieve or cure symptoms. As research progresses, scientists are gaining more insights into the behavior of nanocarrier drugs in the body, which is useful in developing safer and more effective drugs. Historically, research has focused primarily on the drug itself. However, it is important to understand that the carrier that delivers and protects the drug (often described as the drug sitting in a "car" or under an "umbrella") plays an essential role in the drug's therapeutic effect. This paper aims to highlight the importance of the carrier's role, which is vital for developing new drugs and advancing basic research.

Magnetic MXene-NH2 decorated with persimmon tannin for highly efficient elimination of U(VI) and Cr(VI) from aquatic environment.

Herein, a magnetic MXenes based composite (Fe3O4@Ti3C2-NH2-PT) was constructed by loading Fe3O4 nano-particles into the interlamellar spacing of persimmon tannin-functionalized Ti3C2-NH2. The structure, morphology and physicochemical properties of the as-prepared adsorbents were probed by advanced spectroscopy techniques, while the impact of various experimental conditions like pH values, amount of adsorbent and contact time on the removal trend were examined by batch experiments. The elimination results revealed that Fe3O4@Ti3C2-NH2-PT could be applied in a wide range of initial concentrations, and exhibited outstanding removal efficiency for U(VI) (104.9 mg/g, pH = 5.0) and Cr(VI) (83.8 mg/g, pH = 2.0). Meanwhile, the adsorption process was described well with the Langmuir isotherm and Pseudo-second-order kinetics models, which indicated that the monolayer chemical adsorption occurred during elimination of the two contaminants. The spectral analysis results manifested that elimination of U(VI) followed an inner-sphere configuration, whereas uptake of Cr(VI) was determined by electrostatic interaction and adsorption-reduction process. This work opened a new opportunity in designing MXenes based adsorbents in the application for environmental remediation.