RESUMO
The aim of this work was to look for a simple method to obtain synchronized ovulation in guinea pigs under farming conditions while respecting animal welfare. The luteolytic activity of three different prostaglandins F2alpha (PGF2α) analogs (D-cloprostenol, D,L-cloprostenol and luprostiol) and a daily treatment with oral progestagen (altrenogest) was tested successively at different stages of the estrous cycle on the same group of females during a period of 8 mo. The estrous cycle length was not modified by the administration of PGF2α analogs, whatever the stage of the estrous cycle when the treatment was initiated. Our results led us to reject the use of PGF2α analog to induce practical synchronization of the estrus in this species. In females (n = 29), given 15 days with altrenogest (0.1 mL po once a day), ovulation occurred 4.43 ± 0.13 days after the end of the treatment. Altrenogest treatment was followed by mating. No negative impacts of the treatment on the pregnancy rates, delivery rates and litter sizes were observed. This standard method of guinea-pig estrus synchronization is less stressful for the animals compared to techniques using progesterone tubing.
Assuntos
Ciclo Estral/fisiologia , Sincronização do Estro/métodos , Cobaias/fisiologia , Animais , Cruzamento/métodos , Cloprostenol/administração & dosagem , Cloprostenol/farmacologia , Cloprostenol/uso terapêutico , Relação Dose-Resposta a Droga , Esquema de Medicação , Ciclo Estral/efeitos dos fármacos , Sincronização do Estro/efeitos dos fármacos , Feminino , Luteolíticos/farmacologia , Luteolíticos/uso terapêutico , Ovulação/efeitos dos fármacos , Ovulação/fisiologia , Gravidez , Prostaglandinas F Sintéticas/administração & dosagem , Prostaglandinas F Sintéticas/farmacologia , Prostaglandinas F Sintéticas/uso terapêutico , Fatores de Tempo , Acetato de Trembolona/administração & dosagem , Acetato de Trembolona/análogos & derivados , Acetato de Trembolona/farmacologia , Acetato de Trembolona/uso terapêuticoRESUMO
A double-blind study was performed on ninety-six parturients of the Lima Maternity Hospital, Peru, with some evidence of foetal distress who were given indistinguishably piracetam or a placebo at random in order to investigate the effects of the drug on the foetus. The conditions of the new-born babies who had received piracetam were superior to those of the babies treated with the placebo, as evaluated with the Apgar at 1, 5 and 10 minutes after birth and on the basis of the neurological and clinical examination as from 24 hours until they were released. In addition, the reduction of the duration of the labour in the patients treated with piracetam as compared with the control group was obvious.
Assuntos
Sofrimento Fetal/tratamento farmacológico , Complicações do Trabalho de Parto/tratamento farmacológico , Piracetam/uso terapêutico , Pirrolidinonas/uso terapêutico , Líquido Amniótico/análise , Índice de Apgar , Peso ao Nascer , Ensaios Clínicos como Assunto , Feminino , Sangue Fetal/análise , Coração Fetal/fisiologia , Frequência Cardíaca , Humanos , Concentração de Íons de Hidrogênio , Recém-Nascido , Piracetam/administração & dosagem , Placenta/anatomia & histologia , Gravidez , Distribuição Aleatória , Fatores de TempoRESUMO
Se hizo un estudio doble ciego en 96 parturientas de Hospital Maternidad de Lima.Peru, con evidencias de sufrimiento fetal, a quienes se les administro indistintamente piracetam o placebo por randomizacion, para estudiar los efectos de la droga sobre el feto. Las condiciones de los recien nacidos que recibieron piracetam fueron superiores a la de aquellos a los que se administro placebo, evaluados por el Apgar a 1,5 y 10 minutos del nascimiento, y por el examen neurologico y clinico, desde las 24 horas hasta que fueron dados de alta.Fue notoria, ademas, la abreviacion de la labor de parto en las pacientes que recibieron piracetam, con relacion al grupo control