Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial.

Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study (ClinicalTrial.gov: NCT03829969), 514 patients with treatment-naïve advanced ESCC were randomized (1:1) to receive toripalimab or placebo in combination with paclitaxel plus cisplatin (TP) every 3 weeks for up to 6 cycles, followed by toripalimab or placebo maintenance. At the prespecified final analysis of progression-free survival (PFS), a significant improvement in PFS is observed for the toripalimab arm over the placebo arm (hazard ratio [HR] = 0.58; 95% CI, 0.46-0.74; p < 0.0001). The prespecified interim analysis of overall survival (OS) also reveals a significant OS improvement for patients treated with toripalimab plus TP over placebo plus TP (HR = 0.58; 95% CI, 0.43-0.78; p = 0.0004). The incidences of grade ≥3 treatment-emergent adverse events are similar between the two arms. Toripalimab plus TP significantly improves PFS and OS in patients with treatment-naïve, advanced ESCC, with a manageable safety profile.

Real-time characterization of FM-AM modulation in a high-power laser facility using an RF-photonics system and a denoising algorithm.

FM-AM modulation of high-power lasers significantly affects laser performance. Therefore, precise measurement of the FM-AM modulation depth is necessary. The subsequent FM-AM modulation generated by group velocity dispersion when the laser pulse propagates through a fiber affects the measurement accuracy. In order to eliminate this effect, a waveform-acquisition module is proposed that converts a broad-spectrum pulse of 1053 nm to a narrow-spectrum pulse of 1550 nm, without affecting the waveform. In addition, a signal-processing algorithm based on the orthogonal matching pursuit method is implemented to remove the sampling noise from the waveform. In this way, the signal-to-noise ratio of the measurement can be readily improved. Both theoretical and experimental results indicate that the proposed FM-AM modulation detection system is effective and economical. It can measure the FM-AM modulation depth precisely, and therefore shows considerable promise for future applications in high-power lasers.

Suppression of FM-to-AM modulation by polarizing fiber front end for high-power lasers.

FM-to-AM modulation is an important effect in the front end of high-power lasers that influences the temporal profile. Various methods have been implemented in standard-fiber and polarization-maintaining (PM)-fiber front ends to suppress the FM-to-AM modulation. To analyze the modulation in the front end, a theoretical model is established and detailed simulations carried out that show that the polarizing (PZ) fiber, whose fast axis has a large loss, can successfully suppress the modulation. Moreover, the stability of the FM-to-AM modulation can be improved, which is important for the front end to obtain a stable output. To verify the model, a PZ fiber front end is constructed experimentally. The FM-to-AM modulation, without any compensation, is less than 4%, whereas that of the PM fiber front end with the same structure is nearly 20%. The stability of the FM-to-AM modulation depth is analyzed experimentally and the peak-to-peak and standard deviation (SD) are 2% and 0.38%, respectively, over 3 h. The experimental results agree with the simulation results and both prove that the PZ fiber front end can successfully suppress the FM-to-AM conversion. The PZ fiber front end is a promising alternative for improving the performance of the front end in high-power laser facilities.