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1.
Mutat Res ; 829: 111878, 2024 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-39151334

RESUMO

RAD51 is critical to the homologous recombination (HR) pathway that repairs DNA double strand breaks (DSBs) and protects replication forks (RFs). Previously, we showed that the S181P (SP) mutation in RAD51 causes defective RF maintenance but is proficient for DSB repair. Here we report that SP/SP female mice exhibit a shortened lifespan compared to +/+ females but not males. Histological analysis found that most mice in this study died from lymphoma, independent of genotype and sex. We propose that a potential cause for shortened lifespan in SP/SP females is due to the RF defect.

2.
Rev. Inst. Med. Trop. Säo Paulo ; 43(5): 271-276, Sept.-Oct. 2001. ilus, tab
Artigo em Inglês | LILACS | ID: lil-308001

RESUMO

Trypanosoma cruzi (Schyzotrypanum, Chagas, 1909), and Chagas disease are endemic in captive-reared baboons at the Southwest Foundation for Biomedical Research, San Antonio, Texas. We obtained PCR amplification products from DNA extracted from sucking lice collected from the hair and skin of T. cruzi-infected baboons, with specific nested sets of primers for the protozoan kinetoplast DNA, and nuclear DNA. These products were hybridized to their complementary internal sequences. Selected sequences were cloned and sequencing established the presence of T. cruzi nuclear DNA, and minicircle kDNA. Competitive PCR with a kDNA set of primers determined the quantity of approximately 23.9 18.2 T. cruzi per louse. This finding suggests that the louse may be a vector incidentally contributing to the dissemination of T. cruzi infection in the baboon colony


Assuntos
Animais , Vetores de Doenças , Infestações por Piolhos , Papio , Ftirápteros , Trypanosoma cruzi , Primers do DNA , DNA de Protozoário , Reação em Cadeia da Polimerase , Trypanosoma cruzi
3.
s.l; s.n; 1991. 4 p. ilus.
Não convencional em Inglês | Sec. Est. Saúde SP, HANSEN, Hanseníase, SESSP-ILSLACERVO, Sec. Est. Saúde SP | ID: biblio-1236410
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