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1.
PLoS One ; 17(7): e0269930, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35853036

RESUMO

New Zealand's Prime Minister, Jacinda Ardern, adopted a "go hard, go early" approach to eliminate COVID-19. Although Ardern and her Labour party are considered left-leaning, the policies implemented during the pandemic (e.g., police roadblocks) have the hallmarks of Right-Wing Authoritarianism (RWA). RWA is characterized by three attitudinal clusters (authoritarian aggression, submission, and conventionalism). The uniqueness of the clusters, and whether they react to environmental change, has been debated. Here, in the context of the pandemic, we investigate the relationship between political orientation and RWA. Specifically, we measured political orientation, support for New Zealand's major political parties, and RWA among 1,430 adult community members. A multivariate Bayesian model demonstrated that, in the middle of a pandemic, both left-leaning and right-leaning individuals endorsed items tapping authoritarian submission. In contrast to authoritarian submission, and demonstrating the multidimensional nature of RWA, we observed the typical relationships between political orientation and authoritarian aggression and conventionalism was observed.


Assuntos
COVID-19 , Política , Adulto , Agressão , Autoritarismo , Teorema de Bayes , COVID-19/epidemiologia , COVID-19/prevenção & controle , Feminino , Humanos
2.
Front Psychol ; 12: 659163, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34093350

RESUMO

Journal editorials, career features, and the popular press commonly talk of a graduate student mental health crisis. To date, studies on graduate student mental health have employed cross-sectional designs, limiting any causal conclusions regarding the relationship between entry into graduate study and mental health. Here, we draw on data from a longitudinal study of undergraduate students in Aotearoa New Zealand, allowing us to compare participants who did, and did not, transition into PhD study following the completion of their undergraduate degree. Using multilevel Bayesian regression, we identified a difference in mental wellbeing between those who entered PhD study and those who did not. This difference, however, was largely due to those not entering PhD study displaying an increase in mental wellbeing. Participants that entered PhD study displayed a small decrease in mental wellbeing, with the posterior distribution of the simple effect heavily overlapping zero. This latter finding was orders of magnitude smaller than one might expect based on previous cross-sectional research and provides an important message; that a marked drop in mental health is not an inevitable consequence of entering graduate study.

4.
Nutrients ; 12(2)2020 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-31978983

RESUMO

There is increasing scientific and public support for the notion that some foods may be addictive, and that poor weight control and obesity may, for some people, stem from having a food addiction. However, it remains unclear how a food addiction model (FAM) explanation for obesity and weight control will affect weight stigma. In two experiments (N = 530 and N = 690), we tested the effect of a food addiction explanation for obesity and weight control on weight stigma. In Experiment 1, participants who received a FAM explanation for weight control and obesity reported lower weight stigma scores (e.g., less dislike of 'fat people', and lower personal willpower blame) than those receiving an explanation emphasizing diet and exercise (F(4,525) = 7.675, p = 0.006; and F(4,525) = 5.393, p = 0.021, respectively). In Experiment 2, there was a significant group difference for the dislike of 'fat people' stigma measure (F(5,684) = 5.157, p = 0.006), but not for personal willpower weight stigma (F(5,684) = 0.217, p = 0.81). Participants receiving the diet and exercise explanation had greater dislike of 'fat people' than those in the FAM explanation and control group (p values < 0.05), with no difference between the FAM and control groups (p >0.05). The FAM explanation for weight control and obesity did not increase weight stigma and resulted in lower stigma than the diet and exercise explanation that attributes obesity to personal control. The results highlight the importance of health messaging about the causes of obesity and the need for communications that do not exacerbate weight stigma.


Assuntos
Dieta/psicologia , Exercício Físico/psicologia , Dependência de Alimentos/psicologia , Obesidade/psicologia , Estigma Social , Adolescente , Adulto , Peso Corporal , Feminino , Humanos , Masculino , Adulto Jovem
5.
Child Dev ; 91(2): e280-e298, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-30698277

RESUMO

Using a between-groups design and random assignment, this study examined 214 Turkish children's (M = 11.66 years) mindreading and general reasoning about in-group members (Turks), similar out-group members (Syrians within Turkey) and dissimilar out-group members (Northern Europeans). Children heard four mindreading and four general reasoning stories with in-group or out-group members as targets. Whereas children's general reasoning about three groups was equivalent, accuracy of mental state inferences differed by target with more accurate mindreading of in-group targets compared to both sets of out-group targets. In this Turkish sample, mindreading of Syrian targets was the least accurate. Prejudice and perceived realistic threat predicted lower mindreading. These findings have important implications for understanding how similarity and intergroup processes play a role in children's mindreading.


Assuntos
Compreensão , Relações Interpessoais , Mentalização , Teoria da Mente , Criança , Feminino , Humanos , Masculino , Preconceito , Turquia
6.
Health Qual Life Outcomes ; 17(1): 123, 2019 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-31311560

RESUMO

BACKGROUND: This exploratory study sought to establish the relationship between endometriosis-related pelvic pain, endometriosis symptom-frequency, and women's subjective wellbeing (SWB). METHODS: A purposive sample (N = 2061) of women with endometriosis aged between 18 and 62 years (M = 30.49 ± 7.45) completed an online questionnaire containing a measure of pelvic pain (Biberoglu & Behrman Scale; B&B), endometriosis symptom frequency, and an established measure of SWB (Personal Wellbeing Index: PWI). RESULTS: Mean SWB total scores (58.35 ± 17.90) were considerably lower than those of women in the general population (western normative range = 70-80; mean = 76). On average, women reported moderate levels of pelvic pain (B&B mean = 5.96 ± 1.84), with a mean of 10.87 (± 4.81) endometriosis-related symptoms across the sample. Significant relationships were found between pelvic pain and SWB dimension and total scores (r's = - 0.20 to - 0.43, all p's < .001), and significant small to medium associations between symptom frequency and all but one of the dimensions of SWB (r's = - 0.12 to - 0.23, all p's < .007). In multivariate regression models accounting for age and delay in diagnosis, higher levels of pelvic pain were significantly associated with lower SWB scores across all eight dimensions of the PWI and total score (all p's < .002). Greater symptom frequency was significantly associated with lower levels of SWB for the dimensions of health, future security, life as a whole, and total scores (all p's < .002). CONCLUSIONS: SWB was lower in women with endometriosis than SWB in women from the general population, and endometriosis related symptoms and pelvic pain explain significant proportions of the unique variance in women's SWB scores. Psychosocial support is needed for women dealing with endometriosis-related symptoms and pain in order to improve their wellbeing and quality of life.


Assuntos
Endometriose/psicologia , Dor Pélvica/psicologia , Qualidade de Vida , Adolescente , Adulto , Endometriose/complicações , Feminino , Humanos , Pessoa de Meia-Idade , Dor Pélvica/etiologia , Índice de Gravidade de Doença , Inquéritos e Questionários , Adulto Jovem
8.
PLoS One ; 14(1): e0210521, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30629716

RESUMO

The Social Identity Approach to Health holds that groups provide us with a sense of meaning and belonging, and that these identity processes have a significant positive impact on our health and wellbeing. Typically, research drawing from the social identity approach with adolescents has focused on the benefits of existing group memberships. Here, using a sail-training intervention, we investigated the impact of providing adolescents with a new group (i.e., a new social identity) on psychological resilience. Across two studies, we demonstrate the benefits of a new social identity, in terms of increases in psychological resilience, flow predominantly to those adolescents who report the lowest levels of resilience at the start of the voyage. We discuss our findings in relation to the social identity approach and adolescent identity development more generally.


Assuntos
Resiliência Psicológica , Identificação Social , Adolescente , Feminino , Humanos , Masculino , Saúde Mental , Militares , Apoio Social
9.
PLoS One ; 13(7): e0200062, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30001332

RESUMO

The current psychology literature defines flourishing as leading an authentic life that directs one towards the highest levels of both feeling good and functioning well. Numerous studies show that flourishing relates to a wide array of advantageous personal outcomes. However, the same literature says very little about the social outcomes of flourishing, even though an individual's pursuit of well-being does not happen in isolation of others. With the present research, we seek to address this void. Specifically, we argue that flourishing, in its psychological conceptualization, does not provide strong moral guidance. As such, flourishing is amoral when it comes to social outcomes such as prosocial behaviors. Drawing on social learning theory, we argue that flourishers' prosociality is at least somewhat contingent on the moral guidance of their society. To assess this, we tested society's corruption level as a moderator in the relation between flourishing and prosocial behavior. To that end, we conducted two studies using data from the European Social Survey (ESS), which were collected in 2006 (N1 = 50,504) from 23 countries and in 2012 (N2 = 56,835) from 29 countries. We generally find that corruption at the national level moderates the relation between flourishing and prosocial behaviors (i.e., helping close/distant others, charitable activities). Overall, our study suggests that moral guidance should factor into discussions about flourishing.


Assuntos
Princípios Morais , Comportamento Social , Inquéritos e Questionários , Europa (Continente) , Humanos
10.
Australas Psychiatry ; 25(2): 154-156, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27679628

RESUMO

OBJECTIVE: Mental health problems are a leading cause of health-related disability during adolescence. The objectives of the current study were to investigate whether participating in an adventure education programme (AEP) increased adolescents' resilience and elucidate how social connectedness contributes to any increase. METHOD: Adolescents who participated in the AEP had their resilience measured on the first (Time 1) and last day (Time 2) of a 10-day voyage. Perceived social support and sense of belonging were also measured at Time 2. A control group of adolescents, who did not take part in the voyage, also had their resilience assessed at two time points, 10 days apart. RESULT: Adolescents who participated in the AEP, but not those in the control group, displayed an increase in resilience from Time 1 to Time 2. Further, the increase in resilience was related to the adolescents' sense of belonging, and this effect held when controlling for perceived social support. CONCLUSION: These findings demonstrate the positive impact AEPs have on adolescents' resilience and a mechanism through which this occurs.


Assuntos
Resiliência Psicológica , Identificação Social , Apoio Social , Adolescente , Educação/métodos , Feminino , Humanos , Masculino , Saúde Mental , Nova Zelândia , Adulto Jovem
11.
Am J Cardiol ; 119(3): 388-396, 2017 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-27956003

RESUMO

To assess the effects of anacetrapib added to statin ± other lipid-modifying therapies in patients with hypercholesterolemia and not at their low-density lipoprotein cholesterol (LDL-C) goal (as per National Cholesterol Education Program Adult Treatment Panel III [NCEP ATP III] guidelines) and in those with low high-density lipoprotein cholesterol (HDL-C). Patients on a stable dose of moderate/high-intensity statin ± other lipid-modifying therapies with LDL-C ≥70, ≥100, ≥130, or ≥160 mg/dl for very high, high, moderate, and low coronary heart disease risk, respectively, or at LDL-C goal with HDL-C ≤40 mg/dl, were randomized 1:1:1, stratified by background therapy use, to anacetrapib 100 mg (n = 153), anacetrapib 25 mg (n = 152), or placebo (n = 154) for 24 weeks, followed by a 12-week off-drug reversal phase. The primary end points were percent change from baseline in LDL-C (beta-quantification method) and HDL-C, as well as the safety profile of anacetrapib. Both doses of anacetrapib reduced LDL-C, non-HDL-C, apolipoprotein (Apo) B, and lipoprotein a and increased HDL-C and Apo AI versus placebo (p <0.001 for all). There were no meaningful differences between the anacetrapib 25 mg, 100 mg, and placebo groups in the proportions of discontinuations due to drug-related adverse events (0.7%, 1.3% vs 1.3%) or in abnormalities in liver enzymes (0%, 0% vs 0.7%), creatine kinase elevations overall (0%, 0.7% vs 0%) or with muscle symptoms (none seen), blood pressure, electrolytes, or adjudicated cardiovascular events (0.7%, 0.7% vs 1.3%). In conclusion, treatment with anacetrapib resulted in substantial reductions in LDL-C and increases in HDL-C and was generally well tolerated.


Assuntos
Anticolesterolemiantes/uso terapêutico , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Hipercolesterolemia/tratamento farmacológico , Oxazolidinonas/uso terapêutico , Idoso , Proteínas de Transferência de Ésteres de Colesterol/antagonistas & inibidores , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Método Duplo-Cego , Quimioterapia Combinada , Dislipidemias/sangue , Dislipidemias/tratamento farmacológico , Ezetimiba/uso terapêutico , Feminino , Ácidos Fíbricos/uso terapêutico , Humanos , Hipercolesterolemia/sangue , Masculino , Pessoa de Meia-Idade , Niacina/uso terapêutico , Resultado do Tratamento
12.
Br J Soc Psychol ; 55(3): 588-99, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27448617

RESUMO

This study sought to examine the role of belonging in the increases in resilience observed following an adventure education programme (AEP). First, we demonstrate that group belonging makes a significant contribution to the improvement in resilience participants' experienced over the course of the AEP. Second, we demonstrate that this increase in resilience is maintained 9 months following the AEP and that group belonging maintained a significant contribution when controlling for participants' initial resilience level and other psychosocial variables (i.e., centrality of identity and social support). Our findings accord well with recent research on the Social Cure or Social Identity Approach to Health and add to a growing body of work identifying the mechanisms underlying this phenomenon.


Assuntos
Processos Grupais , Resiliência Psicológica , Identificação Social , Apoio Social , Adolescente , Feminino , Seguimentos , Humanos , Masculino
13.
Emotion ; 16(2): 226-36, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26461245

RESUMO

This study examined the correlates of right-wing authoritarianism (RWA) in older adults. Participants were given tasks measuring emotion recognition, executive functions and fluid IQ and questionnaires measuring RWA, perceived threat and social dominance orientation. Study 1 established higher age-related RWA across the age span in more than 2,600 New Zealanders. Studies 2 to 4 found that threat, education, social dominance and age all predicted unique variance in older adults' RWA, but the most consistent predictor was emotion recognition, predicting unique variance in older adults' RWA independent of all other variables. We argue that older adults' worse emotion recognition is associated with a more general change in social judgment. Expression of extreme attitudes (right- or left-wing) has the potential to antagonize others, but worse emotion recognition means that subtle signals will not be perceived, making the expression of extreme attitudes more likely. Our findings are consistent with other studies showing that worsening emotion recognition underlies age-related declines in verbosity, understanding of social gaffes, and ability to detect lies. Such results indicate that emotion recognition is a core social insight linked to many aspects of social cognition.


Assuntos
Envelhecimento/psicologia , Autoritarismo , Discriminação Psicológica , Emoções , Predomínio Social , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Atitude , Função Executiva , Feminino , Hostilidade , Humanos , Testes de Inteligência , Masculino , Pessoa de Meia-Idade , Nova Zelândia , Inquéritos e Questionários , Adulto Jovem
14.
J Exp Child Psychol ; 142: 195-202, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26560674

RESUMO

Anti-fat prejudice (weight bias, obesity stigma) is strong, prevalent, and increasing in adults and is associated with negative outcomes for those with obesity. However, it is unknown how early in life this prejudice forms and the reasons for its development. We examined whether infants and toddlers might display an anti-fat bias and, if so, whether it was influenced by maternal anti-fat attitudes through a process of social learning. Mother-child dyads (N=70) split into four age groups participated in a preferential looking paradigm whereby children were presented with 10 pairs of average and obese human figures in random order, and their viewing times (preferential looking) for the figures were measured. Mothers' anti-fat prejudice and education were measured along with mothers' and fathers' body mass index (BMI) and children's television viewing time. We found that older infants (M=11months) had a bias for looking at the obese figures, whereas older toddlers (M=32months) instead preferred looking at the average-sized figures. Furthermore, older toddlers' preferential looking was correlated significantly with maternal anti-fat attitudes. Parental BMI, education, and children's television viewing time were unrelated to preferential looking. Looking times might signal a precursor to explicit fat prejudice socialized via maternal anti-fat attitudes.


Assuntos
Desenvolvimento Infantil , Mães/psicologia , Obesidade/psicologia , Preconceito , Percepção Social , Pré-Escolar , Feminino , Humanos , Lactente , Masculino
15.
PLoS One ; 10(12): e0143970, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26694930

RESUMO

BACKGROUND: Fatigue is a debilitating condition with a significant impact on patients' quality of life. Fatigue is frequently reported by patients suffering from primary Sjögren's Syndrome (pSS), a chronic autoimmune condition characterised by dryness of the eyes and the mouth. However, although fatigue is common in pSS, it does not manifest in all sufferers, providing an excellent model with which to explore the potential underpinning biological mechanisms. METHODS: Whole blood samples from 133 fully-phenotyped pSS patients stratified for the presence of fatigue, collected by the UK primary Sjögren's Syndrome Registry, were used for whole genome microarray. The resulting data were analysed both on a gene by gene basis and using pre-defined groups of genes. Finally, gene set enrichment analysis (GSEA) was used as a feature selection technique for input into a support vector machine (SVM) classifier. Classification was assessed using area under curve (AUC) of receiver operator characteristic and standard error of Wilcoxon statistic, SE(W). RESULTS: Although no genes were individually found to be associated with fatigue, 19 metabolic pathways were enriched in the high fatigue patient group using GSEA. Analysis revealed that these enrichments arose from the presence of a subset of 55 genes. A radial kernel SVM classifier with this subset of genes as input displayed significantly improved performance over classifiers using all pathway genes as input. The classifiers had AUCs of 0.866 (SE(W) 0.002) and 0.525 (SE(W) 0.006), respectively. CONCLUSIONS: Systematic analysis of gene expression data from pSS patients discordant for fatigue identified 55 genes which are predictive of fatigue level using SVM classification. This list represents the first step in understanding the underlying pathophysiological mechanisms of fatigue in patients with pSS.


Assuntos
Fadiga/genética , Análise de Sequência com Séries de Oligonucleotídeos/métodos , Síndrome de Sjogren/complicações , Transcriptoma , Adulto , Idoso , Área Sob a Curva , Fadiga/sangue , Fadiga/etiologia , Feminino , Predisposição Genética para Doença , Humanos , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Síndrome de Sjogren/sangue
16.
Drug Alcohol Rev ; 29(6): 676-83, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-20973854

RESUMO

INTRODUCTION AND AIMS: High-profile sportspeople are posited as role models for others. We examine whether university sportspeople and non-sportspeople's perceptions of high-profile sportspeople's (sports stars) and friends perceived drinking behaviours are related to their own drinking behaviours. Further, we examine the importance of drinking with competitors after sports events. DESIGN AND METHODS: A convenience sample of 1028 participants (58% females, n=652 sportspeople) from two Australian universities were approached at sporting and university venues. Participants completed a survey booklet containing demographic questions, the Alcohol Use Disorders Identification Test (AUDIT, alcohol measure), perceived drinking of high-profile sportspeople and friends (social norms), and for sportspeople only, items assessing the importance of drinking with competitors. Bivariate and multivariate analyses were used to assess relationships. RESULTS: Both sporting and non-sporting participants perceived high-profile sportspeople to drink less than themselves and their friends. Small significant bivariate relationships were found between high-profile sportspeople's perceived drinking and self-reported drinking for sportspeople (r=0.20, P <0.0005). However, in multivariate regression models the perceived drinking behaviours of high-profile sportspeople were not significant predictors of sportspeople's drinking, and were negatively related to non-sportspeople's drinking. The practice of drinking with competitors after sports and games accounted for an additional 6.1% of the unique variance in AUDIT-scores (P<0.0005). DISCUSSION AND CONCLUSIONS: Sports stars are touted as negative role models when it comes to drinking. Contrary to expectations high-profile sportspeople were not perceived to be heavy drinkers and their perceived drinking was not predictive of others drinking. Friends' and normative drinking practices were predictors of drinking.[O'Brien KS, Kolt GS, Webber A, Hunter JA. Alcohol consumption in sport: The influence of sporting idols, friends and normative drinking practices.


Assuntos
Consumo de Bebidas Alcoólicas/psicologia , Esportes , Adulto , Etanol , Feminino , Amigos , Humanos , Masculino , Fatores Sexuais , Meio Social , Valores Sociais , Estudantes , Inquéritos e Questionários , Universidades , Adulto Jovem
17.
Obesity (Silver Spring) ; 18(11): 2138-44, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-20395952

RESUMO

Anti-fat sentiment is increasing, is prevalent in health professionals, and has health and social consequences. There is no evidence for effective obesity prejudice reduction techniques in health professionals. The present experiment sought to reduce implicit and explicit anti-fat prejudice in preservice health students. Health promotion/public health bachelor degree program students (n = 159) were randomized to one of three tutorial conditions. One condition presented an obesity curriculum on the controllable reasons for obesity (i.e., diet/exercise). A prejudice reduction condition presented evidence on the uncontrollable reasons for obesity (i.e., genes/environment); whereas a neutral (control) curriculum focused on alcohol use in young people. Measures of implicit and explicit anti-fat prejudice, beliefs about obese people, and dieting, were taken at baseline and postintervention. Repeated measures analyses showed decreases in two forms of implicit anti-fat prejudice (decreases of 27 and 12%) in the genes/environment condition relative to other conditions. The diet/exercise condition showed a 27% increase in one measure of implicit anti-fat prejudice. Reductions in explicit anti-fat prejudice were also seen in the genes/environment condition (P = 0.006). No significant changes in beliefs about obese people or dieting control beliefs were found across conditions. The present results show that anti-fat prejudice can be reduced or exacerbated depending on the causal information provided about obesity. The present results have implications for the training of health professionals, especially given their widespread negativity toward overweight and obesity.


Assuntos
Atitude do Pessoal de Saúde , Cultura , Obesidade/psicologia , Preconceito , Saúde Pública/educação , Adolescente , Adulto , Currículo , Dieta Redutora/psicologia , Meio Ambiente , Feminino , Predisposição Genética para Doença , Promoção da Saúde , Humanos , Masculino , Fatores de Risco , Estudantes/psicologia , Inquéritos e Questionários , Adulto Jovem
19.
Obesity (Silver Spring) ; 16 Suppl 2: S87-92, 2008 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18978769

RESUMO

OBJECTIVE: The aim of this study was to investigate discrimination against obese job candidates, and to examine whether widely used measures of implicit and explicit antifat attitudes are related to or predict antifat discrimination. METHODS AND PROCEDURES: One hundred university students made job candidate suitability ratings of resumes submitted for a bogus managerial position. Photos attached to each resume portrayed the job candidate as either obese or normal weight, by using pre- and postprocedure photos of individuals who had undergone bariatric surgery. To assess discrimination, job candidates' ratings were compared between obese and normal-weight targets. Implicit and explicit antifat attitudes were also assessed. RESULTS: Participants rated obese job candidates as having less leadership potential, as less likely to succeed, and as less likely to be employed than normal-weight candidates. Obese candidates were also given a lower starting salary and ranked as less qualified overall than candidates portrayed as normal weight. Neither implicit nor explicit antifat attitude measures were significantly related to antifat discrimination. DISCUSSION: This study found strong evidence of employment-related discrimination against obese individuals. Commonly used measures of antifat attitudes do not appear to be adequate predictors of antifat discrimination. Improved questionnaire measures may be needed to better predict actual prejudiced behavior.


Assuntos
Peso Corporal , Conhecimentos, Atitudes e Prática em Saúde , Candidatura a Emprego , Obesidade/psicologia , Seleção de Pessoal , Preconceito , Estereotipagem , Adolescente , Adulto , Feminino , Humanos , Liderança , Masculino , Obesidade/fisiopatologia , Fotografação , Competência Profissional , Salários e Benefícios , Inquéritos e Questionários , Local de Trabalho/psicologia , Adulto Jovem
20.
Photodermatol Photoimmunol Photomed ; 24(5): 268-9, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-18811869

RESUMO

The mechanisms whereby narrowband ultraviolet B (UVB) (311-313 nm, TL01) phototherapy are effective in psoriasis may differ from those occurring in broadband UVB phototherapy. In the present study, changes in epidermal cells as a result of TL01 therapy were assessed in the skin of patients with psoriasis. The non-lesional skin of five subjects with plaque psoriasis was biopsied before and after a series of 12 whole-body TL01 treatments. Following appropriate staining of skin sections, the numbers of p53-positive keratinocytes, sunburn cells and Langerhans cells in the epidermis were counted. TL01 therapy induced a threefold increase in the number of p53-positive epidermal cells, a 12-fold increase in sunburn cells and a twofold decrease in Langerhans cells. The increase in epidermal p53 expression and apoptosis of keratinocytes together with the depletion of Langerhans cells in the non-lesional skin of psoriasis patients are likely to contribute to the effectiveness of TL01 phototherapy.


Assuntos
Apoptose/efeitos da radiação , Queratinócitos/metabolismo , Psoríase/metabolismo , Psoríase/terapia , Pele/metabolismo , Terapia Ultravioleta , Adulto , Idoso , Contagem de Células , Feminino , Humanos , Queratinócitos/patologia , Células de Langerhans/metabolismo , Células de Langerhans/patologia , Masculino , Pessoa de Meia-Idade , Psoríase/patologia , Pele/patologia , Proteína Supressora de Tumor p53/metabolismo , Terapia Ultravioleta/métodos
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