[The diagnostic importance of chronocardiometry in patients with chronic inflammatory lung diseases]. / Diagnosticheskoe znachenie khronokardiometrii u bol'nykh khronicheskimi vospalitel'nymi zabolevaniiami legkikh.

Based on an examination of 14 patients with chronic inflammatory pulmonary diseases the authors compared results of a study of the phase structure of the cardiac ventricular systole with data of two-dimensional echocardiography. Data of phasic analysis of the ventricular systole indicate the presence of several phasic syndromes. Hyperdynamia and hypodynamia of the myocardium were most frequent syndromes. Results of correlation analysis of the dependence of ejection fractions and indices of the ventricular systole structures were not significantly interdependent. Thus, results do not confirm diagnostic value of ventricular systole phase structure in assessment of the contractile function of the myocardium in patients with chronic inflammatory pulmonary diseases.

[Value of different indirect methods of diagnosis of pulmonary hypertension]. / Lechenie nekotorykh kosvennykh metodov diagnostiki legochnoi gipertenzii.

Dependence of the duration of right-ventricular isometric relaxation phase (IRP) on right ventricular systolic pressure (SP) and heart rate was studied. IRP was measured using echography of the tricuspid valve and SP value was determined according to the data of heart venous catheterization. Examination included 30 patients with chronic inflammatory pulmonary diseases. A low dependence was found between IRP, SP and HR, which is of little use for the indirect establishment of the pressure value in pulmonary circulation. Errors during right-ventricular SP measurement using methods based on the IRP analysis show their unreliability. A method for measuring pressure value in pulmonary circulation has been suggested which is based on the data of echography. Despite the high correlative coefficient of the estimated and actual values, the method makes it possible to obtain only the approximate data.

[Pulmonary ventilation and central hemodynamics in pulmonary tuberculosis patients]. / Sostoianie legochnoi ventiliatsii i tsentral'noi gemodinamiki u bol'nykh tuberkulezom legkikh.

Computerized devices were used for evaluation of the state of pulmonary ventilation and central hemodynamics in 32 patients with pulmonary tuberculosis depending on the spread of the specific process. Patients with limited changes in the lungs, showed disorders of bronchial patency and compensatory increase of organic ejection of the right ventricle. In the presence of spread changes in the lungs the above mentioned changes were supplemented by restrictive ventilation disorders with a reduction of the contractile myocardial capacity. These functional changes should be considered in the treatment of patients with pulmonary tuberculosis.

[Use of beta 1-adrenostimulants in circulatory failure in patients with chronic inflammatory lung diseases]. / Primenenie beta 1-adrenostimuliatorov pri nedostatochnosti krovoobrashcheniia u bol'nykh s khronicheskimi vospalitel'nymi zabolevaniiami legkikh.

In 34 patients with chronic cor pulmonale, the drugs from a group of beta-adrenostimulants, nonachlazinum and oxyphedrinum, were tested for effects on their hemodynamics, pulmonary ventilation function, blood gas composition and acid-base balance. In patients with circulatory failure due to lung diseases, nonachlazinum and oxyphedrinum were found to exert a pronounced positive intropic action, to contribute to an increase in cardiac output. The agents may be included into the multimodality therapy of patients with decompensated chronic cor pulmonale.

[Vasoconstrictor action of ibuprofen in treating patients with pulmonary hypertension]. / O vazokonstriktornom deistvii ibuprofena pri lechenii bol'nykh s legochnoi gipertenziei.

A study of patients with pulmonary hypertension caused by chronic inflammatory pulmonary diseases revealed that ibuprofen may induce an elevation of the pressure in the lesser circulation that is most probably connected with inhibition of synthesis of prostacyclin and prostaglandins of type E.

[The effect of ibuprofen on the hemodynamics of the lesser circulation in patients with pulmonary hypertension]. / Vliianie ibuprofena na sostoianie gemodinamiki malogo kruga u bol'nykh s legochnoi gipertenziei.

The effect of ibuprofen on pulmonary circulation hemodynamics, pulmonary ventilation and blood gaseous metabolism was studied under conditions of cardiac venous catheterization in 8 patients with pulmonary hypertension caused by chronic inflammatory diseases of the lungs. After oral use of ibuprofen in a dose of 0.4 g, there was (in 7 out of the 8 patients) an increase in the right ventricle systolic pressure at an average by 5.9 +/- 2.39 mm Hg (p less than 0.05). The time course of the echocardiographic indices in the majority of the patients was evident of an increase in the right ventricle postload. No definite tendencies in changing of pulmonary ventilation and blood gaseous metabolism were observed. Inhibition of synthesis of prostacyclin and type E prostaglandin having a vasodilating action is the most likely mechanism of the ibuprofen vasoconstrictive effect.

[The importance of ultrasonic study of the right heart ventricle and pulmonary artery in the diagnosis of hypertension of the lesser circulation]. / Znachenie ul'trazvukovogo issledovaniia pravogo zheludochka serdtsa i legochnoi arterii v diagnostike gipertenzii malogo kruga krovoobrashcheniia.

The data obtained during ultrasonic examination of the right heart ventricle and pulmonary artery are compared to the data of venous catheterization of the heart in 30 patients with chronic pulmonary diseases. Significant direct relationship was established between the correlations of the right and left ventricle volumes, the end diastolic and systolic volumes of the right ventricle, the cross section area of the right main pulmonary artery as was an inverse relationship between the ejection fraction and systolic effective pressure in the right ventricle. In bronchopulmonary diseases, two-dimensional echocardiography is an informative enough method not only in the assessment of hypertrophy, dilatation and failure of the right heart ventricle but also in indirect diagnosis of pulmonary circulation hypertension.

[Correction of hemodynamics in patients with acute pneumonia]. / Korrektsiia gemodinamiki u bol'nykh ostroi pnevmoniei.

Patients with acute pneumonia demonstrate disturbance of myocardial contractility manifesting itself in an increase of end diastolic and systolic volumes, a decrease in the ejection fraction and circular myocardial contractility rate. In a raised level of mean arterial pressure i.v. administration of strophanthin in acute pneumonia can produce a negative effect in the form of a decrease in the stroke volume and cardiac output. Myofedrin promotes an increase in cardiac ejection and can be used for therapy of patients with acute pneumonia to correct hemodynamics.