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1.
J Oral Rehabil ; 45(8): 598-604, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29761827

RESUMO

Clinicians' evaluations of older adults sometimes reveal inconsistencies between objective and subjective dental status. This study investigated which factors contribute both to good objective masticatory function (OMF) and the poor subjective masticatory function (SMF) that often becomes a clinical issue. Study participants included 635 elderly community-dwelling Japanese adults who underwent a comprehensive geriatric health examination in 2012. SMF was assessed with a question from the Kihon Checklist on eating difficulties (poor or good). OMF was assessed by a colour-changing gum (poor or good). Also investigated were age, sex, depressive symptoms, instrumental activities of daily living (I-ADLs), number of people who joined the participant at dinner, grip strength, usual walking speed, number of remaining teeth, number of functional teeth and their occlusal force. The group with good OMF and good SMF, defined as group 1, and the group with good OMF but poor SMF, group 2, were compared. Logistic regression analyses confirmed that the number of remaining and functional teeth participants had was statistically unrelated to differences between OMF and SMF. Instead, differences were related to stronger depressive symptoms (OR = 1.67, CI = 1.14-2.44), less ability to conduct I-ADL activities (OR = 0.73, CI = 0.59-0.91), slower usual walking speeds (OR = 0.18, CI = 0.06-0.58) and less occlusal force (OR = 0.99, CI = 0.99-1.00). Depressive symptoms, I-ADLs, and physical function are shown to be significantly related to divergence between objective and subjective masticatory function in elderly Japanese. This suggests that dissociations between objective and subjective dental evaluations of elderly adults indicate need for assessment of their mental and physical function.


Assuntos
Depressão/epidemiologia , Ingestão de Alimentos/fisiologia , Avaliação Geriátrica , Mastigação/fisiologia , Saúde Bucal/estatística & dados numéricos , Atividades Cotidianas , Idoso , Força de Mordida , Estudos Transversais , Feminino , Força da Mão/fisiologia , Humanos , Vida Independente , Japão , Masculino
2.
J Nutr Health Aging ; 22(3): 451-456, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29484361

RESUMO

Providing older person individuals with an appropriate intervention at the time of frailty onset is important to prevent the progression of the condition and the need for long-term care. However, the proper timing of starting nutritional and dietary interventions for frail older person subjects has not been fully elucidated. Therefore, in this cross-sectional study, we aimed to clarify the association between frailty and dietary variety among older persons in Japan. We surveyed sex, age, body height, body weight, body mass index, serum albumin level, dietary variety, and nutritional intake indexes in 747 community-dwelling older person individuals who underwent a comprehensive health examination in October 2014. Frailty was determined using the Kihon Checklist (25 questions). Kihon Checklist is widely used to assess frailty in Japan, and their physical, cognitive and social function was evaluated. After excluding those who did not complete the Kihon Checklist and those who required long-term care, frailty status was analyzed in 665 older person individuals. The numbers and percentages of frail, pre-frail and robust older persons were found to be 77 (11.6%), 182 (27.4%) and 406 (61.0%) respectively. Significant differences among robust, pre-frail, and frail subjects were observed in terms of age, serum albumin level, alcohol consumption, smoking, and history of diabetes. Among the nutrition-related indexes, only the dietary variety showed a significant difference. The results of ordinal logistic regression analysis showed a significant association between frailty and sex, age, smoking status, diabetes, and dietary variety score. Dietary variety was significantly associated with the progression of frailty among older persons in the community.


Assuntos
Dieta/métodos , Comportamento Alimentar , Fragilidade/dietoterapia , Avaliação Geriátrica/métodos , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Idoso Fragilizado , Nível de Saúde , Humanos , Vida Independente , Japão , Masculino , Inquéritos e Questionários
3.
J Nutr Health Aging ; 21(6): 710-714, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28537337

RESUMO

BACKGROUND: Aging anorexia, defined as loss of appetite and/or reduced food intake, has been postulated as a risk factor for frailty. Impairments of taste and smell perception in elderly people can lead to reduced enjoyment of food and contribute to the anorexia of aging. OBJECTIVE: To evaluate the relationship between frailty and taste and smell perception in elderly people living in urban areas. DESIGN: Data from the baseline evaluation of 768 residents aged ≥ 65 years who enrolled in a comprehensive geriatric health examination survey was analyzed. Fourteen out of 29-items of Appetite, Hunger, Sensory Perception questionnaire (AHSP), frailty, age, sex, BMI, chronic conditions and IADL were evaluated. AHSP was analyzed as the total score of 8 taste items (T) and 6 smell items (S). Frailty was diagnosed using a modified Fried's frailty criteria. RESULTS: The area under the receiver operator curves for detection of frailty demonstrated that T (0.715) had moderate accuracy, but S (0.657) had low accuracy. The cutoffs, sensitivity, specificity and Youden Index (YI) values for each perception were T: Cutoff 26.5 (YI: 0.350, sensitivity: 0.639, specificity: 0.711) and S: Cutoff 18.5 (YI: 0.246, sensitivity: 0.690, specificity: 0.556). Results from multiple logistic regression models, after adjusting for age, sex, IADL and chronic conditions showed that participants under the T cutoff were associated with exhaustion and those below the S cutoff were associated with slow walking speed. The adjusted logistic models for age, sex, IADL and chronic conditions showed significant association between T and frailty (OR 2.81, 95% CI 1.29-6.12), but not between S and frailty (OR 1.73, 95% CI 0.83-3.63). CONCLUSIONS: Taste and smell perception, particularly taste perception, were associated with a greater risk of frailty in community-dwelling elderly people. These results suggest that lower taste and smell perception may be an indicator of frailty in old age.


Assuntos
Envelhecimento/fisiologia , Apetite/fisiologia , Idoso Fragilizado/estatística & dados numéricos , Avaliação Geriátrica/métodos , Fome/fisiologia , Sensação/fisiologia , Olfato/fisiologia , Paladar/fisiologia , Idoso , Idoso de 80 Anos ou mais , Anorexia , Fadiga , Feminino , Humanos , Masculino , Percepção/fisiologia , Fatores de Risco , Inquéritos e Questionários
4.
Diabet Med ; 34(4): 586-589, 2017 04.
Artigo em Inglês | MEDLINE | ID: mdl-27859559

RESUMO

AIM: To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children. METHODS: We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined. RESULTS: The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20-2.35); corrected P value = 0.0075]. CONCLUSIONS: The FUT2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children.


Assuntos
Diabetes Mellitus Tipo 1/genética , Fucosiltransferases/genética , Sistema ABO de Grupos Sanguíneos/genética , Povo Asiático/genética , Estudos de Casos e Controles , Predisposição Genética para Doença , Humanos , Japão , Galactosídeo 2-alfa-L-Fucosiltransferase
5.
Diabet Med ; 33(12): 1717-1722, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27352912

RESUMO

AIMS: The aim of this study was to clarify the significance of previously reported susceptibility variants in the development of autoimmune Type 1 diabetes in non-white children. Tested variants included rs2290400, which has been linked to Type 1 diabetes only in one study on white people. Haplotypes at 17q12-q21 encompassing rs2290400 are known to determine the susceptibility of early-onset asthma by affecting the expression of flanking genes. METHODS: We genotyped 63 variants in 428 Japanese people with childhood-onset autoimmune Type 1 diabetes and 457 individuals without diabetes. Possible association between variants and age at diabetes onset was examined using age-specific quantitative trait locus analysis and ordered-subset regression analysis. RESULTS: Ten variants, including rs2290400 in GSDMB, were more frequent among the people with Type 1 diabetes than those without diabetes. Of these, rs689 in INS and rs231775 in CTLA4 yielded particularly high odds ratios of 5.58 (corrected P value 0.001; 95% CI 2.15-14.47) and 1.64 (corrected P value 5.3 × 10-5 ; 95% CI 1.34-2.01), respectively. Age-specific effects on diabetes susceptibility were suggested for rs2290400; heterozygosity of the risk alleles was associated with relatively early onset of diabetes, and the allele was linked to the phenotype exclusively in the subgroup of age at onset ≤ 5.0 years. CONCLUSIONS: The results indicate that rs2290400 in GSDMB and polymorphisms in INS and CTLA4 are associated with the risk of Type 1 diabetes in Japanese children. Importantly, cis-regulatory haplotypes at 17q12-q21 encompassing rs2290400 probably determine the risk of autoimmune Type 1 diabetes predominantly in early childhood.


Assuntos
Cromossomos Humanos Par 17/genética , Diabetes Mellitus Tipo 1/genética , Haplótipos/genética , Polimorfismo de Nucleotídeo Único/genética , Adolescente , Adulto , Idade de Início , Idoso , Alelos , Criança , Pré-Escolar , Feminino , Frequência do Gene/genética , Predisposição Genética para Doença/genética , Humanos , Lactente , Japão/etnologia , Masculino , Pessoa de Meia-Idade , Adulto Jovem
6.
Transl Psychiatry ; 6: e782, 2016 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-27070410

RESUMO

Serum levels of brain-derived neurotrophic factor (BDNF) are low in major depressive disorder (MDD), and were recently shown to decrease in chronic depression, but whether this is a trait or state marker of MDD remains unclear. We investigated whether serum BDNF levels decrease before or after the developments of MDD and other mood disorders through a case-control study nested in a cohort of 1276 women aged 75-84 years in 2008. Psychiatrists using the Structured Clinical Interview for DSM-IV identified incident cases of mood disorders at follow-up surveys in 2010 and 2012: 28 of MDDs, 39 of minor depressive disorders (minDDs) and 8 of minor depressive episodes with a history of major depressive episodes (minDEs with MDE history). A total of 106 representative non-depressed controls were also identified in the 2012 follow-up. We assayed BDNF levels in preserved sera of cases and controls at baseline and at follow-up. Serum BDNF levels at baseline in cases of MDD, minDD or minDE with MDE history were no lower than those in controls. The decrease in the serum BDNF level from baseline to follow-up was greater in cases of MDD or minDE with MDE history than in controls or cases of minDD. These results show that serum BDNF levels are not a trait marker of MDD in old women but appeared to be a state marker. The different changes in BDNF levels among diagnostic groups suggest that MDD has a pathophysiologic relation to minDE with MDE history, rather than to minDD.


Assuntos
Fator Neurotrófico Derivado do Encéfalo/sangue , Transtornos do Humor/sangue , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/sangue , Estudos de Casos e Controles , Estudos de Coortes , Feminino , Humanos , Tempo , Tóquio
7.
Genes Brain Behav ; 15(4): 429-40, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26463820

RESUMO

K(+) /Cl(-) cotransporters (KCCs) are known to be crucial in the control of neuronal electrochemical Cl(-) gradient. However, the role of these proteins in glial cells remains largely unexplored despite a number of studies showing expression of KCC proteins in glial cells of many species. Here, we show that the Caenorhabditis elegans K(+) /Cl(-) cotransporter KCC-3 is expressed in glial-like cells and regulates the thermosensory behavior through modifying temperature-evoked activity of a thermosensory neuron. Mutations in the kcc-3 gene were isolated from a genetic screen for mutants defective in thermotaxis. KCC-3 is expressed and functions in the amphid sheath glia that ensheathes the AFD neuron, a major thermosensory neuron known to be required for thermotaxis. A genetic analysis indicated that the regulation of the thermosensory behavior by KCC-3 is mediated through AFD, and we further show that KCC-3 in the amphid sheath glia regulates the dynamics of the AFD activity. Our results show a novel mechanism by which the glial KCC-3 protein non-cell autonomously modifies the stimulus-evoked activity of a sensory neuron and highlights the functional importance of glial KCC proteins in modulating the dynamics of a neural circuitry to control an animal behavior.


Assuntos
Proteínas de Caenorhabditis elegans/genética , Neuroglia/fisiologia , Simportadores/genética , Animais , Animais Geneticamente Modificados , Comportamento Animal , Caenorhabditis elegans , Proteínas de Caenorhabditis elegans/metabolismo , Células Receptoras Sensoriais/metabolismo , Simportadores/metabolismo , Temperatura , Cotransportadores de K e Cl-
8.
Phys Rev Lett ; 114(24): 247209, 2015 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-26197009

RESUMO

In 5d Ir oxides with an interplay of spin-orbit coupling and electron correlations, we have tailored a spin-orbital magnetic insulator out of a semimetal SrIrO(3) by tuning the structure through superlattices [(SrIrO(3))(m), SrTiO(3)] (m=1,2,3,4, and ∞). We observed the systematic decrease of the magnetic ordering temperature and the resistivity as a function of m. The transition from the semimetal to the insulator is found to be closely linked to the appearance of magnetism at m≃3. Long range magnetic ordering was realized even in the m=1 single layer superlattice, implying that the design and realization of novel electronic phases is feasible at the level of a single atomic layer in complex Ir oxides.

9.
J Dairy Sci ; 98(5): 2875-83, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25704969

RESUMO

The emulsifying components in cream are very important in controlling the physical characteristics of whipped cream. The effects of those components on the stability of fat globules and the physical characteristics of whipped cream were investigated. A low-molecular-weight emulsifier, and protein ingredients such as sodium caseinate and a casein partial hydrolysate (casein peptides), were used as emulsifying components in this investigation. The viscosity of deaerated whipped cream (called the serum viscosity) was measured to evaluate the degree of fat-globule aggregation. Furthermore, the shape-retention ability, which is the degree of reduction in the firmness of whipped cream between immediately after whipping and after 1d of refrigeration, was explored. The addition of the low-molecular-weight emulsifier in the continuous phase of dairy cream, which does not contain added low-molecular-weight emulsifiers, increased the stability of the fat globules and reduced the shape-retention ability of the whipped cream. The addition of protein ingredients (sodium caseinate and casein peptides) to the continuous phase of dairy cream had little effect. However, the addition of casein peptide in the continuous phase of dairy cream together with the low-molecular-weight emulsifier reduced the effect of the low-molecular-weight emulsifier on the stabilization of fat globules and the shape-retention ability of the whipped cream. The addition of casein peptide did not recover the serum viscosity; thus, other mechanisms might underlie this phenomenon.


Assuntos
Caseínas/química , Laticínios/análise , Emulsificantes/química , Glicolipídeos/química , Glicoproteínas/química , Animais , Emulsões/química , Gotículas Lipídicas
10.
Eur J Clin Microbiol Infect Dis ; 32(10): 1353-7, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23681154

RESUMO

Children with severe motor intellectual disabilities (SMID) are at high risk of death from acute viral lower respiratory tract infections (LRTI). Although respiratory syncytial virus (RSV) is the most common cause of viral LRTI in children, there have been a few reports on the relationship between SMID and the severity of RSV-LRTI. The aim of the present study is to assess the influence of RSV-LRTI in children with SMID. A case-control study composed of children with SMID (n = 18) and previously healthy children (n = 43) less than 16 years old hospitalized for RSV-LRTI was performed during five consecutive RSV seasons. The clinical presentation and the laboratory data in the SMID group were compared with those in the non-SMID group. In the bivariate analysis, the median age of the SMID group was higher than that of the non-SMID group (p = 0.002). Children with SMID had an increased risk for ventilation support (p = 0.057). The count of neutrophils in the SMID group was significantly increased (p = 0.012), whereas the proportion of bacterial co-infection was lower than that in the non-SMID group (p = 0.005). Multivariate logistic analysis showed that SMID was associated with longer oxygen usage [>7 days: odds ratio (OR) 5.309, p = 0.033]. The present study revealed that children with SMID were prone to developing hypoxia by RSV-LRTI. The strategies for the treatment and prevention of RSV infection need to be improved in SMID children.


Assuntos
Pessoas com Deficiência , Deficiência Intelectual/complicações , Paraplegia/complicações , Infecções por Vírus Respiratório Sincicial/epidemiologia , Vírus Sincicial Respiratório Humano/isolamento & purificação , Estudos de Casos e Controles , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Infecções por Vírus Respiratório Sincicial/patologia , Estudos Retrospectivos , Fatores de Risco
12.
Int J Immunogenet ; 39(2): 119-25, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22117627

RESUMO

Abnormal immunological responses to certain microbial agents may play a crucial role in the pathogenesis of Kawasaki disease (KD). The association studies between histo-blood group genes (Lewis and ABO blood types) and various types of infectious diseases or vasculopathy have been carried out based on the fact that glycosylated antigens could directly mediate microbial infections. We attempted to clarify the role of blood type antigens in the development of KD and coronary artery lesions in KD patients. The subjects included 164 KD patients enrolled from 1998 to 2003 (1st group), 232 patients from 2004 to 2009 (2nd group), and 223 healthy children and 118 patients with growth hormone deficiency as controls. The genotyping of the FUT2 and FUT3 genes, and ABO genotypes, was determined with the TaqMan SNP assay and allele-specific polymerase chain reaction. No significant differences were observed in the genotypes and allele frequencies of the FUT2 and FUT3 genes between the groups. The frequency of the BB blood genotype was significantly higher in KD patients with coronary artery lesions in the 1st and 2nd groups than in the controls (17% and 14% vs. 5%, P = 0.0020). This is the first report to investigate the roles of ABO and Lewis blood types in the development of KD, and in the formation of coronary artery lesions in KD patients. These data suggest that the ABO blood type may play a role in the development of coronary artery lesions in KD patients.


Assuntos
Sistema ABO de Grupos Sanguíneos/genética , Doença da Artéria Coronariana/genética , Vasos Coronários/patologia , Predisposição Genética para Doença , Síndrome de Linfonodos Mucocutâneos/sangue , Polimorfismo Genético , Alelos , Estudos de Casos e Controles , Pré-Escolar , Doença da Artéria Coronariana/sangue , Doença da Artéria Coronariana/patologia , Feminino , Fucosiltransferases/genética , Frequência do Gene , Técnicas de Genotipagem , Humanos , Lactente , Antígenos do Grupo Sanguíneo de Lewis/genética , Masculino , Síndrome de Linfonodos Mucocutâneos/genética , Síndrome de Linfonodos Mucocutâneos/patologia , Estações do Ano , Galactosídeo 2-alfa-L-Fucosiltransferase
13.
Acta Neurochir (Wien) ; 154(1): 173-8; discussion 178, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22072218

RESUMO

BACKGROUND: Schwannoma is the most common tumor of the peripheral nerves, with surgical enucleation being the established treatment modality. However, some schwannomas cannot be easily enucleated and this sometimes results in iatrogenic nerve injury even with atraumatic procedures. Here we present a retrospective review of the management of schwannoma in the extremities and compare clinical outcomes from the two techniques of extra-capsular and intra-capsular enucleation. METHODS: We reviewed 36 schwannomas from 35 patients who underwent surgical excision of schwannomas arising from the extremities. Twenty had undergone extra-capsular resection and 16 had undergone enucleation using the intra-capsular technique. The post-operative neurological deficits were graded as minor, major, and transient. The duration of symptoms, maximum tumor diameter and site of occurrence were compared between patients with the three grades of deficit. RESULTS: In total, 22 patients developed no sensory changes following enucleation of schwannoma or only temporary and minor changes that had fully resolved within 6 months. Ten patients developed new neurological deficits following surgery that took longer than 6 months to resolve. Four patients experienced new motor deficits or paresthesia following operation that had still not recovered at the final follow-up, all of whom underwent enucleation using the extra-capsular technique. Neurological deficit after enucleation was significantly lower using the intra-capsular compared with the extra-capsular technique. Patient age, duration of symptoms, maximum diameter of the tumor and site of occurrence did not influence the neurological deficit following enucleation of schwannoma. CONCLUSION: These results support intra-capsular micro-enucleation as a safe and reliable treatment for every type of schwannoma. To minimize the risk of nerve injury, en bloc resection should not be used because the main purpose of schwannoma surgery is the relief of symptoms, not tumor resection. Thorough pre-operative counseling of patients to inform them of the potential occurrence of neurological deficit is important.


Assuntos
Microcirurgia/métodos , Neurilemoma/cirurgia , Procedimentos Neurocirúrgicos/métodos , Nervos Periféricos/cirurgia , Neoplasias do Sistema Nervoso Periférico/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Microcirurgia/efeitos adversos , Pessoa de Meia-Idade , Neurilemoma/patologia , Neurilemoma/fisiopatologia , Procedimentos Neurocirúrgicos/efeitos adversos , Nervos Periféricos/patologia , Nervos Periféricos/fisiopatologia , Neoplasias do Sistema Nervoso Periférico/patologia , Neoplasias do Sistema Nervoso Periférico/fisiopatologia , Estudos Retrospectivos , Adulto Jovem
14.
J Plast Reconstr Aesthet Surg ; 64(8): 1068-74, 2011 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-21474401

RESUMO

Wide resection of tumours in the anterior compartment of the thigh frequently requires en bloc removal of the quadriceps femoris muscle. Such resection can result in significantly decreased muscle power of knee extension. Functional muscle transfer is a beneficial tool for the reconstruction process. Until now, however, there have been few reports on the outcome of quadriceps muscle reconstruction using free innervated muscle transfer. We reviewed 14 patients (seven women and seven men, mean age 53 years). The extent of tumour invasion required resection of the entire quadriceps in four cases, of three heads in six cases and of two heads in the remaining four cases. Local recurrence occurred in one patient only, and there were no major complications. In the four patients with entire resection of the quadriceps, the postoperative muscle manual test (MMT) result was 0-1 (mean, 0.5), but this recovered to between 2 and 3 (mean 2.3) after a mean follow-up of 70 months. In the six cases with resection of three heads, the MMT test result was 2 and active knee extension recovered almost fully. Transfer of free, functional latissimus dorsi muscle is best indicated for cases in which the entire quadriceps or three heads are resected. Active knee extension can be expected to improve to an MMT score of 2 after reinnervation of the transferred muscle. Microsurgical reconstruction following resection of soft-tissue sarcoma provides adequate functional and coverage reconstruction, together with better local control by allowing wider surgical margins.


Assuntos
Neoplasias Ósseas/cirurgia , Músculo Esquelético/transplante , Músculo Quadríceps/cirurgia , Sarcoma/cirurgia , Neoplasias de Tecidos Moles/cirurgia , Idoso , Eletromiografia , Feminino , Humanos , Articulação do Joelho/fisiologia , Masculino , Pessoa de Meia-Idade , Amplitude de Movimento Articular/fisiologia
15.
J Perinatol ; 31(2): 146-8, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21283082

RESUMO

We herein report a case study of a female newborn with multiple pituitary hormone deficiencies who presented with generalized seizures, hypoglycemia and hyperammonemia at 18 h after birth. In addition, we review the association of hyperammonemia in neonates with multiple pituitary hormone deficiencies reported in the previous literature. This unrecognized association should be taken into account for the early diagnosis and treatment of these patients.


Assuntos
Hidrocortisona/administração & dosagem , Hiperamonemia/etiologia , Hipopituitarismo , Hipófise , Tiroxina/administração & dosagem , Esquema de Medicação , Monitoramento de Medicamentos , Feminino , Terapia de Reposição Hormonal , Humanos , Hidrocortisona/deficiência , Hipoglicemia/etiologia , Hipopituitarismo/complicações , Hipopituitarismo/congênito , Hipopituitarismo/diagnóstico , Hipopituitarismo/metabolismo , Hipopituitarismo/fisiopatologia , Hipopituitarismo/terapia , Recém-Nascido , Imageamento por Ressonância Magnética , Redes e Vias Metabólicas , Hipófise/anormalidades , Hipófise/metabolismo , Hipófise/fisiopatologia , Convulsões/etiologia , Tiroxina/deficiência , Resultado do Tratamento
16.
J Perinatol ; 31(4): 246-50, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-20706192

RESUMO

OBJECTIVE: The aim of this study was to assess the genetic effects of the vascular endothelial growth factor (VEGF) pathway on retinopathy of prematurity (ROP). STUDY DESIGN: A prospective study from a tertiary center that enrolled 204 Japanese infants (<35 weeks of gestational age (GA)) having no anomalies. ROP developed in 127, but not in 77 infants. The relative severity was defined as non-severe, moderate and severe ROP for GA, based on the staging criteria. VEGF (g.-634G>C, g.+13553C>T) and VEGF-receptor (KDR g.+4422(AC)11 to 14, Flt-1 c.+6724(TG)13 to 23) gene polymorphisms and clinical variables were assessed by uni/multivariate analyses. RESULT: The frequency of polymorphisms did not differ between ROP and non-ROP patients. The TT genotype of g.+13553 showed a higher odds ratio for non-severe ROP than CC genotype (P=0.006). Multivariate analyses indicated that low birth weight, blood transfusion and respiratory distress syndrome, but not polymorphisms, were the risk factors of advanced ROP (≥ stage 3). CONCLUSION: A genotype of the VEGF pathway weakly affects the severity of ROP compared with other clinical factors.


Assuntos
Recém-Nascido de Baixo Peso , Síndrome do Desconforto Respiratório do Recém-Nascido/complicações , Retinopatia da Prematuridade , Reação Transfusional , Receptor 1 de Fatores de Crescimento do Endotélio Vascular , Feminino , Genótipo , Idade Gestacional , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Masculino , Polimorfismo Genético , Nascimento Prematuro/fisiopatologia , Nascimento Prematuro/terapia , Estudos Prospectivos , Retinopatia da Prematuridade/complicações , Retinopatia da Prematuridade/genética , Retinopatia da Prematuridade/fisiopatologia , Fatores de Risco , Índice de Gravidade de Doença , Fator A de Crescimento do Endotélio Vascular
17.
J Dairy Sci ; 93(7): 2887-95, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20630206

RESUMO

The effects of whipping temperature (5 to 15 degrees C) on the whipping (whipping time and overrun) and rheological properties of whipped cream were studied. Fat globule aggregation (aggregation ratio of fat globules and serum viscosity) and air bubble factors (overrun, diameter, and surface area) were measured to investigate the mechanism of whipping. Whipping time, overrun, and bubble diameters decreased with increasing temperature, with the exception of bubble size at 15 degrees C. The aggregation ratio of fat globules tended to increase with increasing temperature. Changes in hardness and bubble size during storage were relatively small at higher temperatures (12.5 and 15 degrees C). Changes in overrun during storage were relatively small in the middle temperature range (7.5 to 12.5 degrees C). From the results, the temperature range of 7.5 to 12.5 degrees C is recommended for making whipped creams with a good texture, and a specific temperature should be decided when taking into account the preferred overrun. The correlation between the whipped cream strain hardness and serum viscosity was high (R(2)=0.906) and persisted throughout the temperature range tested (5 to 15 degrees C). A similar result was obtained at a different whipping speed (140 rpm). The multiple regression analysis in the range of 5 to 12.5 degrees C indicated a high correlation (R(2)=0.946) in which a dependent variable was the storage modulus of whipped cream and independent variables were bubble surface area and serum viscosity. Therefore, fat aggregation and air bubble properties are important factors in the development of cream hardness. The results of this study suggest that whipping temperature influences fat globule aggregation and the properties of air bubbles in whipped cream, which alters its rheological properties.


Assuntos
Laticínios , Manipulação de Alimentos/métodos , Temperatura , Laticínios/análise , Reologia , Fatores de Tempo , Viscosidade
18.
Int J Immunogenet ; 36(1): 65-8, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19207938

RESUMO

This study is to elucidate whether the B- and T-lymphocyte attenuator (BTLA) gene is a new susceptibility gene for the development of type 1 diabetes (T1D) and systemic lupus erythematosus (SLE). As a result, this study did not find any genetic contribution of the BTLA gene to the development of T1D and SLE in Japanese population.


Assuntos
Diabetes Mellitus Tipo 1/genética , Predisposição Genética para Doença , Lúpus Eritematoso Sistêmico/genética , Receptores Imunológicos/genética , Alelos , Linfócitos B/metabolismo , Criança , Frequência do Gene/genética , Genótipo , Haplótipos/genética , Humanos , Polimorfismo de Nucleotídeo Único/genética , Linfócitos T/metabolismo
19.
Br J Neurosurg ; 22(6): 790-2, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19085364

RESUMO

Intrasacral schwannoma is a very rare lesion. We report here three cases of intrasacral schwannoma originating within the sacrum and discuss their clinical presentation, diagnosis and management. Complete excision would appear to be the treatment of choice, but conservative treatment is an option provided the tumour causes no serious symptoms.


Assuntos
Neoplasias dos Nervos Cranianos/diagnóstico , Neurilemoma/diagnóstico , Sacro , Neoplasias da Coluna Vertebral/diagnóstico , Idoso , Nádegas , Neoplasias dos Nervos Cranianos/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Dor Lombar/etiologia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neurilemoma/cirurgia , Neoplasias da Coluna Vertebral/cirurgia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
20.
Arch Orthop Trauma Surg ; 128(1): 11-5, 2008 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17203284

RESUMO

Low-grade central osteosarcoma is an unusual variant of conventional osteosarcoma. We present here two rare cases of low-grade central osteosarcoma resembling fibrous dysplasia. A 24-year-old woman diagnosed as fibrous dysplasia was treated with intra-lesional excision and curettage of the tumor but tumor recurred at 4 months after surgery. Distal femoral en-bloc resection was performed followed by arthroplasty with mega-prosthesis of the knee. A 57-year-old man diagnosed as central osteosarcoma was treated with wide excision of the tumor, followed by reconstruction with the vascularized fibula graft combined with an autogenous irradiated bone graft. Because of the difficulty in distinguishing low-grade central osteosarcoma from a benign lesion, open biopsy is needed to obtain a large tumor sample. Careful clinical and pathological evaluation is required to obtain a definite diagnosis. The treatment of low-grade central osteosarcoma is en-block resection with wide surgical margins.


Assuntos
Neoplasias Ósseas/diagnóstico , Neoplasias Femorais/diagnóstico , Displasia Fibrosa Óssea/diagnóstico , Osteossarcoma/diagnóstico , Tíbia , Adulto , Neoplasias Ósseas/cirurgia , Diagnóstico Diferencial , Feminino , Neoplasias Femorais/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/patologia , Osteossarcoma/patologia , Osteossarcoma/cirurgia
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