RESUMO
We compared the effect of Xymedon (100 mg/kg), Mexidol (50 mg/kg), and their combination on spermatogenesis indicators and functional state of spermatozoa in rats with Walker-256 carcinoma treated with doxorubicin (4 mg/kg) and cyclophosphamide (45 mg/kg) (once intraperitoneally on day 11 after tumor cells transplantation). Xymedon and Mexidol were injected intramuscularly for 10 days starting from day 11 of the experiment. The studied parameters were evaluated on experimental days 14 and 21. We have established that gonadoprotective effect of Xymedon developed gradually and persisted longer than that of Mexidol. It manifested in an increase in the number of epithelial spermatogenesis cells (spermatogonia by 3.2 times, early spermatids by 2.2 times, late spermatids by 2.9 times, and Leydig cells by 4 times) in the testes and also the proportion of viable progressively and non-progressively motile epididymal spermatozoa (by 2 times). The combination of Xymedon and Mexidol stimulated spermatogenesis (with restoration of the initial level of spermatocytes, an increase in the number of early spermatids by 65.5 and 99% in comparison with Xymedon alone and Mexidol alone, respectively) and increased the number of viable epididymal spermatozoa more effectively than Xymedon and Mexidol alone by 54 and 60%, respectively.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma 256 de Walker/tratamento farmacológico , Espermatogênese/efeitos dos fármacos , Animais , Carcinoma 256 de Walker/patologia , Carcinoma 256 de Walker/fisiopatologia , Ciclofosfamida/administração & dosagem , Doxorrubicina/administração & dosagem , Masculino , Picolinas/administração & dosagem , Pirimidinas/administração & dosagem , Ratos , Ratos Wistar , Análise do Sêmen , Espermatozoides/efeitos dos fármacos , Espermatozoides/patologia , Espermatozoides/fisiologiaRESUMO
The possibility of correction of morphological changes in the myocardium and biochemical parameters of the blood with 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg was studied in the model of doxorubicin-induced chronic heart failure in rats. It was found that 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg produced less pronounced cardio-protective effect in experimental chronic heart failure than 3-hydroxypyridine succinate.
Assuntos
Acetilcisteína/farmacologia , Antioxidantes/farmacologia , Cardiotônicos/farmacologia , Insuficiência Cardíaca/prevenção & controle , Picolinas/farmacologia , Piridinas/farmacologia , Acetilcisteína/análogos & derivados , Alanina Transaminase/sangue , Animais , Antibióticos Antineoplásicos/toxicidade , Antioxidantes/síntese química , Cardiotônicos/síntese química , Catalase/sangue , Creatina Quinase Forma MB/sangue , Doxorrubicina/antagonistas & inibidores , Doxorrubicina/toxicidade , Coração/efeitos dos fármacos , Coração/fisiopatologia , Insuficiência Cardíaca/induzido quimicamente , Insuficiência Cardíaca/fisiopatologia , Injeções Intraperitoneais , Malondialdeído/antagonistas & inibidores , Malondialdeído/sangue , Potássio/sangue , Piridinas/química , Ratos , Ureia/sangueRESUMO
We studied the cardioprotective properties of mexidol and 3-hydroxypyridine fumarate in rat model of chronic myocardial injury. We found that 3-hydroxypyridine fumarate (25 mg/kg) produced more pronounced antioxidant and cardioprotective effects than mexidol (25 mg/kg).
Assuntos
Insuficiência Cardíaca/tratamento farmacológico , Picolinas/uso terapêutico , Piridinas/uso terapêutico , Animais , Antioxidantes/uso terapêutico , Aspartato Aminotransferases/sangue , Metabolismo Energético/efeitos dos fármacos , Malondialdeído/sangue , Miócitos Cardíacos/efeitos dos fármacos , Miócitos Cardíacos/metabolismo , Inibidores da Agregação Plaquetária/uso terapêutico , Potássio/sangue , RatosRESUMO
Cardioprotective effects of derivatives of 3-hydroxypyridine, benzimidazole, and a peptide substance were studied on the model of combined damage to the myocardium (catecholamines and physical exercises) in mice. The most pronounced antioxidant and cardioprotective effects were produced by 3-hydroxypyridine acetylcysteinate (50 mg/kg), benzimidazole derivative Be-2m (50 mg/kg), and peptide substance γ-glutamyl histamine (1 mg/kg).
Assuntos
Antioxidantes/farmacologia , Benzimidazóis/química , Cardiomiopatias/prevenção & controle , Cardiotônicos/farmacologia , Oligopeptídeos/química , Piridinas/química , Animais , Antioxidantes/química , Cálcio/sangue , Cardiotônicos/administração & dosagem , Creatina Quinase/sangue , Injeções Intramusculares , Camundongos , Condicionamento Físico Animal , Potássio/sangue , Fatores de TempoRESUMO
We studied the interaction of mexidol and 3-hydroxypyridine acetylcysteinate on the model of experimental ischemic stroke in rats. The preparations were effective in a dose 50 mg/kg (10-day treatment): they reduced the incidence of neurological disturbances (pareses, sensitivity disturbances) and improved antioxidant defense of the plasma.
Assuntos
Acetilcisteína/farmacologia , Isquemia Encefálica/prevenção & controle , Diabetes Mellitus Experimental/complicações , Hipercolesterolemia/complicações , Fármacos Neuroprotetores/farmacologia , Picolinas/farmacologia , Acetilcisteína/análogos & derivados , Acetilcisteína/uso terapêutico , Animais , Isquemia Encefálica/complicações , Feminino , Masculino , Fármacos Neuroprotetores/uso terapêutico , Picolinas/uso terapêutico , Ratos , Resultado do TratamentoRESUMO
The authors have studied hepatoprotective actions of new derivatives of 3-hydroxipyridine on an experimental model of toxic hepatitis (140 white mice). Mexidol and berlithion are choosed as the preparations of comparison. The method of light microscopy is used for the exploration of morphological changes. The cytolytic contents activity, catalase activity and the level of MDA have been determined in blood serum. The antitoxic effect is valued by the survival of the animals. It is found that all examined bonds is corrected morphological changes in toxic hepatitis and increased the index of animals survival, which is more expressed than the preparations of comparison.
Assuntos
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico , Picolinas/uso terapêutico , Substâncias Protetoras/uso terapêutico , Animais , Tetracloreto de Carbono/toxicidade , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Doença Hepática Induzida por Substâncias e Drogas/metabolismo , Doença Hepática Induzida por Substâncias e Drogas/patologia , Modelos Animais de Doenças , Feminino , Testes de Função Hepática , Masculino , Malondialdeído/sangue , Camundongos , Picolinas/administração & dosagem , Substâncias Protetoras/administração & dosagemRESUMO
Mexidol therapy inhibited cyclophosphamide-induced myelosuppression in C57B1/6 line mice with Lewis lung carcinoma without affecting antitumor action of the latter. Mexidol plus cyclophosphamide proved more effective in prophylaxis of metastasis as compared with the cytostatic alone.
Assuntos
Antineoplásicos/farmacologia , Medula Óssea/efeitos dos fármacos , Carcinoma Pulmonar de Lewis/tratamento farmacológico , Ciclofosfamida/efeitos adversos , Ciclofosfamida/farmacologia , Picolinas/farmacologia , Animais , Antineoplásicos Alquilantes/efeitos adversos , Antineoplásicos Alquilantes/farmacologia , Carcinoma Pulmonar de Lewis/sangue , Carcinoma Pulmonar de Lewis/patologia , Eritrócitos/efeitos dos fármacos , Hemoglobinas/efeitos dos fármacos , Leucócitos/efeitos dos fármacos , Linfócitos/efeitos dos fármacos , Camundongos , Camundongos Endogâmicos C57BL , Agonistas Mieloablativos/efeitos adversos , Agonistas Mieloablativos/farmacologia , Neutrófilos/efeitos dos fármacosRESUMO
The authors have studied mexicor's efficacy in a comprehensive treatment of 25 patients suffering from atherosclerosis obliterans of the lower extremities with grade II-III ischaemia. The state of the vascular bed and the degree of arteries' narrowing were assessed by means of colour duplex scanning of the lower limb arteries using the unit Vivid 7 manufactured by the Company <
Assuntos
Arteriosclerose Obliterante/tratamento farmacológico , Perna (Membro)/irrigação sanguínea , Piridinas/administração & dosagem , Angiografia , Arteriosclerose Obliterante/diagnóstico por imagem , Seguimentos , Humanos , Infusões Intravenosas , Masculino , Pessoa de Meia-Idade , Pletismografia de Impedância , Resultado do Tratamento , Ultrassonografia Doppler DuplaRESUMO
On model of experimental diabetes in rats the possibility of correction of impairments of lipid, carbohydrate and albumin metabolism by SEMOP in a dose of 25 or 5 mg/kg, dimephosphone (100 mg/kg) and alpha-tocopherol (25 mg/kg) has been Advantage of SEMOP consists in its ability to decrease a level of total protein and albumin of blood of animals with experimental diabetes.
Assuntos
Antioxidantes/uso terapêutico , Diabetes Mellitus Experimental/tratamento farmacológico , Albuminas/metabolismo , Animais , Metabolismo dos Carboidratos , Diabetes Mellitus Experimental/metabolismo , Feminino , Metabolismo dos Lipídeos , Peroxidação de Lipídeos , Masculino , RatosAssuntos
Grupo dos Citocromos c/farmacologia , Hipocinesia/metabolismo , Peroxidação de Lipídeos/efeitos dos fármacos , Adaptação Biológica/efeitos dos fármacos , Animais , Aorta/patologia , Arteriosclerose/etiologia , Arteriosclerose/patologia , Chinchila , Grupo dos Citocromos c/administração & dosagem , Eletrocardiografia , Eritrócitos/enzimologia , Seguimentos , Glutationa Peroxidase/sangue , Hipocinesia/complicações , Hipocinesia/tratamento farmacológico , Imobilização/efeitos adversos , Infusões Intravenosas , Masculino , Malondialdeído/sangue , Infarto do Miocárdio/etiologia , Infarto do Miocárdio/patologia , Infarto do Miocárdio/fisiopatologia , Coelhos , Superóxido Dismutase/sangueRESUMO
It was shown in rabbit experiments that the use of ximedon in long-term immobilization stress limits activation of lipid peroxidation, stimulates the main enzymes of the antioxidant systems, causes of hypolipidemic, preventive endotheliotropic, and cardiotropic effect.
Assuntos
Adaptação Fisiológica/efeitos dos fármacos , Pirimidinas/farmacologia , Estresse Psicológico/tratamento farmacológico , Animais , Doença Crônica , Avaliação Pré-Clínica de Medicamentos , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Pirimidinas/uso terapêutico , Coelhos , Restrição Física , Estresse Psicológico/sangue , Estresse Psicológico/fisiopatologia , Fatores de TempoRESUMO
The rabbit experiment has studied the impact of ultraviolet (UV) blood irradiation on the course of adaptative processes under restrictive stress. Thirty-day hypodynamia was demonstrated to result in chronic stress whose pathogenetic links are activated neutrophilic leukocytes, developed disseminated intravascular coagulation, atherogenic metabolic changes. UV blood irradiation enhanced the body's adaptative potentialities under long-term hypodynamia, by diminishing restriction-induced stress lesion.
Assuntos
Adaptação Fisiológica/efeitos da radiação , Hipocinesia/sangue , Raios Ultravioleta , Animais , Sangue/efeitos da radiação , Masculino , CoelhosRESUMO
Experiments on 50 rabbits examined the hemostatic effects of negative oxygen aeroions (AI). In control experiments, keeping the animals under hypodynamia led to 40% animal death, significant aortic atherosclerosis and myocardial infarction. The animals developed the thrombohemorrhagic syndrome with hypercoagulemia and drastically suppressed blood fibrinolytic activity. Keeping the animals in the excess AI-containing premise saved all rabbits' life and prevented arteriosclerosis and myocardial infarction. Unlike the controls, these animals failed to develop the thrombohemorrhagic syndrome. Clotting time, plasma recalcification time, and plasma silicon and kaolin time did not reduce, but prolonged. There was no drop in the content of antithrombin III or rise in values of paracoagulation tests. It is recommended that Chizhevsky's electroeffluvial chandeliers should be used to prevent hemostatic disorders and arteriosclerosis in hypodynamia.
Assuntos
Arteriosclerose/prevenção & controle , Hemostasia/efeitos dos fármacos , Hipocinesia/complicações , Oxigênio/farmacologia , Animais , Ânions/farmacologia , Arteriosclerose/etiologia , Masculino , CoelhosRESUMO
Adaptation to exercises was studied in rabbits exposed to restriction stress. Transition from 30-day inactivity to the routine motor activity and subsequent exercises was found to cause a further progression of blood atherogenic changes, ulcerative arteriosclerosis, and heart failure.
Assuntos
Adaptação Fisiológica/fisiologia , Arteriosclerose/etiologia , Hipocinesia/complicações , Lipídeos/sangue , Estresse Fisiológico/complicações , Animais , Arteriosclerose/sangue , Arteriosclerose/patologia , Chinchila , Eletrocardiografia , Hipocinesia/sangue , Hipocinesia/fisiopatologia , Masculino , Atividade Motora , Esforço Físico , Coelhos , Estresse Fisiológico/sangue , Estresse Fisiológico/fisiopatologiaRESUMO
The effect of hypokinesia on the hemocoagulatory and fibrinolytic properties of aorta, myocardium and venae cavae was studied. Hypokinesia decreased thromboplastic activity of the intima and increased that of the mid- and outer layers of the aorta. Anticoagulatory properties of aortal and myocardial tissues increased whereas their antithrombin properties decreased. Rabbit immobilization increased the content of fibrinolytic stimulants in the aorta and myocardium.