RESUMO
BACKGROUND: Oral alendronate, risedronate, and raloxifene are effective treatment options in the management of postmenopausal osteoporosis. There is little previously reported about the renal safety profiles of these three agents in osteoporosis. We aimed to assess the risk of renal toxicity associated with oral alendronate, risedronate, and raloxifene in the treatment of osteoporosis, prospectively. METHODS: One hundred and twenty-seven patients with osteoporosis and osteopenia according to lumbar or femoral-neck bone mineral density t score were enrolled in the study. The patients were randomized to alendronate 70 mg once weekly (n = 47), risedronate 35 mg once weekly (n = 44), or raloxifene 60 mg per day (n = 36) for one year. Preliminary screening included medical history, physical examination, lumbar and femoral bone mineral densitometry measurement, and blood biochemical tests, including renal function tests. The biochemical markers were then assessed at the end of 12 months. RESULTS: There was no significant difference between basal and final renal function parameters of each group. Also these parameters did not differ between the three groups after 12 months of treatment period. CONCLUSIONS: These results demonstrate that alendronate, risedronate, and raloxifene are all safe drugs for renal functions in the treatment of osteoporosis.
Assuntos
Alendronato/farmacologia , Conservadores da Densidade Óssea/farmacologia , Ácido Etidrônico/análogos & derivados , Rim/efeitos dos fármacos , Cloridrato de Raloxifeno/farmacologia , Idoso , Proteína C-Reativa/análise , Cálcio/sangue , Ácido Etidrônico/farmacologia , Feminino , Humanos , Testes de Função Renal , Masculino , Pessoa de Meia-Idade , Osteoporose Pós-Menopausa/tratamento farmacológico , Osteoporose Pós-Menopausa/fisiopatologia , Fósforo/sangue , Ácido Risedrônico , Ácido Úrico/sangueRESUMO
Untreated asymptomatic bacteriuria has been associated with acute pyelonephritis, which may have a role in many maternal and fetal complications. Acute pyelonephritis in pregnancy is related to anemia, septicemia, transient renal dysfunction, and pulmonary insufficiency. A randomized study was conducted to assess the clinical and microbiological efficacy of a single dose of fosfomycin trometamol for the treatment of asymptomatic bacteriuria in the second trimester of pregnancy compared with a 5-day regimen of cefuroxime axetyl. Forty-four women received fosfomycin trometamol and 40 women received cefuroxime axetyl. There were no statistically significant differences between both groups regarding the mean age and mean duration of pregnancy. Therapeutic success was achieved in 93.2% of the patients treated with fosfomycin trometamol vs 95% of those treated with cefuroxime axetyl. A single dose of fosfomycin trometamol is a safe and effective alternative in the treatment of asymptomatic urinary tract infections in the second trimester of pregnancy.
Assuntos
Antibacterianos/administração & dosagem , Bacteriúria/tratamento farmacológico , Fosfomicina/administração & dosagem , Complicações Infecciosas na Gravidez/tratamento farmacológico , Segundo Trimestre da Gravidez , Adulto , Fatores Etários , Cefuroxima/administração & dosagem , Cefuroxima/análogos & derivados , Esquema de Medicação , Infecções por Escherichia coli/tratamento farmacológico , Feminino , Humanos , Gravidez , Segurança , Método Simples-Cego , Resultado do TratamentoRESUMO
Antiphospholipid syndrome (APS) is an autoimmune disorder associated with either arterial and/or venous thrombosis (1). Two cases of APS, which were diagnosed in the second trimester during the diagnostic workup of fetal bradycardia, are presented.
Assuntos
Síndrome Antifosfolipídica/complicações , Síndrome Antifosfolipídica/diagnóstico , Bradicardia/complicações , Bradicardia/diagnóstico , Doenças Fetais/diagnóstico , Adulto , Feminino , Humanos , Gravidez , Segundo Trimestre da GravidezRESUMO
Myxedematous coma in pregnancy is a rare incident. We present a case of Myxedematous coma in a laboring woman that suggested a pre-eclamptic coma and finalized with a healthy baby.
Assuntos
Coma/etiologia , Mixedema/diagnóstico , Complicações do Trabalho de Parto/diagnóstico , Pré-Eclâmpsia/diagnóstico , Diagnóstico Pré-Natal , Adulto , Diagnóstico Diferencial , Feminino , Número de Gestações , Humanos , Recém-Nascido , Mixedema/complicações , Pré-Eclâmpsia/complicações , GravidezRESUMO
Acardiac twins are usually diagnosed during the antenatal period and almost invariably cause complications to the other fetus. In this case, an acardiac twin pregnancy was misdiagnosed antenatally as a degenerated myoma but ended with delivery of a healthy baby.