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2.
Infect Genet Evol ; 25: 93-6, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24747608

RESUMO

Cholera has been a recurrent epidemic disease in human populations for the past 200years. We present herein a comparative characterization of clinical Vibrio cholerae strains isolated from two consecutive cholera outbreaks in 2012 and associated environmental strains from western India. The clinical and toxigenic environmental isolates were identified as hybrid V. cholerae O1, serotype Ogawa, biotype El Tor carrying the variant ctxB7 allele. Partial sequences of SXT integrase from the isolates revealed 100% identity to ICEVchInd5 (Sevagram, India, 1994) and VC1786ICE (Haiti, 2013). The full clonal relationship of the strains established by RAPD, Box PCR, ERIC PCR and MLST (pyrH, recA and rpoA) analyses, and the short time between the two outbreaks, strongly supported that both outbreaks were due to a single strain. The study corroborated that faecal contamination of the potable water supply was the main reason for the first outbreak, which further spread to other areas and resulted in the second outbreak. The study concluded that the circulating El Tor variant strains of epidemic potential in the region can be a serious concern in the future.


Assuntos
Proteínas de Bactérias/genética , Cólera/epidemiologia , Água Potável/microbiologia , Integrases/genética , Vibrio cholerae O1/classificação , Vibrio cholerae O1/isolamento & purificação , Cólera/microbiologia , Surtos de Doenças , Humanos , Índia/epidemiologia , Tipagem de Sequências Multilocus , Filogenia , Análise de Sequência de DNA , Vibrio cholerae O1/genética
3.
Clin Microbiol Infect ; 20(5): O292-3, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24102849

RESUMO

Vibrio cholerae O1 biotype El Tor producing Haitian variant Cholera Toxin (HCT) and showing reduced susceptibility to ciprofloxacin caused a cholera outbreak associated with a high case fatality rate (4.5) in India. HCT-secreting strains responsible for severe cholera epidemics in Orissa (India), Western Africa and Haiti were associated with increased mortality. There is a pressing need for an integrated multidisciplinary approach to combat further spread of newly emerging variant strains. The therapeutic effect of ciprofloxacin was diminished whereas use of doxycycline in moderate to severe cholera patients was found to be effective in outbreak management.


Assuntos
Proteínas de Bactérias/genética , Cólera/epidemiologia , Cólera/microbiologia , Surtos de Doenças , Vibrio cholerae O1/efeitos dos fármacos , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Cólera/tratamento farmacológico , Toxina da Cólera/genética , Ciprofloxacina/farmacologia , DNA Girase/genética , DNA Topoisomerase IV/genética , Testes de Sensibilidade a Antimicrobianos por Disco-Difusão , Doxiciclina/uso terapêutico , Farmacorresistência Bacteriana/genética , Humanos , Índia/epidemiologia , Vibrio cholerae O1/genética
5.
Indian J Pathol Microbiol ; 41(4): 419-22, 1998 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-9866901

RESUMO

V. cholerae 01 E1 Tor isolated during Cholera epidemic of 1994 and V cholerae 0139 serotype isolated during 1993 epidemic were subjected to the study of proteases and other enzymes. Out of 26 strains of V. cholerae 01 studied, gelatinase and caseinase activity was seen in 100 and 69.23 percent strains respectively. All strains showed catalase and oxidase activity. Of the other enzymes studied 19.23, 65.38 and 57.69 percent strains were positive for DNAse, lipase and phosphatase respectively. None of the strains showed lecithinase activity. Similar findings were observed in 22 strains of V. cholerae 0139 except all strains were positive for phosphatase activity. Role of enzymes in virulence is suggested.


Assuntos
Proteínas de Bactérias/metabolismo , Endopeptidases/metabolismo , Vibrio cholerae/enzimologia , Humanos
6.
Indian J Med Res ; 108: 1-2, 1998 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-9745210

RESUMO

A clone of V. cholerae serogroup O139 which emerged as a novel epidemic strain, was reported from this region in 1993 as from many other parts of India and adjoining countries. The decline in the isolation rate of this organism in subsequent years was followed by a sudden increase in 1997, this requires careful monitoring.


Assuntos
Vibrio cholerae/isolamento & purificação , Índia , Sorotipagem , Fatores de Tempo , Vibrio cholerae/classificação
8.
Indian J Pathol Microbiol ; 40(3): 369-71, 1997 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-9354010

RESUMO

During 1992, 1993 and 1994 a total of 65, 123 and 142 faecal samples respectively yielded 9, 54 and 87 strains of V. cholerae. Simultaneous occurrence of EL TOR vibrio and non 01 (i.e. 0139) was noted during 1993 and 1994 with variations in relative and absolute prevalence of each serotype. Seasonal incidence is fairly consistent in this region. Both V. cholerae serotypes 01 and 0139 showed resistance to one or more drugs.


Assuntos
Cólera/epidemiologia , Cólera/microbiologia , Vibrio cholerae/isolamento & purificação , Surtos de Doenças , Resistência Microbiana a Medicamentos , Humanos , Índia/epidemiologia , Sorotipagem , Fatores de Tempo , Vibrio cholerae/classificação , Vibrio cholerae/efeitos dos fármacos
9.
Indian J Med Res ; 103: 74-6, 1996 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-8714142

RESUMO

Thirty three patients presented with acute diarrhoea and vomiting, 12-24 h after consuming vegetarian food. Twenty three patients developed high grade fever, with two patients developing complications. Salmonella paratyphi A var durazzo was isolated from 12 faecal samples. This serovar of Salmonella as a causative organism of food poisoning is unusual.


Assuntos
Surtos de Doenças , Intoxicação Alimentar por Salmonella/epidemiologia , Salmonella paratyphi A/isolamento & purificação , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Índia/epidemiologia , Lactente , Masculino
11.
Indian J Med Sci ; 49(10): 231-2, 1995 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-8772827

RESUMO

A case of primary cutaneous nocardiosis on abdominal wall, caused by Nocardia asterides is reported here. The site and the organism are both rarely encountered. The patient responded to sulphonamide treatment.


Assuntos
Nocardiose/diagnóstico , Nocardia asteroides , Dermatopatias Bacterianas/diagnóstico , Adulto , Humanos , Masculino
12.
Indian J Med Res ; 101: 62-3, 1995 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-7729850

RESUMO

A total of 65 strains of V. cholerae were isolated during June-July 1994 at Yavatmal (Maharashtra). Of the 65 strains isolated, 62 were 01 El Tor Vibrios, while three were non 01 serotype 0139. The novel epidemic strain designated as 0139 reported during the outbreak in 1993, has been supplanted by the usual El Tor Vibrio during the present outbreak while 0139 serotype has remained sporadic.


Assuntos
Cólera/epidemiologia , Surtos de Doenças , Cólera/microbiologia , Humanos , Índia/epidemiologia , Vibrio cholerae/isolamento & purificação
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