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1.
Cardiovasc J Afr ; 23(6): e16-8, 2012 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-22832480

RESUMO

Tricuspid annular ventricular tachycardia (VT) is a rarely encountered entity. Despite abundant data on idiopathic VTs, the prevalence and clinical characteristics of this infrequent form are not well defined and the efficacy of radiofrequency (RF) catheter ablation treatment remains unknown. We report on a case of a 44-year-old male presenting with symptomatic sustained idiopathic VT originating from the posteroseptal tricuspid annulus.


Assuntos
Taquicardia Ventricular/etiologia , Valva Tricúspide/fisiopatologia , Adulto , Bloqueio de Ramo/etiologia , Ablação por Cateter , Eletrocardiografia , Técnicas Eletrofisiológicas Cardíacas , Humanos , Masculino , Taquicardia Ventricular/diagnóstico , Taquicardia Ventricular/fisiopatologia , Taquicardia Ventricular/cirurgia , Resultado do Tratamento
2.
Clin Cardiol ; 33(7): E43-5, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20641111

RESUMO

Woven coronary artery is an extremely rare and is still not a clearly defined coronary anomaly in which epicardial coronary artery is divided into multiple thin channels at any segment of the coronary artery, and subsequently, these multiple channels merge again in a normal conduit. A few cases have been reported till now. In this case report, we present a 58-year-old male with a woven right coronary artery.


Assuntos
Anomalias dos Vasos Coronários/diagnóstico , Fármacos Cardiovasculares/uso terapêutico , Angiografia Coronária , Circulação Coronária , Anomalias dos Vasos Coronários/diagnóstico por imagem , Anomalias dos Vasos Coronários/tratamento farmacológico , Anomalias dos Vasos Coronários/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
4.
J Thromb Thrombolysis ; 29(3): 310-5, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-19495941

RESUMO

We tested the hypothesis that increased platelet activation may be present in patients with slow coronary flow (SCF) and may contribute to the pathogenesis of slow coronary flow phenomenon (SCFP). Fifty patients angiographically proven normal coronary flow (control group; mean age = 61.3 +/- 7.0 years, 43 male) and 50 patients with angiographically proven SCF in all coronary arteries (patient group; man age = 62.7 +/- 6.7 years, 38 male) were included in the present study. Coronary flow rates of all subjects were documented by Thrombolysis In Myocardial Infarction frame count (TIMI frame count). Patients with a corrected TIMI frame count greater than two standard deviations from normal published range for the particular vessel were considered as having SCF. Complete blood count and mean platelet volume (MPV) was measured from whole blood sample with Abbott Cell-Dyne 4000 cell counter. Plasma sP-selectin concentrations were analyzed with sP-Selectin ELISA kit. There were no statistically significant differences between the two groups with respect to baseline demographic, clinical and lipid parameters. Not only MPV values but also plasma sP-selectin levels were significantly higher in patients with the patients with SCF compared to those of controls (for MPV; 8.2 +/- 0.7 vs. 7.2 +/- 0.6 fl, P < 0.001, for sP-Selectin; 1.5 +/- 0.3 vs. 1.0 +/- 0.2 ng/ml, P < 0.001). Interestingly, significant positive correlations were detected between mean TIMI frame counts and MPV and sP-selectin levels (for MPV; r = 0.56, P < 0.001, for sP-selectin r = 0.67, P < 0.001). The current study demonstrates that platelet activity is increased in the patients with SCF compared to that of the patients with normal coronary flow.


Assuntos
Circulação Coronária/fisiologia , Vasos Coronários/fisiologia , Ativação Plaquetária/fisiologia , Fluxo Sanguíneo Regional/fisiologia , Idoso , Angiografia Coronária/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
8.
Int J Cardiol ; 138(1): e15-7, 2010 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-18662833

RESUMO

Takotsubo cardiomyopathy is characterized by acute ventricular dysfunction in the absence of coronary obstruction. Complete improvement of ventricular function is seen in the vast majority of the patients. We describe a 40-year-old woman with Addison disease who experienced Takotsubo cardiomyopathy but with persistent apical dysfunction during 5-month-follow up.


Assuntos
Doença de Addison/complicações , Tomografia por Emissão de Pósitrons , Ventriculografia com Radionuclídeos , Cardiomiopatia de Takotsubo/complicações , Cardiomiopatia de Takotsubo/diagnóstico por imagem , Adulto , Progressão da Doença , Feminino , Humanos
9.
Int J Cardiol ; 138(1): 100-1, 2010 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-18667249

RESUMO

Stent strut fracture (SSF) may be an important complication after drug-eluting stent (DES) implantation particularly in patients undergoing sirolimus-eluting stent (SES) implantation. The occurrence of SSF at 6 to 9 months after the SES implantation, which was relatively common, resulted in a higher rate of focal in-stent restenosis. Although this angiographic unfavorable outcome did not lead to an increased risk of adverse cardiac events in the current study, we believe that large-scale prospective studies are needed to elucidate the exact pathophysiology and clinical sequela of the stent strut fracture, including bare metal stents.


Assuntos
Doença das Coronárias/terapia , Reestenose Coronária/etiologia , Stents Farmacológicos/efeitos adversos , Doença das Coronárias/fisiopatologia , Reestenose Coronária/fisiopatologia , Humanos
10.
Am J Hypertens ; 22(12): 1270-5, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19779469

RESUMO

BACKGROUND: Prolonged P-wave duration (P(dur)) and increased P-wave dispersion (PWD) are independent predictors of atrial fibrillation (AF) in patients with hypertension. This study was designed to evaluate the possible relationship between aortic elasticity and PWD in young prehypertensive patients. METHODS: Twenty-five newly diagnosed prehypertensive patients (18 men, mean age = 34 +/- 6 years) and 25 healthy control subjects (16 men, mean age = 33 +/- 6 years) were enrolled in the study. The P(dur) measurements were calculated using a 12-lead surface electrocardiogram (ECG). Aortic elasticity parameters were derived from aortic diameters measured by echocardiography, and simultaneous blood pressure (BP) measurements by sphygmomanometry. RESULTS: The baseline characteristics of patients with prehypertension were homogeneous with those of the controls. PWD and P(maximum) values were found to be higher in patients with prehypertension as compared to those of the controls (PWD; 65 ms vs. 35 ms, P < 0.001; P(maximum); 110 ms vs. 80 ms, P < 0.001). However, P(minimum) values were not significantly different between the two groups (40 ms vs. 45 ms, P = 0.358). Also, a moderate positive correlation was found between stiffness index (SI) and PWD (r = 0.500, P = 0.011), and a moderate negative correlation between aortic elasticity parameters (aortic distensibility and strain indexes) and PWD (for aortic distensibility, r = -0.498, P = 0.011; for strain index, r = -0.578, P = 0.002), in patients with prehypertension. CONCLUSIONS: Young patients with prehypertension have increased PWD and arterial stiffness. These parameters are correlated and may pose additional risk factors for future cardiovascular events.


Assuntos
Aorta/fisiopatologia , Elasticidade , Eletrocardiografia , Hipertensão/fisiopatologia , Adulto , Feminino , Humanos , Masculino
11.
Med Sci Monit ; 15(7): PI41-5, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19564839

RESUMO

BACKGROUND: Inflammation plays an important role in hypertension and in atherosclerosis. Inflammatory changes induced even in prehypertensive subjects can lead to increased arterial stiffness. The effects of perindopril on both inflammatory and aortic elasticity markers were tested in hypertensive patients. MATERIAL/METHODS: One hundred nine hypertensive patients not taking any antihypertensive therapy were included in the study. Aortic strain, aortic distensibility, aortic stiffness index, and inflammatory markers, including CRP, IL-1alpha IL-1beta, and TNF-alpha, were measured in all patients before and after twenty weeks of perindopril therapy. RESULTS: While aortic strain and distensibility showed statistically significant increases with perindopril therapy, the aortic stiffness index and inflammatory markers were found to decrease. CONCLUSIONS: Perindopril therapy resulted in an improvement in aortic elastic properties. There was also an attenuation of inflammatory status of the patients as reflected by lower inflammatory marker levels compared with pretreatment values.


Assuntos
Aorta/fisiopatologia , Elasticidade/efeitos dos fármacos , Hipertensão/tratamento farmacológico , Hipertensão/fisiopatologia , Inflamação/metabolismo , Perindopril/farmacologia , Perindopril/uso terapêutico , Anti-Hipertensivos/farmacologia , Anti-Hipertensivos/uso terapêutico , Aorta/efeitos dos fármacos , Biomarcadores/metabolismo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
13.
Yonsei Med J ; 50(6): 852-5, 2009 Dec 31.
Artigo em Inglês | MEDLINE | ID: mdl-20046430

RESUMO

Coronary-subclavian steal through the left internal mammary graft is a rare cause of myocardial ischemia in patients who have had a coronary bypass surgery. We report a 70-year-old man who presented with sustained monomorphic ventricular tachycardia 5 years after the surgical creation of a left internal mammary to the left anterior descending artery. Cardiac catheterization illustrated that the left subclavian artery was occluded proximally and that the distal course was visualized by retrograde filling through the left internal mammary graft. Clinical ventricular tachycardia was reproducibly induced with a single ventricular extrastimulus, and antitachycardia pacing terminated the tachycardia. Restoration of blood flow by way of a Dacron graft placed between the descending aorta and the subclavian artery resulted in the total relief of symptoms. Ventricular tachycardia could not be induced during the control electrophysiologic study after surgical revascularization.


Assuntos
Doença da Artéria Coronariana/diagnóstico , Doença da Artéria Coronariana/patologia , Síndrome do Roubo Subclávio/diagnóstico , Síndrome do Roubo Subclávio/patologia , Taquicardia Ventricular/patologia , Idoso , Ponte de Artéria Coronária/efeitos adversos , Doença da Artéria Coronariana/etiologia , Humanos , Masculino , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/etiologia , Síndrome do Roubo Subclávio/etiologia
15.
Int J Cardiol ; 132(2): 263-4; author reply 264-5, 2009 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-17651829

RESUMO

The distribution of body fat appears to be an important determinant as patients with abdominal obesity are at greatest cardiovascular risk. Also abdominal obesity is more predictive of coronary risk than simple body mass. On the other hand, weight gain after age 18 increases cardiovascular risk even in patients with normal body mass index. We believe that providing a healthy lifestyle, including dietary and physical activity modification, especially in early adolescence may play an essential part in the battle against atherosclerosis.


Assuntos
Aterosclerose/etiologia , Obesidade/complicações , Aumento de Peso , Abdome , Adolescente , Fatores Etários , Humanos
17.
Int J Cardiol ; 131(2): 267-8; author reply 268-9, 2009 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-17692411

RESUMO

No clear and generally accepted definition of clopidogrel resistance has been achieved up to now. We believe that the new point-of-care assays of platelet function may help the clinicians to overcome to define clopidogrel resistance especially in patients undergoing percutaneous coronary intervention in whom the level of inhibition of platelets is clinically essential.


Assuntos
Doenças Cardiovasculares/diagnóstico , Resistência a Medicamentos/fisiologia , Ticlopidina/análogos & derivados , Clopidogrel , Diagnóstico Diferencial , Humanos , Testes de Função Plaquetária/tendências , Sistemas Automatizados de Assistência Junto ao Leito/tendências , Ticlopidina/sangue , Ticlopidina/uso terapêutico
18.
Int J Cardiol ; 131(2): 269-70; author reply 271-2, 2009 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-17692947

RESUMO

Given the results of the BARI and ARTS I trials and a meta-analysis, coronary artery bypass surgery has been preferred to percutaneous coronary intervention in diabetics with multivessel coronary artery disease requiring hypoglycemic treatment and in whom internal mammary artery grafts can be used. This approach was strongly recommended in a 2002 ACC/AHA Task Force on the management of patients with acute coronary syndrome. But, these recommendations were made before the availability of drug-eluting stents. We strongly believe that the ongoing, multi-centre FREEDOM, CARDia and SYNTAX trials will elucidate the optimal revascularization strategy for diabetic patients with multivessel disease in the near future.


Assuntos
Doença da Artéria Coronariana/terapia , Complicações do Diabetes/terapia , Revascularização Miocárdica/métodos , Revascularização Miocárdica/tendências , Angioplastia Coronária com Balão/métodos , Angioplastia Coronária com Balão/tendências , Ensaios Clínicos como Assunto/métodos , Ensaios Clínicos como Assunto/tendências , Ponte de Artéria Coronária/métodos , Ponte de Artéria Coronária/tendências , Doença da Artéria Coronariana/complicações , Doença da Artéria Coronariana/fisiopatologia , Complicações do Diabetes/complicações , Complicações do Diabetes/fisiopatologia , Stents Farmacológicos/tendências , Humanos
19.
Int J Cardiol ; 132(1): 121-2, 2009 Feb 06.
Artigo em Inglês | MEDLINE | ID: mdl-17692950

RESUMO

Stent strut fracture (SSF) after drug-eluting stent (DES) implantation may be an important complication after DES implantation particularly in patients undergoing sirolimus eluting stent implantation. Since SSF is a highly relevant adverse event which can result in in-stent restenosis and thrombosis, we believe that DES with flexible stent platform or biodegradable DES may be needed to prevent this potential catastrophic complication.


Assuntos
Reestenose Coronária/etiologia , Stents Farmacológicos/efeitos adversos , Trombose/etiologia , Reestenose Coronária/prevenção & controle , Stents Farmacológicos/classificação , Stents Farmacológicos/normas , Falha de Equipamento , Humanos , Imunossupressores/administração & dosagem , Incidência , Fatores de Risco , Sirolimo/administração & dosagem , Trombose/prevenção & controle , Falha de Tratamento
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