Prevalence of Psychiatric Disorders among Children and Adolescents: A Study from Khuzestan.

Objective: This cross-sectional study aimed to study the prevalence rate of psychiatric disorders in children and adolescents in Khuzestan province. Materials & Methods: A community sample consisting of 1028 (51.6% female) children and adolescents aged 6-18 years was selected using a multistage cluster sampling method. Data were gathered using the Kiddie-SADS-Present and Lifetime Version (K-SADS-PL) and a demographic questionnaire (i.e., gender, age, level of education, place of residence, parent's education, and parent's Job). Results: Nearly 22.6% (22.3% of boys and 23% of girls) of all participants suffered from at least one psychiatric disorder. There was no significant difference in the prevalence of psychiatric disorders based on gender, age, father's education, mother's education, mother's job, and father's job (all p>0.05). Psychiatric disorders were significantly more prevalent among children and adolescents in urban areas compared to rural places (2.9% vs. 8.1; p<0.001). The most prevalent category was anxiety disorders (15%). Also, the most common disorders were specific phobia (7%), separation anxiety disorder (6.3%), and enuresis (5.2%). The most common comorbid disorders were mood disorders and anxiety disorders (56.3%), followed by anxiety disorders and elimination disorders (32.1%). Discussion: Psychiatric conditions are prevalent in children and adolescents living in Khuzestanian. The study's findings have important implications for providing effective psychiatric services.

Assessing the Functions of Non-Suicidal Self-Injury: Factor Analysis of Functional Assessment of Self-Mutilation among Adolescents.

Objective: The aim of this cross sectional study was to assess the factor analysis of Functional Assessment of Self-Mutilation (FASM) among Iranian adolescents with non-suicidal self-injury. Method: In this study, 646 high school students, with the mean age of 16.55 ± 0.7, were selected using a multistage cluster sampling method; they completed FASM and the demographic form. Data were analyzed using the descriptive statistics, chi-square (χ2), independent sample t test, MANOVA, and confirmatory factor analyses (CFA). Results: Of the participants, 178 reported at least 1 episode of NSSI during the previous year. The mean age of the participants when they first harmed themselves was 14.64 (±1.71). Most of them reported to engage in NSSI impulsively (39.32%) and experienced little (31.5%) or moderate physical pain (31.5%) There were no significant differences between males and females in severity of NSSI, frequency of NSSI, thinking about NSSI prior to engaging in the act, and age of onset. The results of the confirmatory factor analysis supported the 4-factor model of NSSI functions suggested by Nock and Prinstine [Χ2/df = 1.84; RMSEA = 0.07; GFI = 0.82; AGFI = 0.77]. The most frequent function for engaging in NSSI was Automatic Negative Reinforcement. Conclusion: Findings of this study supported the structural validity of the FASM; thus, this tool can be useful in treatment and research contexts as a measure of NSSI functions. Moreover, this study found that adolescents engage in non-suicidal self-injury because of 4 distinct reinforcement processes. The study findings have important implications for the assessment and treatment of NSSI.

Toxoplasma gondii Exposure and the Risk of Attention Deficit Hyperactivity Disorder in Children and Adolescents.

BACKGROUND: Evidence suggests that Toxoplasma gondii, which causes toxoplasmosis, changes the metabolism of neurotransmitters, especially dopamine, resulting in both neurologic and psychiatric disorders. On the other hand, the dysregulation of catecholamines, especially of both norepinephrine and dopamine, has been proposed in the pathophysiology of attention deficit hyperactivity disorder (ADHD). The aim of the present study was to investigate anti-toxoplasma antibodies in children and adolescents with ADHD and compare it with a control group, to determine whether toxoplasmosis is a risk factor for ADHD. METHODS: A total of 200 children and adolescents (117 patients with ADHD and 83 individuals without ADHD) participated in the study. Participants were tested for the presence of anti-T. gondii antibodies by enzyme-linked immunosorbent assay. A Parent ADHD Rating Scale and Clinical Global Impression-severity Scale were also completed. Data were analyzed using a χ test and Fisher exact test. RESULTS: Anti-toxoplasma antibodies were detected in 18.1% of patients with ADHD disorder and 24% of individuals without ADHD. There was no significant difference in seropositivity between the 2 groups (P > 0.05). The number of patients with T. gondii infection in the 3 subgroups was 0, 9 and 12, respectively. The differences in infection rate among subgroups were not statistically significant (P > 0.05). CONCLUSION: Although not conclusive, the present study does not support the theory that T. gondii is a risk factor for ADHD.

Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals.

Background. The present study aimed to compare plasma levels of cortisol, testosterone, dehydroepiandrosterone (DHEA), and prolactin in patients with schizophrenia and healthy individuals. Method. A total of 100 patients with schizophrenia disorder (69 men and 31 women) and 190 healthy individuals (94 men and 96 women) participated in this cross-sectional study. They were tested for hormone levels and completed demographic questionnaires. Data were analyzed using multivariate analysis of variance (MANOVA) and one-way analysis of variance. Results. Serum testosterone level was significantly higher in men with schizophrenia than in healthy men. Women with schizophrenia had a significantly higher level of testosterone and lower level of prolactin compared to healthy women. There were no significant differences in hormone levels across various subtypes of schizophrenia. No significant differences also were observed in hormones levels in patients with first-episode schizophrenia disorder compared to those in patients with recurrent episodes. Conclusion. This study indicated that abnormal testosterone and prolactin levels might be associated with pathophysiology of schizophrenia disorder.

Effect of Group Cognitive-Behavioral Therapy on Health-Related Quality of Life in Females With Premenstrual Syndrome.

BACKGROUND: The premenstrual syndrome (PMS) is characterized by intense physical and psychological changes. The most common symptoms include anxiety, depression, fatigue, anger, irritability, sense of being out of control, confusion, change in appetite and sleep, bloating and breast tenderness. The symptoms affect the quality of life of women, and cause impairment in many aspects of life. OBJECTIVES: The purpose of this study was to examine the effects of cognitive-behavioral therapy (CBT) on improvement of health-related quality of life in female students with premenstrual syndrome (PMS). MATERIALS AND METHODS: In this study, 40 students with PMS were selected from Shahid Chamran university in Tehran, Iran, and were randomly assigned to the intervention and control groups. Participants in the intervention group received 10 sessions of CBT. Women in the control group did not receive any treatment. RESULTS: The results of ANCOVA were statistically significant (P < 0.001), and showed that group CBT improved the quality of life in the experimental group compared to the control group. In addition, the effects of the intervention on quality of life lasted for 2 months. CONCLUSIONS: Cognitive-behavioral therapy can be effective in improvement of health-related quality of life of female students with PMS.

Investigation of Mental Health in Patients with Medically Unexplained Physical Symptoms .

OBJECTIVE: Medically unexplained symptoms are physical symptoms, which cannot be explained by organic causes. This study aimed to investigate mental health in patients with medically unexplained physical symptoms. METHOD: One hundred outpatients who were admitted to the Electro Diagnosis Clinic of Imam Khomeini hospital, Ahvaz/Iran, participated in this study. Data were collected using physical examination, paraclinical examinations, and SCL-90-R, and analyzed through multivariate analysis of variance (MANOVA), Chi-square test and Fisher's exact test. RESULTS: The findings revealed significant differences between clients with medically explained and unexplained symptoms in obsessive compulsive and somatization (p<0.05). Differences in depression, anxiety, phobia, psychosis, aggression and paranoia were not significant (p>0.05). CONCLUSION: The present study suggested an association between some psychological problems and somatic symptoms. Therefore, screening for psychological impairments can improve clinical outcomes. .

Mental Health and Latent Toxoplasmosis: Comparison of Individuals with and without Anti-Toxoplasma Antibodies.

AIM: There is evidence to suggest that the protozoan Toxoplasma gondii affects the mental health of people who are infected with it. The aim of the present study was to examine the relationship between T. gondii and mental health. METHODS: A total of 200 students (87 men and 113 women) of Jundishapur University of Medical Sciences (Ahvaz, Iran) were tested for the presence of anti-Toxoplasma antibodies and completed the General Health Questionnaire (see Appendix 1, available at: http://www.longwoods.com/content/24938) and a demographic form. Data were analyzed using independent samples t-test, chi-square test and Fisher's exact test. RESULTS: Infected women had significantly lower scores in somatic symptoms (p = 0.04), anxiety/insomnia (p = 0.006) and depression (p = 0.04) compared with non-infected women. Difference in social dysfunction was not significant (p > 0.05). There were no significant differences in somatic symptoms, anxiety/insomnia, depression and social dysfunction between infected and non-infected men (all p > 0.05). CONCLUSION: Our findings indicate that latent toxoplasmosis can affect some components of mental health just in women.

Effect of Cognitive Behavior Group Therapy on Parenting Stress in Mothers of Children With Autism.

BACKGROUND: Due to the various problems of children with autism, their families and especially their mothers become exposed to stress. OBJECTIVES: This study aimed to evaluate the effect of cognitive behavior group therapy on parenting stress of mothers of children with autism. MATERIALS AND METHODS: The sample of this research consisted of sixteen mothers of children with autism. The measurement tools were the Abidin Parenting Stress questionnaire and a demographic questionnaire. The samples participated in seven sessions of cognitive behavior group therapy. The data were analyzed using the repeated measures test. RESULTS: The findings indicated significant differences between scores of pretest and posttest considering parenting stress (P = 0.03) and subscales of parenting distress (P = 0.01), yet there weren't significant differences in the other subscales (P > 0.05). CONCLUSIONS: Cognitive behavior group therapy could be an important part of interventions used to decrease parenting stress of mothers of children with autism.

Toxoplasma gondii Exposure and the Risk of Schizophrenia.

BACKGROUND: Schizophrenia is a major psychiatric disorder with a deeply destructive pathophysiology. There are evidences to indicate that infectious agents such as Toxoplasma gondii may play some roles in etiology of the disorder. OBJECTIVES: The current study aimed to determine the association between T. gondii exposure and the risk of schizophrenia. MATERIALS AND METHODS: T. gondii IgG antibodies of 100 patients with schizophrenia as well as 200 healthy volunteers were assessed. The subjects also completed demographic questionnaires. Data was analyzed using the chi-square and Fisher exact tests. RESULTS: The analyses confirmed the significant differences between healthy women and ones with schizophrenia (P = 0.001) as well as between males and females with schizophrenia (P = 0.009) in IgG positivity. CONCLUSIONS: The present study supported the contamination with T. gondii as a risk factor for schizophrenia just in women.